Astaxanthin effectiveness in preventing multiple sclerosis in animal model

Abstract

OBJECTIVE: The aim of the present study was to reveal the effect of therapeutic and prophylactic potential of astaxanthin in experimental autoimmune encephalomyelitis (EAE) as an acceptable model for the study of multiple sclerosis (MS). BACKGROUND: Astaxanthin has powerful antioxidant activities as well as several essential biological functions while multiple sclerosis prevention is highly regarded by researchers. METHODS: The astaxanthin potential in prevention of multiple sclerosis was examined in the chronic model of experimental autoimmune encephalomyelitis (EAE) by using female C57BL/6 mice induced with oligodendrocyte glycoprotein (MOG). Splenocytes were assessed to measure the levels of proinfl ammatory and antiinfl ammatory cytokines, proliferation rate and FoxP3+Treg cell frequency. Immunohistochemical examinations were performed on spinal cord and brain tissue. RESULTS: Astaxanthin reduced splenocytes proliferation index and proinfl ammatory cytokine levels, and vice versa increased the anti-infl ammatory cytokine levels. Immunohistochemical studies of the spinal cord and brain showed that the infi ltration with infl ammatory cells was highly confi ned in the central nervous system. Protective effects of astaxanthin were visible by assigning low score recording in clinical behavior and disease severity. CONCLUSION: Astaxanthin is a powerful tool for intervention in EAE on a model of multiple sclerosis, so it can be studied further to prevent and treat MS (Tab. 2, Fig. 3, Ref. 41). Text in PDF www.elis.sk.

Astaxanthin alleviates fine particulate matter (PM2.5)-induced lung injury in rats by suppressing ferroptosis and apoptosis

“…ASX is effective in preventing multiple sclerosis in animal models. 32 A recent review indicates that ASX can play a protective role in various diseases, including neurological diseases, diabetes, gastrointestinal diseases, liver and kidney diseases, eye and skin diseases, and bacterial infections, via anti-inflammatory effects. 33 ASX lung protection is increasingly achieved with the continuous development of research.…”

Astaksantinin Sinir Sistemi Üzerindeki Etkileri

“…Immunohistochemical examinations of the spinal cord and brain revealed that the inflammatory cell infiltration was restricted to the central nervous system. Astaxanthin's protective properties were also demonstrated by clinical behavior and illness severity (Bidaran et al, 2018).…”

Pengaruh <i>Astaxantine</i> Oral terhadap Kadar Serum <i>Tumor Necrosis Factor Alpha</i> pada Pasien Akne Vulgaris-lores

“…6 Sitokin ini akan disekresikan di lokasi infeksi atau jaringan yang cedera, memiliki banyak efek pada endotel pembuluh darah, leukosit dan sumsum tulang, kemudian akan meningkatkan pengiriman sel ke lokasi infeksi. 7 Reactive oxygen species (RoS) dapat menginduksi faktor transkripsi seperti nuclear factor kappa beta (NF-κβ) dan activator protein (AP)-1 yang berfungsi mengatur gen yang mengendalikan produksi kemokin, sitokin inflamasi dan molekul adhesi yang merangsang infiltrasi fagositosis. 8 Propionibacterium acnes menginduksi produksi RoS, mengaktivasi toll-like receptor-2, mitogen-activated protein kinase, NF-κβ dan ekspresi komponen inflammasome yang kemudian akan menginduksi sitokin proinflamasi.…”