Asthma 17q21 polymorphism associates with decreased risk of COVID‐19 in children

Gourari, Ioulia; Gomi, Rika; Young, Madeline; Jordan, Geancarlo; Liongson, Madeline; Heras, Andrea; Gerber, Linda M.; Thomas, Charlene; Tsirilakis, Kalliope; Ono, Jennie G.; Narula, Pramod; Ketas, Thomas J.; Moore, John P.; Worgall, Stefan; Permaul, Perdita

doi:10.1002/ppul.26091

Pediatric Pulmonology

2022

DOI: 10.1002/ppul.26091

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Asthma 17q21 polymorphism associates with decreased risk of COVID‐19 in children

Ioulia Gourari

Rika Gomi

Madeline Young

et al.

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2022

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Cited by 2 publications

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“…Dear Editor, we would like to share ideas on the publication “Asthma 17q21 Polymorphism Associates with Decreased Risk of COVID‐19 in Children. 1 ” Gourari et al reported that Severe Acute Respiratory Syndrome Coronavirus‐2 infection in children rarely results in severe disease and studied the influence of asthma 17q21 polymorphism associates. 1 …”

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“… 1 ” Gourari et al reported that Severe Acute Respiratory Syndrome Coronavirus‐2 infection in children rarely results in severe disease and studied the influence of asthma 17q21 polymorphism associates. 1 …”

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confidence: 99%

“…17q21 Polymorphism Associates with Decreased Risk of COVID-19 in Children. 1 " Gourari et al reported that Severe Acute Respiratory Syndrome Coronavirus-2 infection in children rarely results in severe disease and studied the influence of asthma 17q21 polymorphism associates. 1 We are all in agreement that the genetic mutation under investigation may be significant in terms of potential therapeutic benefit.…”

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confidence: 99%

“…1 " Gourari et al reported that Severe Acute Respiratory Syndrome Coronavirus-2 infection in children rarely results in severe disease and studied the influence of asthma 17q21 polymorphism associates. 1 We are all in agreement that the genetic mutation under investigation may be significant in terms of potential therapeutic benefit. It should be noted that other factors may also have an impact on the presence of specific diseases.…”

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confidence: 99%

“…Dear Editor, we would like to share ideas on the publication “Asthma 17q21 Polymorphism Associates with Decreased Risk of COVID‐19 in Children 1 1 …”

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Asthma 17q21 polymorphism and risk of COVID‐19 in children: Correspondence

Mungmunpuntipantip¹,

Wiwanitkit

2022

Pediatric Pulmonology

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“…Dear Editor, we would like to share ideas on the publication “Asthma 17q21 Polymorphism Associates with Decreased Risk of COVID‐19 in Children 1 1 …”

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confidence: 99%

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Asthma 17q21 polymorphism and risk of COVID‐19 in children: Correspondence

Mungmunpuntipantip¹,

Wiwanitkit

2022

Pediatric Pulmonology

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The association between pre‐existing asthma and reduced risk of death among children and adolescents hospitalized with COVID‐19 in Brazil

Oliveira

Colosimo²,

Vasconcelos

et al. 2022

Pediatric Pulmonology

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Objective There have been conflicting reports on the relationship between asthma and COVID‐19 severity. This study aimed to compare the risk of death among children with asthma and healthy peers hospitalized due to COVID‐19. Methods We carried out an analysis of all pediatric patients 2–19 years of age with asthma and COVID‐19 registered in Influenza Epidemiological Surveillance Information System‐Gripe, a Brazilian nationwide surveillance database, between February 2020 and March 2022. The primary outcome was time to death, which was evaluated considering discharge as a competitive risk using the cumulative incidence function. Results Among 30,405 hospitalized children with COVID‐19, 21,340 (70.2%) had no comorbidities, 6444 (21.2%) had comorbidities other than asthma, 2165 (7.1%) had asthma, and 465 (1.5%) had asthma with other comorbidities. The estimated probability of a fatal outcome for each group was 4.1%, 14.9%, 2.1%, and 10.7%, respectively. After adjustment, children with asthma had a 60% reduction in the hazard of death than healthy peers (hazard ratio [HR] = 0.39, 95% confidence interval [CI], 0.29–0.53, p < 0.0001). Among children with asthma and no other comorbidities, two covariates were independently associated with in‐hospital mortality, age ≥12 years, HR = 4.0, 95% CI, 2.5–6.4), and low oxygen saturation at admission (HR = 2.3, 95% CI, 1.4–3.2). Conclusion Children with asthma and no comorbidities had a lower risk of death compared with healthy peers after controlling for clinical and demographic confounding factors.

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Asthma 17q21 polymorphism associates with decreased risk of COVID‐19 in children

Cited by 2 publications

References 12 publications

Asthma 17q21 polymorphism and risk of COVID‐19 in children: Correspondence

Asthma 17q21 polymorphism and risk of COVID‐19 in children: Correspondence

The association between pre‐existing asthma and reduced risk of death among children and adolescents hospitalized with COVID‐19 in Brazil

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