Asthma and IgE antibodies induced by chromium and nickel salts

Hazardous air pollutants and asthma.

“…Common asthmagens identifiable by this method include metals such as cadmium (224,225), chromium (226,229), cobalt (230)(231)(232)(233), and nickel (234)(235)(236)(237)(238)(239) compounds. This method is aided by knowledge of the chemicals present in the workplace and the reversal of symptoms upon removal from the workplace.…”

Health hazard evaluation report: HETA-97-0141-2819, Special Metals Corporation, Princeton Powder Division, Princeton, Kentucky.

“…17 However, occupational asthma can occur with inhalation exposures to Cr(III) salts. 18 Cr(III) is also very poorly absorbed via dermal exposure, although absorption can be increased if the skin is broken. 17 However, biological levels of chromium are generally associated with exposure to Cr(VI) and not Cr(II) or Cr(III).…”

Direct Effect of CoCl2 and NiCl2 on Citrate Uptake by the Rat Renal Brush Border Membrane

“…Co and Ni are located in Group VIII of the periodic table, both are used as a matrix in hard metals depending on the desired properties of the final product 1,5) . In bronchial challenge tests, patients with hard metal asthma have been found to be sensitive to Co. Occupational exposure to Ni also causes asthma by allergic processes among hard metal workers 6,7) . In some hard metal asthma patients, specific IgE against Co-HSA (human serum albumin) or Ni-HSA has been reported 8) .…”