Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers

Zhang, Lin; Chen, Hao; Ding, Kaiyue; He, Shiyong; Li, Guangxing; Qu, Jialin; Qiao, Yujie; Zhang, Liu; Sui, Xue; Fan, Chao; Wen, Jyh‐Horng; Wu, Wei; Gao, Zhengnan; Shang, Dong

doi:10.1016/j.jff.2021.104823

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Clinical studies have shown that ASTX intake reduces the levels of systemic inflammatory biomarkers [52,53] and potentiates the pain-relieving effect of anti-inflammatory therapies [54]. The pharmacological effects of ASTX derive from its strong antioxidantactivity mediated via ROS quenching [55] (Figure 2G, top panel) and direct free radical scavenging [56,57] (Figure 2G, bottom panel).…”

Section: Astaxanthin: the Red Gold Of Algaementioning

confidence: 99%

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

Cutolo,

Caferri,

Campitiello

et al. 2023

Marine Drugs

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Rheumatoid arthritis (RA) is an invalidating chronic autoimmune disorder characterized by joint inflammation and progressive bone damage. Dietary intervention is an important component in the treatment of RA to mitigate oxidative stress, a major pathogenic driver of the disease. Alongside traditional sources of antioxidants, microalgae—a diverse group of photosynthetic prokaryotes and eukaryotes—are emerging as anti-inflammatory and immunomodulatory food supplements. Several species accumulate therapeutic metabolites—mainly lipids and pigments—which interfere in the pro-inflammatory pathways involved in RA and other chronic inflammatory conditions. The advancement of the clinical uses of microalgae requires the continuous exploration of phytoplankton biodiversity and chemodiversity, followed by the domestication of wild strains into reliable producers of said metabolites. In addition, the tractability of microalgal genomes offers unprecedented possibilities to establish photosynthetic microbes as light-driven biofactories of heterologous immunotherapeutics. Here, we review the evidence-based anti-inflammatory mechanisms of microalgal metabolites and provide a detailed coverage of the genetic engineering strategies to enhance the yields of endogenous compounds and to develop innovative bioproducts.

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Section: Astaxanthin: the Red Gold Of Algaementioning

confidence: 99%

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

Cutolo,

Caferri,

Campitiello

et al. 2023

Marine Drugs

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Platycodon grandiflorus saponin alleviates MSU-induced gouty arthritis based on NLRP3/ASC/caspase-1 pathway

Sun

Liu

Zhang

et al. 2022

Preprint

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Platycodon grandiflorus is a homologous material of traditional medicine and food. Besides a pickle, more importantly, it can also be used in traditional Chinese medicine as an alternative to modern western. Various studies have found that saponins in Platycodon grandiflorus (PGS) can play a role in different diseases (including liver cancer, lung cancer, cardiovascular and cerebrovascular diseases) as the main chemical constituents. However, studies on the treatment of gout arthritis by PGS are not reported, and the mechanism has not been speculated and elucidated systematically. This study describes the anti-inflammatory agent of PGS in treating gouty arthritis by characterizing the degree of joint swelling, inflammatory factors (IL-6, IL-1β, TNF-α), peroxides (SOD, MDA, GSH-PX), histopathology and related proteins. The results show that when MSU is injected into the joint, it activates the NLRP3 protein to bind to caspase-1 via ASC to form the NLRP3 inflammatory conjugate, which undergoes a series of changes to promote the release of inflammatory factors causing joint swelling and pain. Therefore, the same as colchicine, PGS can effectively reduce the swelling degree, level of inflammatory factors, and related protein expression while diminishing oxidative stress levels. This study lays the foundation for treating gout arthritis by PGS.

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Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis

Pružinská,

Chrastina,

Khademnematolahi

et al. 2024

IJMS

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This in vivo study performed in rat adjuvant arthritis aims to advance the understanding of astaxanthin’s therapeutic properties for the possible treatment of rheumatoid arthritis (RA) in monotherapy and along with the standard RA treatment, methotrexate (MTX), in combination therapy. The main goal was to elucidate astaxanthin’s full therapeutic potential, evaluate its dose dependency, and compare its effects in monotherapy with other carotenoids such as β-carotene and β-cryptoxanthin (KXAN). Moreover, potential differences in therapeutic activity caused by using different sources of astaxanthin, synthetic (ASYN) versus isolated from Blakeslea trispora (ASTAP), were evaluated using one-way ANOVA (Tukey-Kramer post hoc test). KXAN was the most effective in reducing plasma MMP-9 levels in monotherapy, significantly better than MTX, and in reducing hind paw swelling. The differences in the action of ASTAP and ASYN have been observed across various biometric, anti-inflammatory, and antioxidative parameters. In combined therapy with MTX, the ASYN + MTX combination proved to be better. These findings, especially the significant anti-arthritic effect of KXAN and ASYN + MTX, could be the basis for further preclinical studies.

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Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers

Cited by 3 publications

References 27 publications

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

Platycodon grandiflorus saponin alleviates MSU-induced gouty arthritis based on NLRP3/ASC/caspase-1 pathway

Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis

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