Asthma and subjective sleep disordered breathing in a large cohort of urban adolescents

Abstract

Objective Sleep disordered breathing (SDB) has not been well studied in urban adolescents with asthma in community settings. Nor has the association of SDB symptoms and asthma severity been studied. We characterized self-reported symptoms suggesting SDB and investigated the association of SDB symptoms, probable asthma, and asthma severity. Methods 9,565 adolescents from 21 inner-city high schools were screened for an asthma intervention study. Students reported on symptoms suggesting SDB using questions from the 2007 NHANES, if they were ever diagnosed with asthma, and on asthma symptoms. Using generalized linear mixed models with logit link with school as a random intercept and adjusting for age, gender, and race/ethnicity, we examined associations of SDB symptoms, and demographic characteristics, probable asthma, and asthma severity. Results 12% reported SDB symptoms. Older and biracial participants (compared to Caucasian) had higher odds of symptoms suggesting SDB (p<.001). Compared to those without probable asthma, adolescents with probable asthma had 2.63 greater odds of reporting SDB symptoms (p<.001). Among those with probable asthma, the odds of reporting SDB symptoms increased with asthma severity. When exploring daytime severity and severity due to night wakening separately, results were similar. All results remained significant when controlling for age, gender, and ethnicity. Conclusions In a large urban community cohort of predominately ethnic minority adolescents, self-reported SDB symptoms were associated with probable asthma and increased asthma severity. This study highlights the importance of SDB as a modifiable co-morbidity of asthma.

Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China

“…However, children aged 12-14 years old always sleep alone and parents cannot observe their sleep conditions very well which may affect SDB prevalence. Among other demographic correlates, we did not identify an association between SDB symptoms and gender, correlating with the findings of a previous study [2]. An association between SDB symptoms and BMI was also not identified in this study.…”

“…Sleep quality is critical for the growth and development of children [1]. Sleep-disordered breathing (SDB) is a syndrome common in childhood, the spectrum of which ranges from primary snoring to partial or complete airway obstruction, termed obstructive sleep apnea syndrome (OSAS) [2]. It is important to determine the prevalence of SDB in children because of its association with the functioning of various organs, including immune responses, cardiovascular function, and neurocognitive function [2].…”

Relationship between Poorly Controlled Asthma and Sleep-Related Breathing Disorders in Children with Asthma: A Two-Center Study

“…SRBD are common in childhood; its spectrum ranges from primary snoring to partial or complete airway obstruction, which is termed obstructive sleep apnea syndrome (OSAS) [ 6 ]. SRBD affects 5.1–13.3% of children [ 7 – 16 ], resulting in dysfunction of immune responses, cardiovascular function, and neurocognitive function [ 6 ]. Recently, research has shown that asthma is associated with a high risk of SRBD in children.…”

“…Another meta-analysis of 12 studies that included 38,766 subjects showed that SRBD is correlated with the prevalence of asthma in children (OR, 1.58; 95% CI, 1.35–1.80) [ 14 ]. Zandieh et al enrolled 9,565 adolescents in their study and found that adolescents with asthma have 2.63 times higher odds of developing SRBD than those without asthma [ 6 ].…”

Prevalence of asthma and sleep-related breathing disorder in school-going children

“…studied asthma and SRBD in 9565 adolescents and found that adolescents with probable asthma had 2.63 higher odds of reporting SRBD symptoms. [ 20 ] There is a lack of data in India on population-based studies in asthma and SRBD.…”