Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis

Shen, Dongfang; Qi, Hui-Ping; Ma, Chi; Chang, Mingxiu; Zhang, Weina; Song, Rui

doi:10.1016/j.neures.2020.04.003

Cited by 38 publications

(26 citation statements)

References 35 publications

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“…Alpha synuclein (SNCA) is a major causative gene that responsible for the onset of PD. Astaxanthin could protect against PD-caused neuron damage by targeting miR-7/SNCA axis to suppress endoplasmic reticulum (ER) stress ( Table 1 ) [ 51 ]. The effects of DHA-astaxanthin (DHA-acylated astaxanthin ester), non-esterified astaxanthin and DHA + astaxanthin (combination of non-esterified astaxanthin with DHA) on PD were investigated in mice with PD.…”

Section: The Anti-inflammatory Effects Of Astaxanthin In Chronic Amentioning

confidence: 99%

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions

2020

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Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin has gained growing interest as a multi-target pharmacological agent against various diseases. In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described. Furthermore, the applications of anti-inflammatory effects of astaxanthin in neurological diseases, diabetes, gastrointestinal diseases, hepatic and renal diseases, eye and skin disorders, are highlighted. In addition to the protective effects of astaxanthin in various chronic and acute diseases, we also summarize recent advances for the inconsistent roles of astaxanthin in infectious diseases, and give our view that the exact function of astaxanthin in response to different pathogen infection and the potential protective effects of astaxanthin in viral infectious diseases should be important research directions in the future.

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Section: The Anti-inflammatory Effects Of Astaxanthin In Chronic Amentioning

confidence: 99%

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions

2020

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“…Astaxanthin lowers intracellular ROS and improves superoxide dismutase and catalase activity, and treatment with astaxanthin prevents apoptotic death in MPTP challenged SH-SY5Y cells [ 100 ]. Astaxanthin attenuates MPTP-induced neuronal injury via the downregulation of α-synuclein [ 83 ]. miR-7 directly binds to the 3′ UTR of α-synuclein mRNA and decreases the translation of α-synuclein [ 184 ].…”

Section: Neuroprotective Dietary Antioxidantsmentioning

confidence: 99%

“…miR-7 directly binds to the 3′ UTR of α-synuclein mRNA and decreases the translation of α-synuclein [ 184 ]. Treatment with astaxanthin prevents the loss of miR-7 to lower the toxic effects of α-synuclein in SH-SY5Y cells [ 83 ]. Although clinical trials are lacking, oral supplementation with astaxanthin prevents loss of neurons in the SNpc and tyrosine hydroxylase-positive cells in the striatum from intraperitoneally injected MPTP in mice [ 131 ].…”

Section: Neuroprotective Dietary Antioxidantsmentioning

confidence: 99%

Dietary Antioxidants and Parkinson’s Disease

Park

Ellis

2020

Antioxidants

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Parkinson’s disease (PD) is a neurodegenerative disorder caused by the depletion of dopaminergic neurons in the basal ganglia, the movement center of the brain. Approximately 60,000 people are diagnosed with PD in the United States each year. Although the direct cause of PD can vary, accumulation of oxidative stress-induced neuronal damage due to increased production of reactive oxygen species (ROS) or impaired intracellular antioxidant defenses invariably occurs at the cellular levels. Pharmaceuticals such as dopaminergic prodrugs and agonists can alleviate some of the symptoms of PD. Currently, however, there is no treatment to halt the progression of PD pathology. Due to the nature of PD, a long and progressive neurodegenerative process, strategies to prevent or delay PD pathology may be well suited to lifestyle changes like dietary modification with antioxidant-rich foods to improve intracellular redox homeostasis. In this review, we discuss cellular and genetic factors that increase oxidative stress in PD. We also discuss neuroprotective roles of dietary antioxidants including vitamin C, vitamin E, carotenoids, selenium, and polyphenols along with their potential mechanisms to alleviate PD pathology.

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“…Astaxanthin has been found to be more protective for mitochondrial membranes than alpha-tocopherol [218,219]. Rodent and cell culture studies with astaxanthin show that it provides protection from the mitochondrial toxins typically used to induce a PD syndrome in rodents [220][221][222][223][224]. Hence, it may be reasonable to include supplemental astaxanthin in a regimen intended for PD prevention and control.…”

Section: Scavenging Peroxynitrite-derived Radicals-benefits Of Supplementioning

confidence: 99%

Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson’s Disease

McCarty

Lerner

2020

IJMS

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Parkinson’s disease (PD) is a chronic low-grade inflammatory process in which activated microglia generate cytotoxic factors—most prominently peroxynitrite—which induce the death and dysfunction of neighboring dopaminergic neurons. Dying neurons then release damage-associated molecular pattern proteins such as high mobility group box 1 which act on microglia via a range of receptors to amplify microglial activation. Since peroxynitrite is a key mediator in this process, it is proposed that nutraceutical measures which either suppress microglial production of peroxynitrite, or which promote the scavenging of peroxynitrite-derived oxidants, should have value for the prevention and control of PD. Peroxynitrite production can be quelled by suppressing activation of microglial NADPH oxidase—the source of its precursor superoxide—or by down-regulating the signaling pathways that promote microglial expression of inducible nitric oxide synthase (iNOS). Phycocyanobilin of spirulina, ferulic acid, long-chain omega-3 fatty acids, good vitamin D status, promotion of hydrogen sulfide production with taurine and N-acetylcysteine, caffeine, epigallocatechin-gallate, butyrogenic dietary fiber, and probiotics may have potential for blunting microglial iNOS induction. Scavenging of peroxynitrite-derived radicals may be amplified with supplemental zinc or inosine. Astaxanthin has potential for protecting the mitochondrial respiratory chain from peroxynitrite and environmental mitochondrial toxins. Healthful programs of nutraceutical supplementation may prove to be useful and feasible in the primary prevention or slow progression of pre-existing PD. Since damage to the mitochondria in dopaminergic neurons by environmental toxins is suspected to play a role in triggering the self-sustaining inflammation that drives PD pathogenesis, there is also reason to suspect that plant-based diets of modest protein content, and possibly a corn-rich diet high in spermidine, might provide protection from PD by boosting protective mitophagy and thereby aiding efficient mitochondrial function. Low-protein diets can also promote a more even response to levodopa therapy.

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Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis

Cited by 38 publications

References 35 publications

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions

Dietary Antioxidants and Parkinson’s Disease

Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson’s Disease

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