Asthma control, quality of life and successful sputum induction

Majewski, Sebastian; Cichocki, Piotr; Stepnicka-Bindemann, M.; Górski, Paweł

doi:10.5114/aoms.2011.25559

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…It may suggest that this subscale covers a broader sense of burden of treatment and disease itself, but also the necessity of improving the medical information on advantages of shorter protocols. A similar relationship between HRQoL, symptoms of disease and specificity of treatment was also observed in asthmatic patients [23]. …”

Section: Discussionsupporting

confidence: 63%

Health-related quality of life in Polish adolescents with Hymenoptera venom allergy treated with venom immunotherapy

Cichocka‐Jarosz¹,

Brzyski²,

Świebocka³

et al. 2012

aoms

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IntroductionVenom allergy, though rare, may seriously influence health-related quality of life (HRQoL). There is a paucity of research on HRQoL of adolescents and young adults with Hymenoptera venom allergy. The aim was to assess the level of HRQoL and to evaluate its independent predictors in Polish adolescents and young adults treated with venom immunotherapy.Material and methodsA multicenter cross-sectional study based on the Vespid Allergy Quality of Life Questionnaire (VQLQ) adapted for Polish adolescents was used. The study sample included 87 patients (14-21 years) studied at different stages of venom immunotherapy (VIT). Statistical analysis was done with multivariate linear regression.ResultsAnxiety level was higher in patients with 4th grade of Mueller's classification (anaphylactic shock) than in those with 3rd grade (B = 0.84, 95% CI = 0.07-1.61, p = 0.03). Caution increased along with an increase of anxiety of adolescents treated with VIT (B = 0.54, 95% CI = 0.39-0.68, p < 0.01). Level of limitations increased with increasing caution of adolescents (B = 0.63, 95% CI = 0.35-0.91, p < 0.01). Discomfort increased along with a rise of caution of patients (B = 0.38, 95% CI = 0.22-0.55, p < 0.01). Similarly, it increased with an increase of their feeling of limitations (B = 0.37, 95% CI = 0.23-0.51, p < 0.01). The level of discomfort in adolescents treated with VIT was lower in those who were treated with conventional protocol in comparison to those treated with rush or ultra-rush ones (B = –0.47, 95% CI = –0.90 - –0.03, p = 0.04).ConclusionsSeverity of anaphylactic reaction is an independent determinant of anxiety level in adolescents treated with VIT. The VIT protocol affects HRQoL of treated patients.

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Section: Discussionsupporting

confidence: 63%

Health-related quality of life in Polish adolescents with Hymenoptera venom allergy treated with venom immunotherapy

Cichocka‐Jarosz¹,

Brzyski²,

Świebocka³

et al. 2012

aoms

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“…Nonasthmatic eosinophilic bronchitis diagnosis requires successful sputum induction, but this may be difficult to obtain as many patients are unable to produce adequate sputum samples [35]. In our study, NAEB was diagnosed in 13% of subjects.…”

Section: Discussionmentioning

confidence: 70%

“…According to guidelines on cough management, NAEB is responsible for chronic cough in about 10–20% of adult patients [ 12 ]. Nonasthmatic eosinophilic bronchitis diagnosis requires successful sputum induction, but this may be difficult to obtain as many patients are unable to produce adequate sputum samples [ 35 ]. In our study, NAEB was diagnosed in 13% of subjects.…”

Section: Discussionmentioning

confidence: 99%

Chronic cough – assessment of treatment efficacy based on two questionnaires

Dąbrowska¹,

Grabczak²,

Arcimowicz³

et al. 2014

aoms

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IntroductionEfficacy of chronic cough treatment is ambiguous. The aim of the study was to analyze chronic cough alleviation after specific treatment and the relationship between cough etiology and treatment efficacy.Material and methodsA stepwise diagnostic approach was used to diagnose cough etiology in non-smoking adults with chronic cough. In all patients specific treatment was applied. Two different questionnaires – a visual analog scale and a 5-degree scale – were used to assess cough severity before and after 4-6 months of treatment.ResultsA significant correlation between pre-treatment and post-treatment results of both questionnaires was found (Spearman coefficient 0.43, p = 0.0003 and 0.73, p < 0.0001, respectively). Baseline questionnaire analysis revealed no differences in cough severity between patients with different cough causes or multiple cough causes. Although specific treatment resulted in a significant decrease of cough severity in the entire group, only partial improvement was noted. According to the visual analogue scale, a decrease of cough severity by at least 50% was achieved only in 54.4% of patients (37/68). Similarly, satisfactory improvement was noted in only 54.4% (37/68) of patients when using the 5-point scale. There were three sub-groups of patients, in whom no relevant decrease of cough severity was observed despite treatment: patients with 1. three coexisting cough causes, 2. non-asthmatic eosinophilic bronchitis, and 3. chronic idiopathic cough.ConclusionsCough severity does not depend on its etiology. Efficacy of chronic cough treatment in non-smoking patients is only moderate.

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“…Sputum induction procedure was performed by a trained technician using the method described previously 49,53,54. Briefly, after salbutamol premedication (400 µg), aerosols of hypertonic saline of 3%, 4%, and 5% were each inhaled for 7 mins via ultrasonic nebulizer (Ultraneb 3000, Devilbiss, Somerset, PA, USA) with an output flow of 1 mL/min.…”

Section: Methodsmentioning

confidence: 99%

<p>Overexpression of chitotriosidase and YKL-40 in peripheral blood and sputum of healthy smokers and patients with chronic obstructive pulmonary disease</p>

Majewski

Tworek

Szewczyk

et al. 2019

COPD

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Background Despite the absence of endogenous chitin in humans, chitinases are present in the serum of healthy subjects and their levels are increased in a variety of chronic inflammatory conditions. It has been shown that chitotriosidase and structurally related chitinase-like protein-YKL-40 contribute to the pathogenesis of COPD. However, details regarding the relation of their systemic and local airways levels remain unknown. Objectives To examine peripheral blood and sputum chitotriosidase and YKL-40 expression in smokers and patients with COPD. Methods Forty patients with COPD, 20 healthy smokers and 10 healthy never-smokers were studied. Serum and induced sputum chitotriosidase protein and activity levels, YKL-40 concentrations, and their gene expression in sputum cells and peripheral blood mononuclear cells (PBMC) were evaluated. Results Both chitotriosidase protein levels and activity were higher in sputum obtained from COPD subjects compared to healthy never-smokers ( P <0.05 and P <0.01, respectively). A similar pattern was observed for PBMC chitotriosidase mRNA expression ( P <0.001). YKL-40 serum concentrations were elevated in healthy smokers and COPD subjects compared to healthy never-smokers ( P <0.001 and P <0.01, respectively). In sputum, YKL-40 levels were increased in COPD compared to healthy never-smokers ( P <0.01). PBMC YKL-40 mRNA expression was increased in COPD and healthy smokers compared to healthy never-smokers ( P <0.0001). No associations were found between chitotriosidase or YKL-40 peripheral blood levels and sputum levels. Conclusions Our results demonstrate that chitotriosidase and YKL-40 are overexpressed in peripheral blood and airways in both healthy smokers and COPD subjects which may indicate smoking-related activation of macrophages, neutrophils, and epithelial cells.

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Asthma control, quality of life and successful sputum induction

Cited by 5 publications

References 10 publications

Health-related quality of life in Polish adolescents with Hymenoptera venom allergy treated with venom immunotherapy

Health-related quality of life in Polish adolescents with Hymenoptera venom allergy treated with venom immunotherapy

Chronic cough – assessment of treatment efficacy based on two questionnaires

<p>Overexpression of chitotriosidase and YKL-40 in peripheral blood and sputum of healthy smokers and patients with chronic obstructive pulmonary disease</p>

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