Asteatotic eczema (‘eczema craquelé’) with histopathological interface dermatitis: a new cutaneous reaction following pemetrexed

Frouin, Éric; Sébille, G.; Freudenberger, S.; Menecier, B.; Quoix, Élisabeth; Cribier, B.; Lipsker, Dan

doi:10.1111/j.1365-2133.2011.10777.x

Cited by 12 publications

(3 citation statements)

References 11 publications

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“…Allergic clinical symptoms are variable and unpredictable. Systemic reactions, skin toxicities including eczema, urticaria, pruritus, and erythema, or more serious effects, such as bullous skin lesions, angioedema or anaphylaxis, can occur . HR symptoms may begin during infusion or within minutes to days after IV administration, even though the same substance is administered to the same patient .…”

Section: What Is Known and Objectivementioning

confidence: 99%

Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service

Capelle

Tummino

Greillier³

et al. 2017

J Clin Pharm Ther

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Skin tests could be used to diagnose hypersensitivity reactions with platinum salts or to evaluate the possibility of cross-reactions between two platinum salts. A negative skin test may predict with reasonable reliability the absence of future hypersensitivity reactions in case of reintroduction of drug infusion. Because the IgE-mediated mechanism has never been demonstrated for pemetrexed, skin tests are not valid and have no diagnostic value for this molecule. Because hypersensitivity reactions are potentially fatal adverse events, we recommend that patients who experience a hypersensitivity reactions onset should be monitored closely and clinicians must be aware of hypersensitivity reaction signs.

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Section: What Is Known and Objectivementioning

confidence: 99%

Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service

Capelle

Tummino

Greillier³

et al. 2017

J Clin Pharm Ther

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show abstract

“…De rares cas de syndrome de Lyell [14], de radiodermite [15], d'hyperpigmentation diffuse avec desquamation ou d'oedème palpébral [16] ont été décrits. Plus récemment, trois cas de d'eczéma craquelé survenant 5 à 7 jours après que l'introduction du pemetrexed ont été rapportés [17].…”

Section: Discussionunclassified

Sclérose cutanée des deux membres inférieurs sous pemetrexed

Corbaux

Marie²,

Méraud³

et al. 2015

Annales de Dermatologie et de Vénéréologie

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“…3 Cases of more severe CARs have also been reported including toxic epidermal necrolysis, asteatotic eczema, radiation recall dermatitis, pityriasis lichenoides, acute generalized exanthematous pustulosis and pseudocellulitis, which typically manifests bilaterally. 2,[4][5][6][7][8][9] Here we present a case of unilateral pemetrexed-induced pseudocellulitis.…”

mentioning

confidence: 94%

Unilateral Pemetrexed-induced Pseudocellulitis Mimicking Bacterial Cellulitis

et al. 2018

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Pseudocellulitis, manifesting as erythema, warmth, and tenderness of the lower extremities, is a recently recognized cutaneous adverse reaction (CAR) associated with the use of pemetrexed, a multi-targeted folate antagonist. This reaction typically manifests bilaterally, helping to distinguish pemetrexed-induced pseudocellulitis from a bacterial cellulitis. We present a case of unilateral pemetrexed-induced pseudocellulitis. The patient was initially treated for cellulitis but failed to respond adequately to antibiotics, prompting a biopsy that showed the characteristic findings of pemetrexed-induced pseudocellulitis. Pemetrexed-induced pseudocellulitis is important to recognize as it may be dose-limiting or necessitate treatment modification. Furthermore, increased awareness of this CAR can help clinicians avoid unnecessary antibiotic use.

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Asteatotic eczema (‘eczema craquelé’) with histopathological interface dermatitis: a new cutaneous reaction following pemetrexed

Cited by 12 publications

References 11 publications

Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service

Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service

Sclérose cutanée des deux membres inférieurs sous pemetrexed

Unilateral Pemetrexed-induced Pseudocellulitis Mimicking Bacterial Cellulitis

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