Astaxanthin attenuates oxidative stress and immune impairment in <scp>d</scp>-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway

Chen, Zhiqing; Xiao, Jie; Liu, Han; Yao, Kangfei; Hou, Xiaoning; Cao, Yong; Liu, Xiaojuan

doi:10.1039/d0fo01663b

Cited by 35 publications

(20 citation statements)

References 62 publications

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“…As a consequence, the damage caused by oxidative stress to the liver and kidney could be largely attenuated. There is increasing evidence supporting the hypothesis that the crosstalk occurs between the NF-κBand Nrf2-related pathways [33,34]. NF-κB (p65) could interact with Keap1 to inhibit the activation of the Nrf2-ARE pathway [35], which was confirmed once again in our present study.…”

Section: Discussionsupporting

confidence: 88%

Vitamin D₃ Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Zhang

Liu

Fang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Vitamin D3, as an indispensable and fat-soluble micronutrient, plays an important role in the health of humans and animals. At present, studies are focusing on the calcium absorption and immunoregulation function of vitamin D3; this study was aimed at exploring the antioxidative stress ability of vitamin D3 on diquat-induced intestinal dysfunction of ICR mice and the underlying mechanism. The results showed that oral gavage of vitamin D3 daily significantly improved the body weight gain and immune organ index and significantly reverted the abnormal changes of ALT, AST, SOD, GSH-Px, T-AOC, and MDA in the serum and jejunum induced by diquat. The addition of vitamin D3 also significantly reduced the concentration of DAO, D-LA, and certain proinflammatory cytokines in serum. Moreover, vitamin D3 improved the pathological morphology of the duodenum, jejunum, colon, liver, and kidney tissues, and it also largely attenuated the degree of inflammatory infiltration of macrophages and cell apoptotic index of jejunal epithelial tissue induced by diquat. The results demonstrated that vitamin D3 significantly recovered the intestinal barrier injury by enhancing the expression of mucins and tight junction proteins in the jejunum. In addition, the results indicated that vitamin D3 could significantly reduce the phosphorylation level of NF-κB (p65) and enhance the expression of Nrf2 and HO-1 in the jejunum compared with the diquat-induced group. This study suggested that oral administration of vitamin D3 can protect mice against oxidative damage by inhibiting the phosphorylation level of NF-κB (p65) and activating Nrf2-related signaling pathways.

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Section: Discussionsupporting

confidence: 88%

Vitamin D₃ Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Zhang

Liu

Fang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Activated Nrf2 can modulate cellular antioxidant regulators; it can upregulate the expression of HO-1, SOD-1, and other downstream genes in normal cells to maintain the intracellular redox balance and reduce tumorigenesis ( 39 ). Activated Nrf2 is involved in the regulation of immune factors ( 40 , 41 ), which it achieves by inducing T lymphocytes to produce ILs, interferons, and TNF ( 42 ). In our previous experiments, we showed that Antrodia cinnamomea polysaccharides (APCS) enhance immune functions in mice by upregulating the expression of Nrf2 ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Wan-Nian-Qing, a Herbal Composite Prescription, Suppresses the Progression of Liver Cancer in Mice by Regulating Immune Response

et al. 2021

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The Wan-Nian-Qing prescription (WNQP), an herbal composite containing Ornithogalum caudatum, has been used in China for several years for cancer treatment. However, the mechanism of its pharmacological action against liver cancer is not clear. This study aimed to investigate the role of WNQP in inhibiting tumor growth in hepatocellular carcinoma model mice and determine its mechanism of action. We established HepG2- and SMMC-7721-xenografted tumor models in nude mice and BALB/c mice. The mice were administered WNQP for 2 weeks. The bodyweight of each mouse was monitored every day, and the tumor size was measured using vernier caliper before each round of WNQP administration. After the last dose, mice were sacrificed. The tumors were removed, lysed, and subjected to proteome profiling, enzyme-linked immunosorbent assay, and western blotting. The liver, spleen, and kidney were collected for histopathological examination. The effects of WNQP against liver cancer were first systematically confirmed in HepG2- and SMMC-7721-xenografted nude mice and BALB/c mice models. WNQP inhibited tumor growth, but failed to affect bodyweight and organ structures (liver and spleen), confirming that it was safe to use in mice. In BALB/c mice, WNQP regulated immune function, inferred from the modulation of immune-related cytokines such as interleukins, interferon, tumor necrosis factors, and chemokines. Further results confirmed that this regulation occurred via the regulatory effects of WNQP on Nrf2 signaling. WNQP can inhibit the growth of HepG2- and SMMC-7721-xenografted tumors in nude mice and BALB/c mice. This effect manifests at least partially through immunomodulation mediated apoptosis.

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“…In rats, astaxanthin significantly reduces pro-inflammatory mediators, including IL-1β, IL-6, NF-κB p65, and IβBa, and increases levels of IL-2, IgM, and IgG, suggesting that astaxanthin ameliorates oxidative stress and improves immune impairment ( Chen et al, 2020c ). Zhang and colleagues recently demonstrated that administration of astaxanthin (60 and 120 mg/kg/bw) in cyclophosphamide-induced immunodeficient mice effectively prohibited intestinal mucosa damage, by reducing oxidative stress levels, increasing intestinal morphological structural integrity, stimulating goblet cells growth and mucous secretion, decreasing development of Paneth cells and expression levels of antimicrobial peptides, increasing IgA secretion, and ameliorating main gut flora (especially total bacteria, Lactobacillus and Enterobacteriaceae spp.)…”

Section: Carotenoids Enhance Immunity Facing Covid-19 and Related Symptomsmentioning

confidence: 99%

Carotenoids: Therapeutic Strategy in the Battle against Viral Emerging Diseases, COVID-19: An Overview

Khalil

Tazeddinova

Aljoumaa

et al. 2021

Prev. Nutr. Food Sci.

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Carotenoids, a group of phytochemicals, are naturally found in the Plant kingdom, particularly in fruits, vegetables, and algae. There are more than 600 types of carotenoids, some of which are thought to prevent disease, mainly through their antioxidant properties. Carotenoids exhibit several biological and pharmaceutical benefits, such as anti-inflammatory, anti-cancer, and immunity booster properties, particularly as some carotenoids can be converted into vitamin A in the body. However, humans cannot synthesize carotenoids and need to obtain them from their diets or via supplementation. The emerging zoonotic virus severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19), originated in bats, and was transmitted to humans. COVID-19 continues to cause devastating international health problems worldwide. Therefore, natural preventive therapeutic strategies from bioactive compounds, such as carotenoids, should be appraised for strengthening physiological functions against emerging viruses. This review summarizes the most important carotenoids for human health and enhancing immunity, and their potential role in COVID-19 and its related symptoms. In conclusion, promising roles of carotenoids as treatments against emerging disease and related symptoms are highlighted, most of which have been heavily premeditated in studies conducted on several viral infections, including COVID-19. Further in vitro and in vivo research is required before carotenoids can be considered as potent drugs against such emerging diseases.

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Astaxanthin attenuates oxidative stress and immune impairment in d-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway

Abstract: As a potential antioxidant, astaxanthin (AST) exhibits anti-aging effects. However, its relationships to oxidative stress and immunity have yet to be sufficiently investigated. In this report, we performed integrated analysis...

Cited by 35 publications

References 62 publications

Vitamin D₃ Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Vitamin D₃ Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Wan-Nian-Qing, a Herbal Composite Prescription, Suppresses the Progression of Liver Cancer in Mice by Regulating Immune Response

Carotenoids: Therapeutic Strategy in the Battle against Viral Emerging Diseases, COVID-19: An Overview

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Astaxanthin attenuates oxidative stress and immune impairment in d-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway

Abstract: As a potential antioxidant, astaxanthin (AST) exhibits anti-aging effects. However, its relationships to oxidative stress and immunity have yet to be sufficiently investigated. In this report, we performed integrated analysis...

Cited by 35 publications

References 62 publications

Vitamin D3 Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Vitamin D3 Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Wan-Nian-Qing, a Herbal Composite Prescription, Suppresses the Progression of Liver Cancer in Mice by Regulating Immune Response

Carotenoids: Therapeutic Strategy in the Battle against Viral Emerging Diseases, COVID-19: An Overview

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Product

Resources

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Vitamin D₃ Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

Vitamin D₃ Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway