Asteroid Hyalitis: A study of Serum Calcium Levels in Affected Patients

Ed, Jervey; Wb, Anderson

doi:10.1097/00007611-196502000-00010

Cited by 19 publications

(9 citation statements)

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“…Moreover, racial differences between Westerners and Koreans, differences in dietary habits, and/or environmental parameters could be the difference factor. Some reports claim that AH is more prevalent in white populations, 11,19 but no report has compared the prevalence of AH in Asian people with AH frequency in Westerners. As we diagnosed AH by fundus photography, our detection sensitivity may be lower than that of autopsy.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of and Risk Factors for Asteroid Hyalosis in Seoul, Korea

Kim

Roh

Byeon

et al. 2008

Retina

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Section: Discussionmentioning

confidence: 99%

“…11 Whereas some authors have recommended testing for diabetes and high cholesterol when AH is observed in a patient, 2,9,10,17 other studies have not supported such testing. [11][12][13]18 The purpose of this study was to estimate the prevalence of AH in Seoul, Korea, and to determine the risk factors associated with AH. …”

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confidence: 99%

Prevalence of and Risk Factors for Asteroid Hyalosis in Seoul, Korea

Kim

Roh

Byeon

et al. 2008

Retina

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“…In our study, AH was not associated with systemic parameters of body height (P=0.566), weight (P=0. 5 , hypercholesterolemia 5 , hypertension 3 , hypercalcemia 21 and gout 13 . Many of these studies have been case series, case-control studies, or performed in clinic populations and may reveal a selection bias for diseases that are more prevalent in patients presenting for ophthalmic and vitreoretinal evaluations.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and Associations of Asteroid Hyalosis: The Beijing Eye Study

Zhang

Shao

Dong

et al. 2021

Preprint

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Background: To determine the prevalence and associations of asteroid hyalosis (AH) in a Chinese population-based cohort.Methods: The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). AH is a condition in which small yellow-white, spherical particles known as asteroid bodies (ABs) are present within the vitreous body.Results: Fundus photographs were gradable in 3419 subjects. AH was detected in 65 (0.9%, 95% CI: 0.7%, 1.2%) eyes of 53 (1.5%, 95% CI: 1.1%, 1.9%) subjects. AH was bilateral in 18.9%. Mean age of all subjects with AH was 69.2± 9.5 years (median, 71.0 years; range, 51–91 years), mean refractive error was 0.63±1.53D (median, 0.75 D; range, -4.12 to 4.00D). In multivariate analysis, prevalence of AH was associated with elder age (P=0.014, OR 1.057), thicker lens (P=0.034, OR 3.843), higher refractive error (P=0.016, OR 1.401).Conclusions: In adult Chinese in Beijing, the prevalence of AH was 0.9% for eyes or 1.5% for subjects. AH was associated with elder age, thicker lens and higher refractive error. It does not support previous observations of an association of AH with diabetes or other systemic indicators.

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“…18,19 Of these, a link to DM is most often cited; however, this link is also the most controversial. Although AH predominantly occurs unilaterally, 4-6 AH should be bilateral if linked to systemic diseases such as DM because each eye is equally exposed to hyperglycaemia.…”

Section: Pathogenesis Of Ahmentioning

confidence: 99%

Asteroid hyalosis: pathogenesis and prospects for prevention

Kador

Wyman

2008

Eye

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Asteroid hyalosis (AH) is a common degenerative process in which fatty calcium globules collect within the vitreous humour. The condition rarely causes visual disturbances, and surgical removal is only rarely required. The presence of AH has been associated with systemic diseases such as diabetes; however, research in this area has been hampered by the lack of an animal model of AH. Recently, we have reported that AH occurs in galactose-fed beagles that develop the advanced stages of diabetes-like retinopathy. Comparisons of vitreous humour containing asteroid bodies (ABs) collected from these galactose-fed beagles and vitreous samples from age-matched normal beagles without ABs indicate that ABs contain calcium and phosphorous. Subtraction analysis of chloroform extracts of the vitreous samples by electrospray mass spectroscopy resulted in the identification of the quasimolecular ion of 1,2-dipalmitoyl-glycero-3-phosphoethanolamine (DPPE) as the main component of ABs. Since several reports indicate that ABs are composed of lipid-calcium complexes, we have proposed that the main component of ABs in the galactose-fed dogs with AH is a quasimolecular ion of DPPE in which two molecules of DPPE are complexed through their phosphates groups with calcium. We suggest that these lipid components diffuse into the vitreous from the degenerating retinas of these dogs.

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Asteroid Hyalitis: A study of Serum Calcium Levels in Affected Patients

Cited by 19 publications

References 0 publications

Prevalence of and Risk Factors for Asteroid Hyalosis in Seoul, Korea

Prevalence of and Risk Factors for Asteroid Hyalosis in Seoul, Korea

Prevalence and Associations of Asteroid Hyalosis: The Beijing Eye Study

Asteroid hyalosis: pathogenesis and prospects for prevention

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