Asthma as a disruption in iron homeostasis

Ghio, Andrew J.

doi:10.1007/s10534-016-9948-y

Cited by 11 publications

(10 citation statements)

References 356 publications

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“…Asthma and COPD belong to the subgroup of obstructive pulmonary diseases [158]. The potential role of a disrupted iron homeostasis in asthma was reviewed in great detail recently [159]. Briefly, the author reported profound evidence of disturbed iron homeostasis in asthma by systematically evaluating the known demographic (e.g., ethnicity), physiologic (e.g., exercise), and pathologic (e.g., infections) asthma determinants in the context of iron availability and concluded a setting of absolute or functional iron deficiency in asthma, which may have therapeutic implications in the future.…”

Section: Linking Lung-related Diseases To Disrupted Lung Iron Homementioning

confidence: 99%

Iron Homeostasis in the Lungs—A Balance between Health and Disease

et al. 2019

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A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function. Imbalances in pulmonary iron homeostasis are frequently associated with respiratory diseases, such as chronic obstructive pulmonary disease and with lung cancer. However, the underlying mechanisms causing alterations in iron levels and the involvement of iron in the development of lung disorders are incompletely understood. Here, we review current knowledge about the regulation of pulmonary iron homeostasis, its functional importance, and the link between dysregulated iron levels and lung diseases. Gaining greater knowledge on how iron contributes to the pathogenesis of these diseases holds promise for future iron-related therapeutic strategies.

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Section: Linking Lung-related Diseases To Disrupted Lung Iron Homementioning

confidence: 99%

Iron Homeostasis in the Lungs—A Balance between Health and Disease

et al. 2019

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“…Preservation of iron homeostasis is of extreme importance for the respiratory physiology and pathophysiology as well as local iron deficit or accumulation may result in certain respiratory function impairment Forced Expiratory Volume in one second (FEV1,) Forced Vital Capacity (FVC), FEV1/FCV and Peak Expiratory Flow (PEF). [12,[13][14][15][16][17].It had been shown that iron-supplemented diet had markedly decreased allergen-induced airway hyperreactivity, by decreasing mast cell activation [3,4,[17][18][19]. Identification of further treatments that could preclude or decline the rigorousness of asthma would offer a chief progress in clinical attention of patients with allergen-started asthma [20,21].…”

Section: Issue 2decsmber 2019mentioning

confidence: 99%

Iron Deficit Anemia As a Risk Factor of Asthma

Alkhateeb¹,

Khalil²,

Kadhim³

et al. 2019

DJM

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Background: There are many risk factor for asthma occurrence like gender, atopy and infection. Trace elements like iron, magnesium and zinc play a role in decreasing airway hyperreponsiveness. Objective: To evaluate iron deficiency anemia as a risk factor for childhood asthma and its likely outcome on lung functions. Patients and Methods: Across-sectional comparative study was conducted on 200 children, 6-14 years old who admitted to the outpatient pediatric clinics and emergency department of Albatool Teaching hospital in Diyala governorate from Oct. 2017 to Oct 2018, they were categorized into: group I: 100 children with IDA-who was subdivided into group Ia: Asthmatic children and group I b: Non asthmatic children. Group II: 100 children without IDA, subdivided into group II a: asthmatic children and group II b: non-asthmatic children. Results: Children with asthma in group I a the male to female ratio was 1.75/1.0 and in group II b the ratio was 1.4/1.0.The anemic group with asthma constitute 66% of group I, while in group II the asthmatic children constituted 24%of included children. Anemic asthmatic children had significant difference regarding pulmonary function tests in comparison to non-anemic asthmatics. Conclusion: Anemic asthmatics group constituted 66%, and anemia had significant detrimental effects on pulmonary function tests in comparison to non-anemic asthmatics.

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“…More than 80% of the patients with asthma had concomitant rhinitis, and 10–40% of the patients with rhinitis had concomitant asthma,22 which lends credence to the concept of “one airway, one disease” 3. It has also been shown that urticaria is a common co-morbidity of asthma,23 and also has significant correlation with AR and asthma 24. However, the increased risk of CU in different age groups was not consistent.…”

Section: Discussionmentioning

confidence: 99%

<p>Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China</p>

Chen¹,

Sng²,

Wang³

et al. 2019

TCRM

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Background Several studies have shown that the use of antibiotics early in life significantly increases the risk of asthma in children. It is unclear whether antibiotics are more commonly used in patients with allergy-related diseases. Methods A multistage, clustered and random sampling with a field-interviewer-administrated survey study was performed to investigate if there was multiple use of antibiotics (MUA) in patients with allergic rhinitis (AR), conjunctivitis, chronic urticaria (CU), and asthma in the grasslands of northern China. MUA was defined as antibiotic usage for at least 3 days and for more than 3 times a year in the past 2 years. Results A total of 5,787 subjects completed the study, with 1,079 subjects (18.6%) identified as MUA. MUA was more common in patients with AR (23.7% vs 16.2%, P <0.001), conjunctivitis (22.5% vs 17.1%, P <0.001), asthma (31.8% vs 17.7%, P <0.001), and CU (25.9% vs 18.3%, P <0.01) than in subjects without allergic diseases. There is an increasing percentage of MUA in patients with a single, two, and three or more diseases both in children (20.1%, 25.0%, and 31.4%, respectively, P =0.014) and in adults (19.1%, 23.4%, and 32.9%, respectively, P <0.001). MUA is significantly associated with AR (OR=1.7, 95% CI: 1.3–2.1, P <0.001), conjunctivitis (OR=1.6, 95% CI: 1.2–2.1, P =0.001), asthma (OR=2.3, 95% CI:1.6–3.3, P <0.001) and CU (OR=2.1, 95% CI: 1.2–3.6, P =0.006) in children aged 2–17 years; and in adults (≥18 years old) for AR (OR=1.7, 95% CI: 1.4–2.1, P <0.001), conjunctivitis (OR=1.3, 95% CI:1.1–1.6, P =0.002), and asthma (OR=2.0, 95% CI: 1.5–2.7, P <0.001). Conclusion Antibiotic overuse might be associated with increased risk of allergy-related disease. It is important that implementation of the evidence-based international guidelines for the management of allergy-related diseases needs to be improved, in order to avoid unnecessary use of antibiotics.

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Asthma as a disruption in iron homeostasis

Cited by 11 publications

References 356 publications

Iron Homeostasis in the Lungs—A Balance between Health and Disease

Iron Homeostasis in the Lungs—A Balance between Health and Disease

Iron Deficit Anemia As a Risk Factor of Asthma

<p>Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China</p>

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