Asthma

Pinnock, Hilary; Shah, Rupal

doi:10.1136/bmj.39140.634896.be

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Patients with acute asthma exacerbations in the ED may perform conventional PEF measurements, if done at all. Even though PEF is promoted as a standard measurement tool for asthma (1,2), only 47% (24) of our subjects (51) had previously used this tool, even though they had established diagnoses of asthma. This suggests that peak flow meter usage is not as common as would be hoped or recommended, as has been shown in multiple previous studies (4).…”

Section: Discussionmentioning

confidence: 99%

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Correlation of a Unique “Los Angeles” Phonospirometry Technique with Peak Expiratory Flows in Children with Asthma

2012

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Section: Discussionmentioning

confidence: 99%

“…The measurement of peak expiratory flow (PEF) with a peak flow meter has been recommended as an objective technique to assess the severity of exacerbations (1,2). Peak flow meters are portable and inexpensive, and yield reproducible results.…”

Section: Introductionmentioning

confidence: 99%

Correlation of a Unique “Los Angeles” Phonospirometry Technique with Peak Expiratory Flows in Children with Asthma

2012

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“…Current use of telehealth technologies in respiratory medicine is limited; 2 evidence for their effective use is accruing, [8][9][10][11][12][13][14][15][16][17][18][19] but there remain concerns about clinical and cost effectiveness. 7,17 These issues will be affected by the setting in which telehealth is deployed.…”

Section: Discussionmentioning

confidence: 99%

“…5 However, while recent articles have discussed the potential for telehealth in respiratory disease, they have also pointed out a lack of published robust evidence of clinical and economic benefit. 2,6,7 The feasibility of telecare and telemonitoring for COPD and asthma has been demonstrated, [8][9][10][11][12] and telemonitoring has been reported to reduce hospital admissions, emergency department visits and length of stay. 13,14 Remote monitoring of chemotherapy by mobile phone has also proven successful in lung cancer management.…”

Section: Introductionmentioning

confidence: 99%

Rational development of telehealth to support primary care respiratory medicine: patient distribution and organisational factors

Godden

King

2011

Primary Care Respiratory Journal

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Aims: Telehealth may offer opportunities to support primary and secondary care of patients with respiratory disease. This study examined the potential for applying telehealth in a region of the UK by exploring the distribution of patients and examining attitudes to implementation of telehealth. Methods:The distribution of patients with asthma, COPD, lung cancer and obstructive sleep apnoea (OSAS) in the NHS Highland Region (309,900 residents, 12,507 square miles) was determined from Quality and Outcomes Framework data and disease registers. Qualitative interviews with health professionals (n=20) focussing on the potential for telehealth in respiratory medicine were analysed using the Normalisation Process Model. Results:The most remote general practices accounted for 40% of patients with asthma (7198/17822), 45% of those with COPD (2145/4721), 33% of lung cancer (199/605) and 35% of OSAS (169/489) patients. Urban figures were 28% of asthma patients, 26% of COPD patients, 25% of lung cancer and 31% of OSAS patients. Interviewees identified a range of telehealth applications they considered potentially beneficial including management, information and communication systems. However, they also identified challenges -mainly related to training, costs and infrastructure.Conclusions: Tailoring telehealth to support management of respiratory diseases in primary care requires knowledge of patient distribution, which will impact on the nature and feasibility of services. Individual and organisational capacities and attitudes are also likely to influence successful implementation.

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“…Asthma is one of the most common chronic diseases in the world. 1 According to the World Health Organization, there are more than 300 million people suffering from asthma in the world, 2 which places a heavy burden on global health and economy.…”

Section: Introductionmentioning

confidence: 99%

MiR-21-5p in Macrophage-Derived Exosomes Targets Smad7 to Promote Epithelial Mesenchymal Transition of Airway Epithelial Cells

Yang

Cheng

et al. 2021

JAA

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Background: Asthma is usually associated with airway inflammation and airway remodeling. Epithelial mesenchymal transition (EMT) often occurs in airway remodeling. The purpose of this study is to identify the effect of miR-21-5p and Smad7 signaling pathway in macrophage-derived exosomes on EMT of airway epithelial cells. Methods: HE staining and Masson staining were used to verify the successful establishment of the asthma model. The levels of epithelial cell adhesion factor and stromal cell markers were detected by Western blot. The levels of miR-21-5p were detected by qRT-PCR. The expression of miR-21-5p in lung tissue was further verified by fluorescence in situ hybridization (FISH). Exosome morphology was observed by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). Luciferase reporter assay was applied to analyze the interaction of miR-21-5p with Smad7. Results: The expression of miR-21-5p was upregulated in macrophages of rats in vivo with OVA-induced asthma. In vitro cultured alveolar macrophages stimulated by LPS could secrete exosomes with high levels of miR-21-5p. The exosome-derived miR-21-5p promotes EMT in rat tracheal epithelial cells through TGFβ1/Smad signaling pathway by downregulating Smad7. This process can be blocked by miR-21-5p inhibitor. Conclusion: Rat alveolar macrophages produced high levels of miR-21-5p-containing exosomes, which transported miR-21-5p to tracheal epithelial cells, thus promoting EMT through TGF-β1/Smad signaling pathway by targeting Smad7.

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Asthma

Cited by 9 publications

References 4 publications

Correlation of a Unique “Los Angeles” Phonospirometry Technique with Peak Expiratory Flows in Children with Asthma

Correlation of a Unique “Los Angeles” Phonospirometry Technique with Peak Expiratory Flows in Children with Asthma

Rational development of telehealth to support primary care respiratory medicine: patient distribution and organisational factors

MiR-21-5p in Macrophage-Derived Exosomes Targets Smad7 to Promote Epithelial Mesenchymal Transition of Airway Epithelial Cells

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