Asthma deaths in North Carolina: 1999–2016

Kearney, Gregory D.; Wooten, William; Mohan, Arjun; Carter, J. Christopher; Jones, Katherine A.; Blount, Theresa; O’Brien, Kevin F.

doi:10.1080/02770903.2019.1579830

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…According to health statistics, worldwide asthma mortality has significantly decreased over the past decades; nevertheless, the number of asthmatic patients who die still remains very high. [13][14][15][16][17] The decrease in asthma mortality may be attributed to the introduction of inhaled corticosteroids (ICSs) for treating asthma over the past 20-30 years. 18 The high number of deaths from asthma may be explained by a lack of recognition of fatal risk factors in asthmatic patients.…”

Section: Introductionmentioning

confidence: 99%

Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan

Chang

et al. 2020

npj Prim. Care Respir. Med.

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The independent risk factors for death in patients admitted for asthma exacerbation have not been thoroughly investigated. This study aimed to investigate these independent risk factors and the relationship between mortality and the prescription patterns of anti-asthmatic medications in patients admitted for asthma exacerbation. Using a nested case-control design, we identified 267 cases (death after asthma admission) and 1035 controls (survival after asthma admission) from the Taiwan National Health Insurance Research Database (NHIRD) from 2001 to 2010. Conditional logistic regressions were used to estimate the odds ratios (ORs) with 95% confidence intervals (CIs). We identified the independent risk factors for death as the comorbidities of pneumonia (aOR 3.82, 95% CI 2.41-6.05), genitourinary disease (aOR 1.75, 95% CI 1.17-2.62), septicemia (aOR 4.26, 95% CI 2.61-6.94), diabetes mellitus (aOR 2.10, 95% CI 1.30-3.38), arrhythmia (aOR 2.00, 95% CI 1.14-3.50), and a history of asthmatic hospitalization (aOR 4.48, 95% CI 2.77-7.25). Moreover, the use of short-acting β 2 -agonist (SABA) and the dosage of oral corticosteroids (OCSs) >70 mg prednisolone during previous hospitalization (all p < 0.05) and the dosage of OCSs ≥110 mg prednisolone/month (aOR 2.21, 95% CI 1.08-4.50) during outpatient treatment independently increased the risk of death. The inhaled corticosteroids (ICSs) ≥4 canisters/ year (aOR 0.39, 95% CI 0.19-0.78) independently reduced the risk of death. Specific comorbidities, asthma severity, and prescription patterns of SABA, OCSs, and ICSs were independently associated with mortality in patients admitted for asthma exacerbation. These results can be utilized to help physicians identify asthmatic patients who are at a higher mortality risk and to refine the management of the condition.npj Primary Care Respiratory Medicine (2020) 30:7 ; https://doi.

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Section: Introductionmentioning

confidence: 99%

Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan

Chang

et al. 2020

npj Prim. Care Respir. Med.

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“…Asthma mortality studies by zone report conflicting results whether populations of all ages, 9 children, adults or combinations of both. While one study showed increased asthma mortality with urbanization 10 others found higher mortality in rural zones 11,12 . Some of these studies, including an old Mexican study, 13 reported a favorable decreasing trend of asthma mortality overtime.…”

Section: Introductionmentioning

confidence: 99%

“…While one study showed increased asthma mortality with urbanization 10 others found higher mortality in rural zones. 11,12 Some of these studies, including an old Mexican study, 13 reported a favorable decreasing trend of asthma mortality overtime. Contrary to this, a recent US study found no significant changes from 1999 to 2015 and low mortality rate in children aged 1 to 14.…”

Section: Introductionmentioning

confidence: 99%

Asthma mortality among Mexican children: Rural and urban comparison and trends, 1999‐2016

Hernández‐Garduño

2020

Pediatric Pulmonology

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Objective Although there are more studies showing higher asthma prevalence in urban rather than rural zones, few assessed asthma mortality by zone in children. The objective of this study is to compare asthma mortality rates (AMR) by zone of residence of Mexican children. Design Using national death certificate and population projections data, AMR were compared in children aged 0 to 14 years by gender, age group, and zone of residence from 1999 to 2016. AMR trends were calculated using Joinpoint regression. Results Of the 680 823 deaths, 2464 (0.36%) were due to asthma. Asthma mortality was higher in rural (0.65%) than urban (0.26%) zones, P < .0001. Whole period AMR median was also higher in rural vs urban zones (0.6 vs 0.3, respectively), P < .05. The average annual percent change (AAPC) of AMR for the whole period was −5.1 in all children with a higher percent decrease in rural vs urban zones (girls' AAPC = −6.3 vs −4.1, respectively and boys' AAPC = −4.8 vs −4.2, respectively). AMR decreased in children aged 0 to 4 from both zones (rural's AAPC: girls = −7.9, boys = −5.2; urban's AAPC: girls = −5.1, boys = −5.4), P < .05. No trend was found in children aged 5 to 14. Conclusions Asthma mortality in Mexican children is higher in rural than urban zones. The decrease of mortality over time in early childhood is reassuring. More research is needed to determine reasons for higher mortality in rural Mexico and for the lack of a favorable decreasing trend in children aged 5 to 14 from both zones.

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Rural Health Disparities in Allergy, Asthma, and Immunologic Diseases: The Current State and Future Direction for Clinical Care and Research

Pongdee,

Brunner,

Kanuga

et al. 2024

The Journal of Allergy and Clinical Immunology: In Practice

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Asthma deaths in North Carolina: 1999–2016

Cited by 4 publications

References 36 publications

Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan

Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan

Asthma mortality among Mexican children: Rural and urban comparison and trends, 1999‐2016

Rural Health Disparities in Allergy, Asthma, and Immunologic Diseases: The Current State and Future Direction for Clinical Care and Research

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