Asthma and allergic diseases: is there a downside to cleanliness and can we exploit it?

Crane, James W.

doi:10.1038/sj.ejcn.1601660

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…As a result, probiotics may be a promising and practical exposure that may lead to a Th phenotype that is not associated with atopic conditions. 112 A double-blind, randomized, controlled trial of 62 mother-infant pairs to evaluate the effect of probiotic supplementation to the pregnant and lactating mothers suggested that probiotic supplementation decreased the infant's risk of developing atopic eczema during the first 2 years of life. 113,114 Extended follow-up of the cohort suggests that such effects are sustained past infancy.…”

Section: Primary Preventionmentioning

confidence: 99%

Probiotic and Prebiotic Influence Beyond the Intestinal Tract

et al. 2008

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Probiotics and prebiotics have long been appreciated for their positive influences on gut health. Research on the mechanisms and effects of these agents shows that their impact reaches beyond the intestine. Effects on the microecology and pathology of the oral cavity, stomach, and vaginal tract have been observed. Likely mediated through immune influences, systemic effects such as reduced severity of colds or other respiratory conditions, impact on allergy incidence and symptoms, and reduced absences from work or daycare have also been noted. These observations, among others, suggest a broader spectrum of influence than commonly considered for these unique substances.

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Section: Primary Preventionmentioning

confidence: 99%

Probiotic and Prebiotic Influence Beyond the Intestinal Tract

et al. 2008

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“…Recent studies suggest that antibiotics in the first few years of life have been associated with increased risks of allergic disease in later childhood 14. Some studies have shown that exposure and use of antibiotics in infants may increase the risk of AR or asthma 5,6,15,16.…”

Section: Discussionmentioning

confidence: 99%

<p>Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China</p>

Chen¹,

Sng²,

Wang³

et al. 2019

TCRM

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Background Several studies have shown that the use of antibiotics early in life significantly increases the risk of asthma in children. It is unclear whether antibiotics are more commonly used in patients with allergy-related diseases. Methods A multistage, clustered and random sampling with a field-interviewer-administrated survey study was performed to investigate if there was multiple use of antibiotics (MUA) in patients with allergic rhinitis (AR), conjunctivitis, chronic urticaria (CU), and asthma in the grasslands of northern China. MUA was defined as antibiotic usage for at least 3 days and for more than 3 times a year in the past 2 years. Results A total of 5,787 subjects completed the study, with 1,079 subjects (18.6%) identified as MUA. MUA was more common in patients with AR (23.7% vs 16.2%, P <0.001), conjunctivitis (22.5% vs 17.1%, P <0.001), asthma (31.8% vs 17.7%, P <0.001), and CU (25.9% vs 18.3%, P <0.01) than in subjects without allergic diseases. There is an increasing percentage of MUA in patients with a single, two, and three or more diseases both in children (20.1%, 25.0%, and 31.4%, respectively, P =0.014) and in adults (19.1%, 23.4%, and 32.9%, respectively, P <0.001). MUA is significantly associated with AR (OR=1.7, 95% CI: 1.3–2.1, P <0.001), conjunctivitis (OR=1.6, 95% CI: 1.2–2.1, P =0.001), asthma (OR=2.3, 95% CI:1.6–3.3, P <0.001) and CU (OR=2.1, 95% CI: 1.2–3.6, P =0.006) in children aged 2–17 years; and in adults (≥18 years old) for AR (OR=1.7, 95% CI: 1.4–2.1, P <0.001), conjunctivitis (OR=1.3, 95% CI:1.1–1.6, P =0.002), and asthma (OR=2.0, 95% CI: 1.5–2.7, P <0.001). Conclusion Antibiotic overuse might be associated with increased risk of allergy-related disease. It is important that implementation of the evidence-based international guidelines for the management of allergy-related diseases needs to be improved, in order to avoid unnecessary use of antibiotics.

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“…VOL. 11,2004 TGEV AND CONCOMITANT IMMUNE RESPONSES 341 on April 30, 2020 by guest http://cvi.asm.org/ responses after immunization. This effect could be attributable to a difference in Th1 or Th2 dependence of the two isotypes: several previous studies in mice have demonstrated an easier induction of Th1 tolerance by feeding (13).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, viral infections have been implicated in the onset of other inappropriate responses, such as autoimmunity (19). Alternatively, there is increasing evidence that early life exposure to commensal and pathogenic organisms may protect humans against subsequent allergic disease (11,21,27).…”

mentioning

confidence: 99%

Effects of Infection with Transmissible Gastroenteritis Virus on Concomitant Immune Responses to Dietary and Injected Antigens

Bailey

Haverson

Miller

et al. 2004

Clin Vaccine Immunol

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Normal piglets weaned onto soy-or egg-based diets generated antibody responses to fed protein. Concurrent infection with transmissible gastroenteritis virus (TGEV) did not affect the responses to dietary antigens at weaning, nor did it affect the subsequent development of tolerance. However, TGEV infection did enhance the primary immunoglobulin M (IgM) and IgG1, but not IgG2, antibody responses to injected soy in comparison to those of uninfected animals. Paradoxically, TGEV-infected animals showed an enhanced primary IgG1 antibody response to injected soy at 4 weeks of age, but they subsequently showed a reduced secondary response after an intraperitoneal challenge at 9 weeks of age in comparison to uninfected animals. The results suggest that an enteric virus, either used as a vaccine vector or present as a subclinical infection, may not have significant effects on the development of dietary allergies but may have effects both on the primary response and on the subsequent recall response to systemic antigens to which the animal is exposed concurrently with virus antigens.

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Asthma and allergic diseases: is there a downside to cleanliness and can we exploit it?

Cited by 7 publications

References 24 publications

Probiotic and Prebiotic Influence Beyond the Intestinal Tract

Probiotic and Prebiotic Influence Beyond the Intestinal Tract

<p>Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China</p>

Effects of Infection with Transmissible Gastroenteritis Virus on Concomitant Immune Responses to Dietary and Injected Antigens

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