Asthma and hay fever Nonallergic bronchial hyperreactivity in asthmatic children decreases with age and increases with mite immunotherapy

Murray, Andrew B.; Ferguson, Alexander; Morrison, Brenda J.

doi:10.1016/0091-6749(86)90390-8

Cited by 11 publications

(16 citation statements)

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“…In another Swedish study, BHR increased less during the birch pollen season in an immunotherapy-treated group than in a placebo-treated group [29]. while in contrast, a Canadian study of dustmite treated children has shown a tendency toward increased BHR in treated patients compared to a control group [30]. It is thus still doubtful whether immunotherapy affects BHR.…”

Section: Discussionmentioning

confidence: 94%

Comparison of the in‐vivo and in‐vitro response to ragweed immunotherapy in children and adults with ragweed‐induced rhinitis

Hedlin

Silber

Naclerio

et al. 1990

Clin Experimental Allergy

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In order to compare results of allergen immunotherapy in paediatric and adult populations, 22 children with a history of ragweed hay fever were matched with an equal number of adults for skin sensitivity to ragweed and all were given a 1-year course of immunotherapy with a partially purified ragweed extract. Biological responses were measured by nasal challenges with ragweed before therapy was started, after 12 weekly injections and when the maintenance dose had been reached and also by methacholine bronchoprovocation tests before and after 12 months of therapy. Skin-test sensitivity to ragweed and control allergens, and ragweed-specific IgE and IgG antibody responses were measured at the same intervals as the challenges and at the end of the study. The effect of the therapy on clinical symptoms was not evaluated. Before therapy the groups of adults and children were comparable by all indices, except for TAME esterase activity in nasal washes during ragweed nasal challenge which was significantly lower in children. During treatment, mediators released during sequential nasal challenges declined to undetectable levels in most patients and changes in nasal ragweed sensitivity were comparable in both groups. Ragweed IgE increases after 12 weeks of therapy and IgG levels at maintenance therapy tended to be higher in the children, but neither difference was statistically significant. At the end of the study IgE and IgG antibody levels were comparable in both groups. Results of methacholine inhalation tests did not change significantly in either group. The decrease in skin sensitivity to ragweed was similar in both groups. We conclude that ragweed immunotherapy leads to immunological and biological consequences that are comparable in children and adults.

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Section: Discussionmentioning

confidence: 94%

Comparison of the in‐vivo and in‐vitro response to ragweed immunotherapy in children and adults with ragweed‐induced rhinitis

Hedlin

Silber

Naclerio

et al. 1990

Clin Experimental Allergy

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“…Murray et al . observed an insignificant increase of BR to histamine after HDM‐SIT, while BR decreased in subjects without SIT [ 14].…”

Section: Discussionmentioning

confidence: 99%

“…In a placebocontrolled study, Van Bever et al found no significant change of BR to histamine after one year of SIT with a standardized HDM-extract [11]. Murray et al observed an insignificant increase of BR to histamine after HDM-SIT, while BR decreased in subjects without SIT [14].…”

Section: Discussionmentioning

confidence: 99%

Effect of specific immunotherapy with house dust mite extract on the bronchial responsiveness of paediatric asthma patients

Gruber

Eber

Mileder

et al. 1999

Clin Experimental Allergy

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“…The National Institutes of Health (NIH) International Consensus Report on Diagnosis and Management and the World Health Organization (WHO)/NIH Global Initiative on Asthma Management recommend that allergen immunotherapy should only be considered when asthma is poorly controlled with drugs, and where allergen avoidance is impossible [27,28]. There has been at least one report, MURRAY et al [29], which demonstrated the enhancement of nonspecific AHR by more than two-fold after mite immunotherapy in patients with atopic asthma. Although it may be premature to apply the results of the present study directly to humans, the animal model presented in this report may help to clarify why allergen immunotherapy is not always as effective as expected.…”

Section: Discussionmentioning

confidence: 99%

Dissociation between airway responsiveness to methacholine and responsiveness to antigen

Kamachi

Nasuhara²,

Nishimura³

et al. 2002

Eur Respir J

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Dissociation between airway responsiveness to methacholine and responsiveness to antigen. A. Kamachi, Y. Nasuhara, M. Nishimura, T. Takahashi, Y. Homma, Y. Ohtsuka, M. Munakata. #ERS Journals Ltd 2002. ABSTRACT: Repeated aerosolized antigen challenges to brown Norway (BN) rats generate nonspecific airway hyperresponsiveness (AHR). On the other hand, some studies have demonstrated that repeated antigen challenge could attenuate antigenspecific AHR in BN rats. The authors questioned whether such dissociation in airway responses actually occurs when assessed in a single study in the same animals.The authors simultaneously measured AHR to methacholine and antigen-specific AHR in rats that were repeatedly exposed to aerosolized ovalbumin (OA) for 1 or 3 months after sensitization. Four days after the last challenge, airway responses to methacholine and OA, morphometry of the airways, the cell profile in bronchoalveolar lavage fluid, and cytokine messenger ribonucleic acid (mRNA) expression in the lungs were evaluated.The two types of AHR were modulated in opposite directions by repeated antigen challenges. The AHR to methacholine was significantly increased in the rats receiving antigen challenges compared with the control rats receiving saline challenges after sensitization; whereas, the antigen-specific AHR was significantly decreased. The number of alveolar macrophages in lavaged fluid and the expression of transforming growth factor-b 1 mRNA in lung tissue was significantly different between the antigenchallenged rats and the control rats.In conclusion, dissociation between nonspecific airway hyperresponsiveness and antigen-specific airway hyperresponsiveness in brown Norway rats after repeated antigen challenges was demonstrated. Sustained airway inflammation with macrophages and/or upregulation of transforming growth factor-b 1 messenger ribonucleic acid in the lung tissue may be responsible for this dissociation.

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Asthma and hay fever Nonallergic bronchial hyperreactivity in asthmatic children decreases with age and increases with mite immunotherapy

Cited by 11 publications

References 0 publications

Comparison of the in‐vivo and in‐vitro response to ragweed immunotherapy in children and adults with ragweed‐induced rhinitis

Comparison of the in‐vivo and in‐vitro response to ragweed immunotherapy in children and adults with ragweed‐induced rhinitis

Effect of specific immunotherapy with house dust mite extract on the bronchial responsiveness of paediatric asthma patients

Dissociation between airway responsiveness to methacholine and responsiveness to antigen

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