Asthma Experience in an Occupational and Environmental Medicine Clinic

Kipen, Howard M.; Blume, Richard; Hutt, Douglas A.

doi:10.1097/00043764-199410000-00017

Cited by 73 publications

(37 citation statements)

References 8 publications

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“…This disorder may occur when cleaning products are being mixed and exposure to chlorine or monochloramine gas results (10). A final mechanism is lowdose RADS, due to repeated exposures to moderate levels of irritants, with a not-so-sudden onset of asthma (24,25).…”

Section: Discussionmentioning

confidence: 99%

Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners

Kogevinas²,

Sunyer³

et al. 2001

Scand J Work Environ Health

103

114

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Section: Discussionmentioning

confidence: 99%

Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners

Kogevinas²,

Sunyer³

et al. 2001

Scand J Work Environ Health

103

114

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“…Several investigators have proposed to extend the spectrum of irritant-induced asthma to include new-onset asthma and reactivation of quiescent asthma in individuals who are repeatedly exposed to "moderate" or "excessive", although poorly documented, concentrations of irritant substances in the workplace [59,60]. Evidence supporting such concepts of "low-dose RADS" or "not-so-sudden RADS" is still very weak.…”

Section: Nonimmunological Occupational Asthma (Without a Latency Period)mentioning

confidence: 99%

Definitions and types of work-related asthma: a nosological approach

Vandenplas¹,

Jl²

2003

Eur Respir J

109

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The workplace can trigger or induce asthma and cause the onset of different types of work-related asthma. Analysis of previous definitions of occupational asthma (OA) led to the conclusion that evidence of a direct causal relationship between workplace exposure and the development of asthma remains the key element for defining OA.Based on clinical features and pathophysiological mechanisms, the following conditions should be distinguished in the spectrum of work-related asthma: 1) immunological OA characterised by a latency period necessary to acquire immunologically induced sensitisation; 2) nonimmunological OA characterised by the rapid onset of asthma following single or multiple exposures to high concentrations of irritant compounds; 3) work-related asthma defined by exacerbation of symptoms in workers with pre-existing or coincident asthma; and 4) variant syndromes including eosinophilic bronchitis, potroom asthma, and asthma-like disorders caused by organic dusts.The issues and controversies relating to this approach are critically reviewed in order to stimulate the consensus development of operational definitions of work-related asthma. Eur Respir J 2003; 21: 706-712.

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“…This can be described as a new onset of an -irritant-induced asthma within 24 hours after a single exposure to high concentrations of a respiratory irritant gas, fumes or vapour (Tarlo 2003). Subsequently a discussion has arisen about the existence of a low-level RADS (Kipen et al 1994;Tarlo 2000), as well as the idea of a "not so sudden" irritant-induced asthma (Banks 2001).…”

Section: Introductionmentioning

confidence: 99%

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Graff¹,

Fredrikson²,

Jonsson³

et al. 2011

Int Arch Occup Environ Health

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Non-sensitising air pollution at workplaces and adult onset asthma -2- AbstractPurpose This case-control study was undertaken to elucidate the controversy concerning whether low level, long-term exposure to non-sensitising air pollution at workplaces may cause asthma.Methods A case-control study of 192 adult onset asthma cases aged 20 -65 years and 323 controls was conducted in the southeast of Sweden. Cases were identified from computerised registers from the region, diagnosed 2000-2004 and diagnoses were confirmed via medical files. Referents were randomised from the population register of the region. Exposure was monitored by a 16-page questionnaire. Special attention was devoted to identifying and in the final analyses excluding subjects exposed to sensitising agents.Results Three years or more of occupational exposure to air pollution from dust, smoke, fumes or vapours before the year of diagnosis by analyses adjusting for age yielded an increased risk for asthma (OR =2.3, 95 % CI 1.2-4.2) in males, while in females no risk was seen. In a multiple logistic regression analysis in males without allergy in childhood, a significant risk was seen (OR=2.8, 95 % CI 1.07 -7.4), when subjects exposed to identified allergens were excluded. In females no excess risk was observed from occupational air pollution. ConclusionThe results of this study support an association between occupational exposure to low level non-sensitising air pollution and adult onset asthma in males.Non-sensitising air pollution at workplaces and adult onset asthma -3-

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Asthma Experience in an Occupational and Environmental Medicine Clinic

Cited by 73 publications

References 8 publications

Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners

Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners

Definitions and types of work-related asthma: a nosological approach

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

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