Asthma and Respiratory Infections From Birth to Young Adulthood

Belachew, Abate Bekele; Rantala, Aino K.; Jaakkola, Maritta S.; Hugg, Timo T.; Jaakkola, Jouni J. K.

doi:10.1093/aje/kwac210

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…The susceptibility of subjects having asthma to catch respiratory infections has been shown in our recently reported study based on the Espoo Cohort Study from Finland, which reported that children and young adults having asthma experience increased risk of both URTIs with an adjusted incidence rate ratio (aIRR) 1.27 (95% CI 1.20 -1.35) and LRTIs with aIRR 2.87 (95% CI 2.33-3.53) up to the age of 27 years [5]. Although the mechanisms for such susceptibility are not yet fully understood, both immunological dysfunction and structural airway alterations observed in subjects having asthma are likely to play a role.…”

Section: Discussionmentioning

confidence: 84%

“…However, this could have biased the results towards more severe respiratory infections, so we did not conduct this analysis. Those with asthma have been suggested to be more susceptible to experience respiratory infections in general [4,5]. As this study was limited to those with recently diagnosed adult-onset asthma, comparison between different occupational groups can be considered valid, as although subjects in occupations related to increased rate of respiratory infections may later change their job due to this asthma-related susceptibility to infections, in the present study the majority of participants were still going through or had just gone through the diagnostic measurements for asthma when answering the FEAS questionnaire and the others had just recently received this diagnosis.…”

Section: Validity Of the Resultsmentioning

confidence: 99%

“…The objective of the present study was to compare the occurrence of respiratory infections among different occupations in working-age adults with newly diagnosed asthma. Those with asthma are likely to form a group especially susceptible to respiratory infections [4,5]. Professionals, clerks, and administrative personnel formed the reference category in this study.…”

Section: Introductionmentioning

confidence: 99%

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Occupation and occurrence of respiratory infections among adults with newly diagnosed asthma

et al. 2023

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Background Work environments are potential areas for spreading respiratory infections. We hypothesized that certain occupations increase susceptibility to respiratory infections among adults with asthma. Our objective was to compare the occurrence of respiratory infections among different occupations in adults with newly diagnosed asthma. Methods We analysed a study population of 492 working-age adults with newly diagnosed asthma who were living in the geographically defined Pirkanmaa Area in Southern Finland during a population-based Finnish Environment and Asthma Study (FEAS). The determinant of interest was occupation at the time of diagnosis of asthma. We assessed potential relations between occupation and occurrence of both upper and lower respiratory tract infections during the past 12 months. The measures of effect were incidence rate ratio (IRR) and risk ratio (RR) adjusted for age, gender, and smoking habits. Professionals, clerks, and administrative personnel formed the reference group. Results The mean number of common colds in the study population was 1.85 (95% CI 1.70, 2.00) infections in the last 12 months. The following occupational groups showed increased risk of common colds: forestry and related workers (aIRR 2.20, 95% CI 1.15–4.23) and construction and mining (aIRR 1.67, 95% CI 1.14–2.44). The risk of lower respiratory tract infections was increased in the following groups: glass, ceramic, and mineral workers (aRR 3.82, 95% CI 2.54–5.74), fur and leather workers (aRR 2.06, 95% CI 1.01–4.20) and metal workers (aRR 1.80, 95% CI 1.04–3.10). Conclusions We provide evidence that the occurrence of respiratory infections is related to certain occupations.

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Section: Discussionmentioning

confidence: 84%

Section: Validity Of the Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occupation and occurrence of respiratory infections among adults with newly diagnosed asthma

et al. 2023

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“…In addition to maternal morbidities and in utero exposures, early-life exposures to respiratory viruses and bacteria, as well as environmental allergens, pollutants, and cigarette smoke have all shown an association with subsequent recurrent wheezing and asthma development (28)(29)(30)(31). In particular, the airway microbiome appears to play an important role in the development and phenotypic manifestations of asthma and allergy (32).…”

Section: Introductionmentioning

confidence: 99%

Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol

Kicic-Starcevich,

Hancock,

Iosifidis

et al. 2024

Front. Allergy

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IntroductionRecurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life.MethodsThe Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) study is nested within the ORIGINS Project and will monitor 400 infants from birth to 5 years. The primary outcome of the AERIAL study will be the identification of epithelial endotypes and exposure variables that influence the development of recurrent wheezing, asthma, and allergic sensitisation. Nasal respiratory epithelium at birth to 6 weeks, 1, 3, and 5 years will be analysed by bulk RNA-seq and DNA methylation sequencing. Maternal morbidities and in utero exposures will be identified on maternal history and their effects measured through transcriptomic and epigenetic analyses of the amnion and newborn epithelium. Exposures within the first year of life will be identified based on infant medical history as well as on background and symptomatic nasal sampling for viral PCR and microbiome analysis. Daily temperatures and symptoms recorded in a study-specific Smartphone App will be used to identify symptomatic respiratory illnesses.DiscussionThe AERIAL study will provide a comprehensive longitudinal assessment of factors influencing the association between epithelial dysfunction and respiratory morbidity in early life, and hopefully identify novel targets for diagnosis and early intervention.

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“…The amnion is also a source of epithelial cells that have been exposed to similar factors as the developing respiratory epithelium of the foetus/newborn [25][26][27]. In addition to maternal morbidities and in utero exposures, early-life exposures to respiratory viruses and bacteria, as well as environmental allergens, pollutants, and cigarette smoke have all shown an association with subsequent recurrent wheezing and asthma development [28][29][30][31]. One mechanism through which exposures appear to modulate future respiratory outcomes is through epigenetic reprogramming of host cells, with distinct methylation profiles being observed in respiratory epithelial cells from healthy, atopic, and asthmatic children [32].…”

Section: Introductionmentioning

confidence: 99%

Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol

Kicic-Starcevich

Hancock

Iosifidis

et al. 2023

Preprint

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Introduction: Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life. Methods and Analysis: The Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) study is nested within the ORIGINS Project and will monitor 400 infants from birth to five years. The primary outcome of the AERIAL study will be the identification of epithelial endotypes and exposure variables that influence the development of recurrent wheezing, asthma, and allergic sensitisation. Nasal respiratory epithelium at birth to six weeks, one, three, and five years will be analysed by bulk RNA-seq and DNA methylation sequencing. Maternal morbidities and in utero exposures will be identified on maternal history and their effects measured through transcriptomic and epigenetic analyses of the amnion and newborn epithelium. Exposures within the first year of life will be identified based on infant medical history as well as on background and symptomatic nasal sampling for viral PCR and microbiome analysis. Daily temperatures and symptoms recorded in a study-specific Smartphone App will be used to identify symptomatic respiratory illnesses. Ethics and Dissemination: Ethical approval has been obtained from Ramsey Health Care HREC WA-SA (#1908). Results will be disseminated through open-access peer-reviewed manuscripts, conference presentations, and through different media channels to consumers, ORIGINS families, and the wider community.

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Asthma and Respiratory Infections From Birth to Young Adulthood

Cited by 7 publications

References 38 publications

Occupation and occurrence of respiratory infections among adults with newly diagnosed asthma

Occupation and occurrence of respiratory infections among adults with newly diagnosed asthma

Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol

Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol

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