Asthma and COVID-19; different entities, same outcome: a meta-analysis of 107,983 patients

Hussein, Mohammad; Elshazli, Rami M.; Attia, Abdallah S.; Nguyen, Therese; Aboueisha, Mohamed; Munshi, Ruhul; Toraih, Eman A.; Fawzy, Manal S.; Kandil, Emad

doi:10.1080/02770903.2021.1881970

Cited by 19 publications

(14 citation statements)

References 32 publications

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“…The second strand of the literature has focused on studying the clinical outcomes of asthma patients with Covid-19. A systematic literature review finds that there was no significant difference in the combined risk of requiring admission to ICU and/or receiving mechanical ventilation for people with asthma (RR 0.87, 95% CI 0.94-1.37) and risk of death from Covid-19 (RR 0.87; 95% CI 0.68-1.10) [38].These findings are similar to the ones conducted in another meta-analysis [40,41]. Overall, the literature suggests that asthma is not an independent risk factors for the clinical outcomes of Covid-19 [36].…”

Section: Covid-19 and Asthmasupporting

confidence: 73%

Covid-19 and non-communicable diseases: evidence from a systematic literature review

Nikoloski

Alqunaibet²,

Alfawaz³

et al. 2021

BMC Public Health

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Background Since early 2020, the Covid-19 pandemic has engulfed the world. Amidst the growing number of infections and deaths, there has been an emphasis of patients with non-communicable diseases as they are particularly susceptible to the virus. The objective of this literature review is to systematize the available evidence on the link between non-communicable diseases and Covid-19. Methods We have conducted a systematic review of the literature on Covid-19 and non-communicable diseases from December, 2019 until 15th of November, 2020. The search was done in PubMed and in doing so we used a variety of searching terms in order to isolate the final set of papers. At the end of the selection process, 45 papers were selected for inclusion in the literature review. Results The results from the review indicate that patients with certain chronic illnesses such as diabetes, hypertension (and other cardiovascular diseases), chronic respiratory illnesses, chronic kidney and liver conditions are more likely to be affected by Covid-19. More importantly, once they do get infected by the virus, patients with chronic illnesses have a much higher likelihood of having worse clinical outcomes (developing a more severe form of the disease or dying) than an average patient. There are two hypothesized channels that explain this strong link between the chronic illnesses enumerated above and Covid 19: (i) increased ACE2 (angiotensin-converting enzyme 2) receptor expressions, which facilitates the entry of the virus into the host body; and (ii) hyperinflammatory response, referred to as “cytokine storm”. Finally, the literature review does not find any evidence that diabetes or hypertension related medications exacerbate the overall Covid-19 condition in chronic illness patients. Conclusions Thus, the evidence points out to ‘business as usual’ disease management model, although with greater supervision. However, given the ongoing Covid-19 vulnerabilities among people with NCDs, prioritizing them for the vaccination process should also figure high on the agenda on health authorities.

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Section: Covid-19 and Asthmasupporting

confidence: 73%

Covid-19 and non-communicable diseases: evidence from a systematic literature review

Nikoloski

Alqunaibet²,

Alfawaz³

et al. 2021

BMC Public Health

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“…A meta‐analysis of 11 studies with a pooled sample of nearly 108,000 COVID‐19 patients showed that those with asthma were more likely to be younger and obese, had an increased risk of intubation especially if <50 years old, and had longer hospital stays if <65; however, there were no significant differences in terms of comorbidities, laboratory testing, hospitalization rates, ICU admission or development of acute respiratory distress syndrome between the groups. Additionally, asthmatic patients had better recovery and were less likely to die than nonasthmatic patients (Hussein et al, 2021 ).…”

Section: Evidence Of Morbidity and Mortality Disparitiesmentioning

confidence: 99%

Pandemics, past and present: The role of biological anthropology in interdisciplinary pandemic studies

Dimka¹,

Doren

Battles

2022

American Journal of Biological Anthropology

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Biological anthropologists are ideally suited for the study of pandemics given their strengths in human biology, health, culture, and behavior, yet pandemics have historically not been a major focus of research. The COVID‐19 pandemic has reinforced the need to understand pandemic causes and unequal consequences at multiple levels. Insights from past pandemics can strengthen the knowledge base and inform the study of current and future pandemics through an anthropological lens. In this paper, we discuss the distinctive social and epidemiological features of pandemics, as well as the ways in which biological anthropologists have previously studied infectious diseases, epidemics, and pandemics. We then review interdisciplinary research on three pandemics–1918 influenza, 2009 influenza, and COVID‐19–focusing on persistent social inequalities in morbidity and mortality related to sex and gender; race, ethnicity, and Indigeneity; and pre‐existing health and disability. Following this review of the current state of pandemic research on these topics, we conclude with a discussion of ways biological anthropologists can contribute to this field moving forward. Biological anthropologists can add rich historical and cross‐cultural depth to the study of pandemics, provide insights into the biosocial complexities of pandemics using the theory of syndemics, investigate the social and health impacts of stress and stigma, and address important methodological and ethical issues. As COVID‐19 is unlikely to be the last global pandemic, stronger involvement of biological anthropology in pandemic studies and public health policy and research is vital.

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“…12 In a recent meta-analysis of 107,983 patients with COVID-19, asthmatic individuals-especially young and obese-were found to be more at risk for intubation, but ultimately had a better prognosis when compared to non-asthmatic individuals. 13 However, the majority of other studies have highlighted that asthma patients, in general, may not be at risk for severe COVID-19, which may be due to a potential protective effect of type 2 inflammation. [14][15][16] From the earliest observations, it has appeared that the course of COVID-19 is heterogeneous, varying from asymptomatic infection to severe pneumonia.…”

Section: Overall Does Asthma Increase Covid-19 Risk or Worsen The Out...mentioning

confidence: 99%

COVID-19, Severe Asthma and Omalizumab Therapy: A Case-Based Inquiry into Associations, Management, and the Possibility of a Better Outcome

Sönmez¹,

Kısakürek²,

Öztürk³

et al. 2021

Turk Thorac J

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Recent developments in research have put forward claims on the protective effect of allergic diseases-especially allergic airway inflammation including allergic asthma-against the COVID-19 pandemic. This was first suggested by the underrepresentation of asthma patients in some cohorts and was later investigated by angiotensin-converting enzyme II (ACEII) receptor expression studies. Controversial data on this matter persists and continue to be a challenge for clinicians when it comes to managing allergic diseases during the pandemic. We present in this study a thorough review of related findings so far and our own experience with 2 severe asthma patients who presented with atypical symptoms. Interestingly, both patients were administered anti-IgE therapy prior to the initial positive polymerase chain reaction (PCR) results for COVID-19 and showed no symptoms of severe respiratory disease during the infection unlike what we know from other viral respiratory illnesses. Stemming from that, we wanted to combine the perspectives of allergists and infectious disease specialists to address certain concerns in the management of allergic diseases, such as biologicals, in the light of current guidelines. We have also pointed out certain gaps in clinical and molecular level research, such as the lack of phenotypical subgroup analysis among ill asthma patients and the lack of data concerning the molecular effects of biologicals on viral infection.

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Asthma and COVID-19; different entities, same outcome: a meta-analysis of 107,983 patients

Cited by 19 publications

References 32 publications

Covid-19 and non-communicable diseases: evidence from a systematic literature review

Covid-19 and non-communicable diseases: evidence from a systematic literature review

Pandemics, past and present: The role of biological anthropology in interdisciplinary pandemic studies

COVID-19, Severe Asthma and Omalizumab Therapy: A Case-Based Inquiry into Associations, Management, and the Possibility of a Better Outcome

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