Asthma and allergic rhinitis increase respiratory symptoms in cold weather among young adults

Hyrkäs, Henna; Jaakkola, Maritta S.; Ikäheimo, Tiina M.; Hugg, Timo T.; Jaakkola, Jouni J. K.

doi:10.1016/j.rmed.2013.10.019

Cited by 45 publications

(36 citation statements)

References 33 publications

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“…1623 completed questionnaires were received (response rate 64.0%). The respondents were a representative sample of the original baseline study population as reported in another study on the 20-year follow up [27]. The questionnaire contained several sections and was partly based on questions used in the previous follow-ups and research projects [28], [29].…”

Section: Methodsmentioning

confidence: 99%

Awareness of Climate Change and the Dietary Choices of Young Adults in Finland: A Population-Based Cross-Sectional Study

2014

Self Cite

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Climate change is a major public health threat that is exacerbated by food production. Food items differ substantially in the amount of greenhouse gases their production generates and therefore individuals, if willing, can mitigate climate change through dietary choices. We conducted a population-based cross-sectional study to assess if the understanding of climate change, concern over climate change or socio-economic characteristics are reflected in the frequencies of climate-friendly food choices. The study population comprised 1623 young adults in Finland who returned a self-administered questionnaire (response rate 64.0%). We constructed a Climate-Friendly Diet Score (CFDS) ranging theoretically from −14 to 14 based on the consumption of 14 food items. A higher CFDS indicated a climate-friendlier diet. Multivariate linear regression analyses on the determinants of CFDS revealed that medium concern raised CFDS on average by 0.51 points (95% confidence interval (CI) 0.03, 0.98) and high concern by 1.30 points (95% CI 0.80, 1.80) compared to low concern. Understanding had no effect on CFDS on its own. Female gender raised CFDS by 1.92 (95% CI 1.59, 2.25). Unemployment decreased CFDS by 0.92 (95% CI −1.68, −0.15). Separate analyses of genders revealed that high concern over climate change brought about a greater increase in CFDS in females than in males. Good understanding of climate change was weakly connected to climate-friendly diet among females only. Our results indicate that increasing awareness of climate change could lead to increased consumption of climate-friendly food, reduction in GHG emissions, and thus climate change mitigation.

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Section: Methodsmentioning

confidence: 99%

Awareness of Climate Change and the Dietary Choices of Young Adults in Finland: A Population-Based Cross-Sectional Study

2014

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“…According to epidemiological surveys, a cold environmental stimulus is believed a ‘trigger’ exacerbating existing asthma symptoms, or may directly trigger asthma . Hyrkäs et al . surveyed 1623 young subjects and found that existing asthma increased the risks of all cold‐weather related respiratory symptoms.…”

Section: Introductionmentioning

confidence: 99%

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Kang

Chen

et al. 2018

Respirology

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Background and objective Studies from epidemiology suggest that ambient temperature is one of the underlying triggers and potential causes of asthma. The aim of this study was to examine the impact and the molecular mechanism of temperature‐invoked airway inflammation using an experimental model of asthma in BALB/c mice. Methods Mice were exposed to different temperature conditions (steady 26°C, 26°C/18°C cycle, 26°C/10°C cycle) and received sensitization and challenge of ovalbumin (OVA) during a 21‐day period. HC030031, a selective transient receptor potential A1 (TRPA1) channel blocker, was used to investigate the underlying mechanism of TRPA1 in ‘asthmatic’ airways. After the final OVA challenge, in vivo lung function was measured, and bronchoalveolar lavage fluid (BALF) and pulmonary inflammation were assessed. Results The temperature variations, especially the largest temperature difference (16°C), exacerbated airway inflammation in OVA‐induced mice, increasing the levels of serum total‐IgE (immunoglobulin E) and IgG1, inflammatory cells and cytokines in BALF. Analysis of histopathological changes and lung function verified that repeated exposure to very cold and changed temperatures aggravated airway hyperresponsiveness (AHR). Significant upregulation of TRPA1 expression was revealed by immunohistochemistry in the presence of the largest temperature variation (26°C/10°C cycle), while administration of HC030031 successfully inhibited TRPA1 expression, thus attenuating the asthma‐like pathological features. Conclusion Repeated exposure to temperature variation exacerbated experimental ‘asthma’ and TRPA1 mediated this temperature‐dependent inflammatory effect.

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“…Cold air induces respiratory inflammation in high-altitude region or in winter (Koskela 2007). especially in patients with respiratory disorders (Seys et al 2013;Hyrkäs et al 2014). At addition, reactive oxygen species are involved in physiological and pathophysiological processes in the lung (Al Ghouleh et al 2011).…”

Section: Resultsmentioning

confidence: 99%

Cold stress increases reactive oxygen species formation via TRPA1 activation in A549 cells

Sun

Wang

Cao

et al. 2016

Cell Stress and Chaperones

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Reactive oxygen species (ROS) are responsible for lung damage during inhalation of cold air. However, the mechanism of the ROS production induced by cold stress in the lung is still unclear. In this work, we measured the changes of ROS and the cytosolic Ca 2+ concentration ([Ca 2+ ] c ) in A549 cell. We observed that cold stress (from 20 to 5°C) exposure of A549 cell resulted in an increase of ROS and [Ca 2+ ] c , which was completely attenuated by removing Ca 2+ from medium. Further experiments showed that cold-sensing transient receptor potential subfamily member 1 (TRPA1) agonist (allyl isothiocyanate, AITC) increased the production of ROS and the level of [Ca 2+ ] c in A549 cell. Moreover, HC-030031, a TRPA1 selective antagonist, significantly inhibited the enhanced ROS and [Ca 2+ ] c induced by AITC or cold stimulation, respectively. Taken together, these data demonstrated that TRPA1 activation played an important role in the enhanced production of ROS induced by cold stress in A549 cell.

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Asthma and allergic rhinitis increase respiratory symptoms in cold weather among young adults

Cited by 45 publications

References 33 publications

Awareness of Climate Change and the Dietary Choices of Young Adults in Finland: A Population-Based Cross-Sectional Study

Awareness of Climate Change and the Dietary Choices of Young Adults in Finland: A Population-Based Cross-Sectional Study

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Cold stress increases reactive oxygen species formation via TRPA1 activation in A549 cells

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