Asthma and anaphylaxis induced by royal jelly

Thien, Francis; Leung, Roland; Baldo, Brian A.; Weiner, J. A.; Plomley, Richard F.; Czarny, Daniel

doi:10.1111/j.1365-2222.1996.tb00082.x

Cited by 82 publications

(59 citation statements)

References 17 publications

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“…1,2) Recently, however, a possibility that the royal jelly might have allergenicity for food-allergy patients has been reported. 3,4) Furthermore, it was reported that the N-glycans of a bee venom allergen, phospholipase A2, bear the Fuca1-3GlcNAcb1-Asn unit, 5) which shows strong antigenicity and has been postulated to be involved in allergic symptoms caused by food or pollen glycoallergens. 6,7) To conrm whether such antigenic N-glycans occur in the royal jelly glycoproteinous component, therefore, we started the structural analysis of total N-glycans linked to glycoproteins in royal jelly.…”

mentioning

confidence: 99%

First Evidence for Occurrence of Galβ1-3GlcNAcβ1-4Man Unit inN-Glycans of Insect Glycoprotein: β1-3Gal and β1-4GlcNAc Transferases Are Involved inN…

Kimura¹,

Tsumura²,

Kimura³

et al. 2003

Bioscience, Biotechnology, and Biochemistry

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confidence: 99%

First Evidence for Occurrence of Galβ1-3GlcNAcβ1-4Man Unit inN-Glycans of Insect Glycoprotein: β1-3Gal and β1-4GlcNAc Transferases Are Involved inN…

Kimura¹,

Tsumura²,

Kimura³

et al. 2003

Bioscience, Biotechnology, and Biochemistry

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“…Skin prick tests and provocation tests with royal jelly were positive [83]. Specific IgE binding to the allergens in the protein fraction of royal jelly, particularly to 55- and 47-kDa components, has been demonstrated [84]. However, in sera of allergic controls with a history of hay fever and eczema but with no known reaction to royal jelly as well as in bee-venom-sensitized patients, a similar pattern was also observed.…”

Section: Food-related Allergic Reactions From Insect Productsmentioning

confidence: 98%

“…However, in sera of allergic controls with a history of hay fever and eczema but with no known reaction to royal jelly as well as in bee-venom-sensitized patients, a similar pattern was also observed. The 55-kDa band could correspond to an earlier described major royal jelly protein [84]. …”

Section: Food-related Allergic Reactions From Insect Productsmentioning

confidence: 99%

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Systemic Immediate Allergic Reactions to Arthropod Stings and Bites

Bircher

2005

Dermatology

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Most of the encounters with biting and stinging insects result in more or less pronounced localized reactions. Typically, urticarial wheals and papular reactions are observed. Less often local bullous or hemorrhagic or disseminated papular reactions, particularly in children and immunologically naive adults, may be seen. With the exception of bee and wasp venom allergies, immediate-type allergic reactions to arthropod stings and bites are rare. Systemic IgE-mediated hypersensitivity has also been reported from additional hymenoptera species, e.g. hornets, bumble bees and ants. Rare are systemic reactions to mosquitoes, flies or kissing bugs and exceptional from ticks, bed bugs, moths, caterpillars and spiders. A major problem is the often lacking standardization of extracts for skin testing and for the determination of specific IgE. Some of the allergens have been characterized and few of them synthesized using recombinant techniques. Most investigations have been made with whole-body extracts or extracts from salivary glands, while desensitization has rarely been attempted. Currently, primary prevention by avoidance of stings and bites, and adequate instruction of sensitized individuals in the use of emergency drugs are mandatory.

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“…9,11,12) Human safety is an important factor to consider, because RJ is consumed as a dietary supplement. In this regard, it is noteworthy that untreated RJ has been reported to cause such adverse reactions as urticaria, eczema, acute asthma and anaphylaxis, [13][14][15][16][17][18][19][20][21] although such adverse reactions rarely happen. 18,22) Rosmilah et al 17) and Leung et al 19) have reported that RJsensitive subjects possessed IgE antibodies against a number of RJ proteins.…”

mentioning

confidence: 99%