Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells

Tripathi, Durga Nand; Jena, Gopabandhu

doi:10.1016/j.tox.2008.03.015

Cited by 125 publications

(99 citation statements)

References 64 publications

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“…CP is used in the treatment of various malignant and nonmalignant tumours [24]. It was chosen in the current study as it was previously shown to provide a suitable model for observing processes occurring in the seminiferous epithelium during impairment and restoration of spermatogenesis.…”

Section: Morphometric Resultsmentioning

confidence: 99%

Cadherin and vimentin immunoexpression in the testis of normal and induced infertility models of albino rats

2014

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Section: Morphometric Resultsmentioning

confidence: 99%

Cadherin and vimentin immunoexpression in the testis of normal and induced infertility models of albino rats

2014

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“…Meanwhile, antioxidant ability previously destroyed by CP was signifi cantly restored in mice administered with SIP. Increasing evidence to support the idea that the toxicity of CP can be weakened by some natural materials (5,6,8,9) including SIP, further indicates that these compounds are potential cytoprotectors that could be applied in clinical therapy for cancer.…”

Section: Discussionmentioning

confidence: 99%

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Le¹,

Luo²,

Gu³

et al. 2015

BLL

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Cyclophosphamide (CP) is a commonly used antitumour and immunosuppressive drug, but it is inevitable that the chemotherapeutic agent may cause long-term or permanent reproductive damage on young male patients through inducing oxidative stress in the testes. Squid ink polysaccharides (SIP), a newly found marine glycosaminoglycon have been proved to have antioxidant capabilities and chemotherapy-protective activities on model animals in our recent investigations. This study was conducted to assess whether or not SIP could protect male mice against gonadotoxicity during CP exposure. Sexually mature male Kunming mice were allocated to one of four groups. CP was abdominally administered at dose of 15 mg/kg body weight to two groups of mice for ten weeks, once a week, one group of mice received SIP at dose of 80 mg/kg body weight by gavage for ten weeks, once a day. The other two groups comprised a vehicle treated group and an SIP treated group. Toxicity of CP and protective activity of SIP on the testes were assessed by: sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sex hormone content, and histopathological features. Data showed CP-induced, serious negative changes on murine sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sexual hormone contents, and histopathological features which were all signifi cantly impaired by SIP. This study found that SIP were demonstrated to offer protective effects against CP-induced toxicity on testes in mice (Tab. 2, Fig. 3, Ref. 29). Text in PDF www.elis.sk.

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“…Astaxanthin has also been reported to protect against the toxic effects of some anticancer drugs. In a recent study, free astaxanthin showed chemoprotective potential in rats treated with cyclophosphamide 46 .…”

Section: Astaxanthin and Chronic Diseasesmentioning

confidence: 94%

Astaxanthin: structural and functional aspects

Seabra

Pedrosa

2010

Rev. Nutr.

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1 Article based on L.M.J. SEABRA' s thesis project entitled "Litopenaeus vannamei shrimp: components of nutritional importance in meat and processing waste. A B S T R A C TAstaxanthin, a carotenoid belonging to the xanthophyll class, has stirred great interest due to its antioxidant capacity and its possible role in reducing the risk of some diseases. Astaxanthin occurs naturally in microalgae, such as Haematococcus pluvialis and the yeast Phaffia rhodozyma, and has also been considered to be the major carotenoid in salmon and crustaceans. Shrimp processing waste, which is generally discarded, is also an important source of astaxanthin. The antioxidant activity of astaxanthin has been observed to modulate biological functions related to lipid peroxidation, having beneficial effects on chronic diseases such as cardiovascular disease, macular degeneration and cancer. Researches have shown that both astaxanthin obtained from natural sources and its synthetic counterpart produce satisfactory effects, but studies in humans are limited to natural sources. There is no established nutritional recommendation regarding astaxanthin daily intake but most studies reported beneficial results from a daily intake of 4mg. Thus, this review discusses some aspects of the carotenoid astaxanthin, highlighting its chemical structure and antioxidant activity, and some studies that report its use in humans.Indexing terms: Antioxidants. Astaxanthin. Carotenoids. Chronic diseases. R E S U M O

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Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells

Cited by 125 publications

References 64 publications

Cadherin and vimentin immunoexpression in the testis of normal and induced infertility models of albino rats

Cadherin and vimentin immunoexpression in the testis of normal and induced infertility models of albino rats

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Astaxanthin: structural and functional aspects

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