Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis Among Women: A Prospective Cohort Study

Ford, Julia A.; Liu, Xinyi; Chu, Su H.; Lü, Bing; Cho, Michael H.; Silverman, Edwin K.; Costenbader, Karen H.; Camargo, Carlos A.; Sparks, Jeffrey A.

doi:10.1002/art.41194

Cited by 46 publications

(40 citation statements)

References 58 publications

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“…A third finding from this analysis that we initially found surprising was that most types of respiratory diseases were associated with an elevated risk of RA in nonsmokers, but not in smokers, and that there was no positive interaction between the 2 types of exposures. Other studies have found a similar pattern for asthma (15) and air pollution (39), supporting the validity of this result. These are notable findings, as smoking is associated with an increased risk of RA (40), and smoking also confers an increased risk of respiratory diseases as shown in a previous publication (41) and as replicated for individuals without RA in the present study.…”

Section: Discussionsupporting

confidence: 87%

“…One recent study demonstrated an association between respiratory diseases and ACPA/RF–positive RA (16), though that study did not specifically investigate whether respiratory disease preceded RA or not, and did not take smoking status into account. Another recently published study from the Nurses’ Health Study found an association of asthma and COPD with seronegative RA in women (15), but did not specifically address whether smoking and respiratory disease may confer risk for RA through similar or different mechanisms. Minimal data exist for other types of airway diseases.…”

Section: Introductionmentioning

confidence: 99%

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Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking

Kronzer

Westerlind

Alfredsson

et al. 2020

Arthritis & Rheumatology

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Objective. The link and interplay between different airway exposures and rheumatoid arthritis (RA) risk are unclear. This study was undertaken to determine whether respiratory disease is associated with development of RA, and specifically to examine this relationship by RA serostatus and smoking exposure. Methods. Using data from the Epidemiological Investigation of Rheumatoid Arthritis study, this analysis included 1,631 incident RA cases and 3,283 matched controls recruited from 2006 to 2016. Linking these individuals to the National Patient Register provided information on past diagnoses of acute or chronic upper or lower respiratory disease. For each disease group, we estimated adjusted odds ratios (OR adj) with 95% confidence intervals (95% CIs) for RA, using logistic regression models adjusted for age, sex, residential area, body mass index, and education level both overall and stratified by anti-citrullinated protein antibody (ACPA)/rheumatoid factor (RF) status and by smoking status. Results. Respiratory disease diagnoses were associated with risk of RA, with an OR adj of 1.2 (95% CI 0.8-1.7) for acute upper respiratory disease, 1.4 (95% CI 1.1-1.9) for chronic upper respiratory disease, 2.4 (95% CI 1.5-3.6) for acute lower respiratory disease, and 1.6 (95% CI 1.5-3.6) for chronic lower respiratory disease. These associations were present irrespective of RF or ACPA status, though the association was somewhat stronger for ACPA-positive or RF-positive RA than for ACPA-negative or RF-negative RA. The association between any respiratory disease and RA was stronger for nonsmokers (OR adj 2.1 [95% CI 1.5-2.9]) than for smokers (OR adj 1.2 [95% CI 0.9-1.5]). Conclusion. Respiratory diseases increase the risk for both seropositive and seronegative RA, but only among nonsmokers. These findings raise the hypothesis that smoking and airway disease are associated with RA development through partly different mechanisms.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking

Kronzer

Westerlind

Alfredsson

et al. 2020

Arthritis & Rheumatology

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“…Large-scale, prospective observational cohorts have become essential resources for investigation into the causes of many diseases, especially common multifactorial diseases with multiple environmental and genetic determinants (1)(2)(3)(4). When they are based on samples representative of the general population, prospective cohorts may also be used for descriptive and epidemiological surveillance purposes.…”

Section: Introductionmentioning

confidence: 99%

“…Inserm UMS 011, Population-based Epidemiological Cohorts, Villejuif, France, 2 Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP, Villejuif, France,3 ClinSearch, Malakoff, France,4 Luxembourg Institute of Health, Luxembourg, Luxembourg,5 Integrated Biobank of Luxembourg (IBBL), Dudelange, Luxembourg,6 Faculty of Medicine, University of Paris, Paris, France…”

mentioning

confidence: 99%

The CONSTANCES Cohort Biobank: An Open Tool for Research in Epidemiology and Prevention of Diseases

Henny

Nadif

Got

et al. 2020

Front. Public Health

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“General-purpose cohorts” in epidemiology and public health are designed to cover a broad scope of determinants and outcomes, in order to answer several research questions, including those not defined at study inception. In this context, the general objective of the CONSTANCES project is to set up a large population-based cohort that will contribute to the development of epidemiological research by hosting ancillary projects on a wide range of scientific domains, and to provide public health information. CONSTANCES was designed as a randomly selected sample of French adults aged 18–69 years at study inception; 202,045 subjects were included over an 8-year period. At inclusion, the selected participants are invited to attend one of the 24 participating Health Prevention Centers (HPCs) for a comprehensive health examination. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HPC. Procedures have been developed to use the national healthcare databases to allow identification and validation of diseases over the follow-up. The biological collection (serum, lithium heparinized plasma, EDTA plasma, urine and buffy coat) began gradually in June 2018. At the end of the inclusions, specimens from 83,000 donors will have been collected. Specimens are collected according to a standardized protocol, identical in all recruitment centers. All operations relating to bio-banking have been entrusted by Inserm to the Integrated Biobank of Luxembourg (IBBL). A quality management system has been put in place. Particular attention has been paid to the traceability of all operations. The nature of the biological samples stored has been deliberately limited due to the economic and organizational constraints of the inclusion centers. Some research works may require specific collection conditions, and can be developed on request for a limited number of subjects and in specially trained centers. The biological specimens that are collected will allow for a large spectrum of biomarkers studies and genetic and epigenetic markers through candidate or agnostic approaches. By linking the extensive data on personal, lifestyle, environmental, occupational and social factors with the biomarker data, the CONSTANCES cohort offers the opportunity to study the interplays between these factors using an integrative approach and state-of-the-art methods.

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“…Development of COPD in RA patients 29is consistent with the known pulmonary involvement in RA (25,30). Conversely, a recent study identified COPD as a risk factor for RA with the strongest association between COPD and seropositive RA in older smokers (31). Interestingly, individuals who were ACPA positive before RA diagnosis were at increased risk of developing COPD (32).…”

Section: Cigarette Smokementioning

confidence: 63%

Perspective: The Lung, Particles, Fibers, Nanomaterials, and Autoimmunity

Pollard

2020

Front. Immunol.

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Studies have shown that a wide range of factors including drugs, chemicals, microbes, and other environmental agents can induce pre-clinical autoimmunity. However, only a few have been confidently linked to autoimmune diseases. Among these are exposures to inhaled particulates that are known to be associated with autoimmune diseases such as lupus and rheumatoid arthritis. In this article, the potential of particle, fiber, and nanomaterial exposures to induce autoimmunity is discussed. It is hypothesized that inhalation of particulate material known to be associated with human autoimmune diseases, such as cigarette smoke and crystalline silica, results in a complex interplay of a number of pathological processes, including, toxicity, oxidative stress, cell and tissue damage, chronic inflammation, post-translational modification of self-antigens, and the formation of lymphoid follicles that provide a milieu for the accumulation of autoreactive B and T cells necessary for the development and persistence of autoimmune responses, leading to disease. Although experimental studies show nanomaterials are capable of inducing several of the above features, there is no evidence that this matures to autoimmune disease. The procession of events hypothesized here provides a foundation from which to pursue experimental studies to determine the potential of other environmental exposures to induce autoimmunity and autoimmune disease.

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Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis Among Women: A Prospective Cohort Study

Cited by 46 publications

References 58 publications

Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking

Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking

The CONSTANCES Cohort Biobank: An Open Tool for Research in Epidemiology and Prevention of Diseases

Perspective: The Lung, Particles, Fibers, Nanomaterials, and Autoimmunity

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