Asthma and obstructive sleep apnoea in adults and children – an up-to-date review

Wang, Ran; Mihăicuţă, Ştefan; Tiotiu, Angélica; Corlăteanu, Alexandru; Ioan, Iulia; Bikov, András

doi:10.1016/j.smrv.2021.101564

Cited by 47 publications

(40 citation statements)

References 99 publications

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“…Episodes of complete or partial upper airway closure in OSAS are associated with blood-gas changes and altered normal sleep architecture with long-term sequelae (29). In patients with co-existing asthma, OSAS is widely known to be associated with poor asthma control and more frequent severe exacerbations (30,31). Their co-existence is explained by common risk factors (mainly obesity and GERD) in a bidirectional relationship where an underlying pathogenetic pathway promote both upper and lower airway inflammation (31) and a neutrophilic inflammation is predominant in patients with OSAS and severe asthma (32).…”

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

“…In patients with co-existing asthma, OSAS is widely known to be associated with poor asthma control and more frequent severe exacerbations (30,31). Their co-existence is explained by common risk factors (mainly obesity and GERD) in a bidirectional relationship where an underlying pathogenetic pathway promote both upper and lower airway inflammation (31) and a neutrophilic inflammation is predominant in patients with OSAS and severe asthma (32). Moreover, repeated episodes of upper airways collapse in OSAS trigger cyclical hypoxemia and vagally-induced bronchospasm (33).…”

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

“…According to this, a more recent prospective controlled study demonstrated that adeno tonsillectomy improves asthma outcomes as measured by the Childhood Asthma Control Test C-ACT, but with only minimal improvements in the asthma clinical outcomes (41). Asthmatic children with nonfully controlled asthma or frequent nocturnal symptoms or those who have risk factors for OSAS (obesity and other comorbidities) should be evaluated to rule out an underlying sleep disorder (31).…”

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

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Do not forget asthma comorbidities in pediatric severe asthma!

et al. 2022

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Asthma is the most common chronic respiratory disease in childhood. The long-term goals in managing asthma aim to control symptoms and prevent exacerbations, as well as to reduce side effects of therapy and mortality disease-related. Most of patients have mild to moderate asthma and respond well to standard therapies. However, a minor proportion of children with asthma has severe disease that remains uncontrolled despite optimal adherence to prescribed therapy and treatment of contributory factors, including trigger exposures and comorbidities, which can mimic or worsen asthma and contribute to exacerbations and poor quality of life. Evaluation of comorbidities is fundamental to optimize the management of the disease in a subgroup of patients with poor responder asthma. The overall aim of this article is to describe characteristics of main pediatric severe asthma comorbidities reported in literature, giving clinicians tools to recognize and manage properly these conditions.

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Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 99%

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Do not forget asthma comorbidities in pediatric severe asthma!

et al. 2022

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“…It is well known that hypoxia causes cell damage followed by inflammation and HIF-1α accumulation ( Chen and Gaber, 2021 ; Shao et al, 2021 ). Inflammation is described many times as a significant pathogenic factor of OSA ( Khalyfa et al, 2018 ; Wang et al, 2022 ). At the same time, intermittent hypoxia in IHHT, IHNT, and OSA circumstances is able to increase HIF-1α expression in white blood cells ( Serebrovska et al, 2017 ; Tregub et al, 2020 ; Fitzpatrick et al, 2021 ; Nanduri et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Intermittent Hypoxia in Training Regimes and in Obstructive Sleep Apnea on Aging Biomarkers and Age-Related Diseases: A Systematic Review

Tessema

Sack

König

et al. 2022

Front. Aging Neurosci.

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Several studies have assessed the effects of intermittent hypoxia-normoxia training (IHNT), intermittent hypoxia-hyperoxia training (IHHT), and obstructive sleep apnea (OSA) on aging and age-related diseases in humans; however, the results remain contradictory. Therefore, this review aims to systematically summarize the available studies on the effects of IHNT, IHHT, and OSA on aging and age-related diseases. Relevant studies were searched from PubMed, Google Scholar, Cochrane Library databases, and through manual searching from reference lists of eligible studies. A total of 38 eligible studies were included in this systematic review. IHHT and IHNT provide positive effects on several age-related parameters including quality of life, cognitive and physical functions, plasma level of glucose and cholesterol/LDL, systolic blood pressure, red blood cells, and inflammation. Moreover, moderate intermittent hypoxia induces telomerase reverse transcriptase (TERT) activity and telomere stabilization, delays induction of senescence-associated markers expression and senescence-associated β-galactosidase, upregulates pluripotent marker (Oct4), activates a metabolic shift, and raises resistance to pro-apoptotic stimuli. On the contrary, intermittent hypoxia in OSA causes hypertension, metabolic syndrome, vascular function impairment, quality of life and cognitive scores reduction, advanced brain aging, increase in insulin resistance, plasma hydrogen peroxide, GSH, IL-6, hsCRP, leptin, and leukocyte telomere shortening. Thus, it can be speculated that the main factor that determines the direction of the intermittent hypoxia action is the intensity and duration of exposure. There is no direct study to prove that IHNT/IHHT actually increases life expectancy in humans. Therefore, further study is needed to investigate the actual effect of IHNT/IHHT on aging in humans.Systematic Review Registrationwww.crd.york.ac.uk/prospero, identifier CRD42022298499.

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“…Night sleep plays an important role in congenital and acquired immunity. Obstructive sleep apnea is a disease that naturally affects sleep and is associated with asthma outcomes [ 8 ]. Short sleep duration has strong effects on immunity, inflammatory state, and cytokine production.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Short Sleep Duration on the Development of Asthma

Song

2022

International Journal of Clinical Practice

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Asthma is regarded as a heterogeneous disease with chronic airway inflammation and reversible airway limitation. Asthma itself and recurrent attacks of asthma can decrease sleep duration and increase the prevalence of short sleep duration. Systemic low-grade inflammation and obesity caused by short sleep duration have been known for a long time, which potentially affect the development of asthma. It would be interesting to study the interaction between short sleep duration and asthma. However, there are relatively few studies and no review about the association between short sleep duration and asthma. This article performed a review about the relationships between short sleep duration and asthmatic phenotype, laboratory tests, comorbidity, and clinical outcomes. Pooled studies about short sleep duration and asthma provided following four results: (1) compared with healthy sleep duration, short sleep duration seemingly increased the risk of central obesity in asthmatics; (2) short sleep duration potentially reduced the level of FeNO and increased lung function impairment in patients with asthma; (3) asthmatic comorbidities, mainly obesity and depression, were negatively associated with short sleep duration among asthmatics; (4) short sleep duration potentially increased the risks of asthma-related hospitalization and emergency care. However, almost all studies are based on subjective but not objective sleep duration. In addition, the study on sleep duration and cause-specific mortality in patients with asthma is relatively scant. Considering the effect of short sleep duration on the development of asthma, we recommend that periodic sleep monitoring for asthmatic management is very necessary.

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Asthma and obstructive sleep apnoea in adults and children – an up-to-date review

Cited by 47 publications

References 99 publications

Do not forget asthma comorbidities in pediatric severe asthma!

Do not forget asthma comorbidities in pediatric severe asthma!

Effects of Intermittent Hypoxia in Training Regimes and in Obstructive Sleep Apnea on Aging Biomarkers and Age-Related Diseases: A Systematic Review

The Effect of Short Sleep Duration on the Development of Asthma

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