Asthma exacerbations: a paradigm of synergy between allergens, pollutants and viruses

Magnan, A.; Botturi, K.; Pipet, A.; Cavaillès, Arnaud; Reboulleau, Damien; Langelot, Marie; Lacoeuille, Y.; Berthoux, E.; Neveu, B.

doi:10.1533/9781908818065.89

Cited by 3 publications

(1 citation statement)

References 86 publications

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“…Clearance of allergens is also an important function of SP-A and SP-D as allergens may have a synergistic role with viruses in inducing exacerbations of inflammatory lung diseases including asthma ( 143 ). SP-A and SP-D are widely reported to bind to and enhance the uptake and clearance of allergens from A. fumigatus ( 144 ), house dust mite ( 145 ) and various types of pollen ( 146 , 147 ).…”

Section: Immunomodulatory Functions Of Sp-a and Sp-dmentioning

confidence: 99%

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

2021

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Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP-D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. Here, we review how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections. Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection while also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). Recombinant SP-A and SP-D could have therapeutic potential in neutralizing both current and future strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as well as modulating the inflammation-mediated pathology associated with COVID-19. A recombinant fragment of human (rfh)SP-D has recently been shown to neutralize SARS-CoV-2. Further work investigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated.

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Section: Immunomodulatory Functions Of Sp-a and Sp-dmentioning

confidence: 99%

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

2021

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Surfactant Proteins SP-A and SP-D and Conventional Risk Factors for Chronic Noncommunicable Human Diseases

Nikolaev,

Kharlamova,

Kosarev

et al. 2024

Cell Tiss. Biol.

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SP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseases

Nikolaev,

Kharlamova,

Kosarev

et al. 2023

Sibirskij nauchnyj medicinskij zhurnal

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Surfactant proteins SP-A and SP-D, which belong to the family of collagen-containing type C lectins, are used as diagnostic and prognostic markers for many acute and chronic respiratory diseases. The aim of the study is to assess the impact of conventional risk factors for chronic non-infectious diseases on SP-A and SP-D protein levels by means of systemic and structural analysis on the basis of relevant publications from international databases and official WHO reports. This analytical review concludes that widespread expression of SP-A and SP-D is documented in numerous studies, and, although the lungs remain the main site of synthesis of surfactant proteins, one can expect its significant impact on the immune and inflammatory response in many organs and tissues. The authors note that there are several known extrapulmonary effects of these proteins. However, many mechanisms of additional cellular effects of SP-A and SP-D outside the bronchopulmonary system still remain unstudied, which indicates the prospects for further research in this area.

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Asthma exacerbations: a paradigm of synergy between allergens, pollutants and viruses

Cited by 3 publications

References 86 publications

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

Surfactant Proteins SP-A and SP-D and Conventional Risk Factors for Chronic Noncommunicable Human Diseases

SP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseases

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