Asthma and Obesity

Manion, Amy

doi:10.1016/j.cnur.2012.12.002

Cited by 8 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although asthma affects people of all ages, it disproportionately affects children. 5 – 7 Currently, in the US, over 10 million children and adolescents have been diagnosed with asthma, making it the leading chronic childhood illness. 8 Since 1999, children 5–17 years of age have demonstrated the highest prevalence rates with 109.3 per 1000 diagnosed with asthma, compared with 76.8 per 1000 in those over 18 years of age.…”

Section: Introductionmentioning

confidence: 99%

“…Even among children, these racial differences are evident. 7 – 9 Results from the National Health Interview Survey 1997–2003 found that asthma prevalence was consistently greater among non-Hispanic black children (15.7%) compared with non-Hispanic white children (11.5%) across all levels of income. 11 In addition, non-Hispanic black children are 3.6 times more likely to use the emergency department (ED) for asthma-related issues than non-Hispanic white children.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity and asthma: Pathophysiology and implications for diagnosis and management in primary care

Mohanan

Tapp

McWilliams

et al. 2014

Exp Biol Med (Maywood)

121

View full text Add to dashboard Cite

The effects of obesity on asthma diagnosis, control, and exacerbation severity are increasingly recognized; however, the underlying pathophysiology of this association is poorly understood. Mainstream clinical practice has yet to adopt aggressive management of obesity as a modifiable risk factor in asthma care, as is the case with a risk factor like tobacco or allergen exposure. This review summarizes existing data that support the pathophysiologic mechanisms underlying the association between obesity and asthma, as well as the current and future state of treatment for the obese patient with asthma. Our review suggests that evidence of chronic inflammatory response linking obesity and asthma indicates a need to address obesity during asthma management, possibly using patient-centered approaches such as shared decision making. There is a need for research to better understand the mechanisms of asthma in the obese patient and to develop new therapies specifically targeted to this unique patient population.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obesity and asthma: Pathophysiology and implications for diagnosis and management in primary care

Mohanan

Tapp

McWilliams

et al. 2014

Exp Biol Med (Maywood)

121

View full text Add to dashboard Cite

show abstract

“…Asthma is a debilitating disease of the airways that affects over 235 million people globally [1]. Asthmatic airways sensitized to a specific allergen respond violently to subsequent exposures, resulting in asthma attacks, which can be fatal.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma

et al. 2014

View full text Add to dashboard Cite

Objective Allergic asthma is a chronic inflammatory disease of the airways characterized by excessive inflammation and remodeling of the extracellular matrix (ECM) and associated cells of the airway wall. Under inflammatory conditions, hyaluronan (HA), a major component of the ECM, undergoes dynamic changes, which may in turn affect the recruitment and activation of inflammatory cells leading to acute and chronic immunopathology of allergic asthma. Methods In the present study, we measured the changes in HA levels generated at sites of inflammation and examined its effect on inflammatory responses and collagen deposition in an Aspergillus fumigatus murine inhalational model of allergic asthma. Results We found that HA levels are elevated in allergic animals and that the increase correlated with the influx of inflammatory cells 5 days after the second allergen challenge. This increase in HA levels appeared largely due to up regulation of hyaluronidase-1 (HYAL1) and hyaluronidase-2 (HYAL2). Furthermore, HA co-localizes with areas of new collagen synthesis and deposition. Conclusions Overall our findings contribute to the growing literature that focuses on the components of ECM as inflammatory mediators rather than mere structural support products. The evidence of HA localization in fungal allergic asthma provides the impetus to study HA more closely with allergic leukocytes in murine models. Further studies examining HA’s role in mediating cellular responses may help to develop targets for treatment in patients with severe asthma due to fungal sensitization.

show abstract

“…Many women in this study felt that their weight exacerbated their health problems, and that by losing weight, they would alleviate the symptoms of multiple conditions and feel better in a global sense. Adults with asthma are more likely to be obese than those without (46) and there may be a dose-response relationship between obesity and severity of asthma symptoms (47). While evidence is mixed about whether weight loss improves asthma control (46, 48), encouraging healthy lifestyle behaviors that promote weight control may be well-received by multimorbid asthma patients who see weight loss as a means to improving their health more generally, and appropriate counseling or referrals are indicated.…”

Section: Discussionmentioning

confidence: 99%

Self-management of multiple chronic conditions among African American women with asthma: a qualitative study

Janevic¹,

Ellis²,

Sanders³

et al. 2013

Journal of Asthma

View full text Add to dashboard Cite

Objective African American women are disproportionately burdened by asthma morbidity and mortality, and may be more likely than asthma patients in general to have comorbid health conditions. This study sought to identify the self-management challenges faced by African American women with asthma and comorbidities, how they prioritize their conditions, and behaviors perceived as beneficial across conditions. Methods In-depth interviews were conducted with 25 African-American women (mean age 52 years) with persistent asthma and at least one of the following: diabetes, heart disease, or arthritis. Information was elicited on women’s experiences managing asthma and concurrent health conditions. The constant-comparison analytic method was used to develop and apply a coding scheme to interview transcripts. Key themes and subthemes were identified. Results Participants reported an average of 5.7 comorbidities. Fewer than half of the sample considered asthma their main health problem; these perceptions were influenced by beliefs about the relative controllability, predictability, and severity of their health conditions. Participants reported ways in which comorbidities affected asthma management, including that asthma sometimes took a ‘backseat’ to conditions considered more troublesome or worrisome. Mood problems, sometimes attributed to pain or functional limitations resulting from comorbidities, reduced motivation for self-management. Women described how asthma affected comorbidity management; e.g., by impeding recommended exercise. Some self-management recommendations, such as physical activity and weight control, were seen as beneficial across conditions. Conclusions Multiple chronic conditions that include asthma may interact to complicate self-management of each condition. Additional clinical attention and self-management support may help reduce multimorbidity-related challenges.

show abstract

Asthma and Obesity

Cited by 8 publications

References 39 publications

Obesity and asthma: Pathophysiology and implications for diagnosis and management in primary care

Obesity and asthma: Pathophysiology and implications for diagnosis and management in primary care

Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma

Self-management of multiple chronic conditions among African American women with asthma: a qualitative study

Contact Info

Product

Resources

About