Astaxanthin-producing strain breeding by genome shuffling

A genome shuffling-generated Saccharomyces cerevisiae isolate that ferments xylose and glucose to produce high levels of ethanol

“…Yu et al [25] recently used genome shuZing to improve the glucose tolerance of L. rhamnosus while simultaneously enhancing this strain's L-lactic acid production. Additionally, the yields of other biochemical products, such as Table 4 Xylose and glucose fermentation by diVerent strains Data are expressed as the mean values § standard deviation of at least three independent experiments A glucose in the mixed sugars, B xylose in the mixed sugars, C utilization of glucose in the mixed sugars, D utilization of xylose in the mixed sugars, E production of xylitol in the mixed sugars, F production of ethanol in the mixed sugars, G ethanol yield in the mixed sugars, H production of ethanol when using glucose as the sole carbon source astaxanthin [29], taxol [28], ethanol [3,6,12], and bioinsecticide [13], were also successfully increased following genome shuZing modiWcations. In this report we demonstrated the eVectiveness of genome shuZing to improve the xylose metabolic pathways in S. cerevisiae for the Wrst time.…”