Astaxanthin attenuated thrombotic risk factors in type 2 diabetic patients

Chan, Kung‐Chi; Chen, Shih-Chueh; Chen, Pei-chi

doi:10.1016/j.jff.2018.12.012

Cited by 41 publications

(27 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chan et al showed that, in diabetic rats, dietary intake of astaxanthin (at 0.01 and 0.05%) exhibited anti-inflammatory and anti-coagulatory effect [85]. Moreover, a clinical trial in T2DM patients (daily intake up to 12 mg ASX) significantly attenuated hemostatic disorders and reduced the inflammatory cytokines level without affecting renal function [119]. Further investigations are needed to clarify the mechanisms and the effects of ASX in the DM context.…”

Section: Cardiovascular Protective Effect Of Astaxanthin In Diabetesmentioning

confidence: 99%

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

et al. 2020

View full text Add to dashboard Cite

Oxidative stress (OS) plays a pivotal role in diabetes mellitus (DM) onset, progression, and chronic complications. Hyperglycemia-induced reactive oxygen species (ROS) have been shown to reduce insulin secretion from pancreatic β-cells, to impair insulin sensitivity and signaling in insulin-responsive tissues, and to alter endothelial cells function in both type 1 and type 2 DM. As a powerful antioxidant without side effects, astaxanthin (ASX), a xanthophyll carotenoid, has been suggested to contribute to the prevention and treatment of DM-associated pathologies. ASX reduces inflammation, OS, and apoptosis by regulating different OS pathways though the exact mechanism remains elusive. Based on several studies conducted on type 1 and type 2 DM animal models, orally or parenterally administrated ASX improves insulin resistance and insulin secretion; reduces hyperglycemia; and exerts protective effects against retinopathy, nephropathy, and neuropathy. However, more experimental support is needed to define conditions for its use. Moreover, its efficacy in diabetic patients is poorly explored. In the present review, we aimed to identify the up-to-date biological effects and underlying mechanisms of ASX on the ROS-induced DM-associated metabolic disorders and subsequent complications. The development of an in-depth research to better understand the biological mechanisms involved and to identify the most effective ASX dosage and route of administration is deemed necessary.

show abstract

Section: Cardiovascular Protective Effect Of Astaxanthin In Diabetesmentioning

confidence: 99%

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…AST is one of the most powerful carotenoids with antioxidant and anti‐inflammatory effects activity 15 . It has previously been indicated that AST reduces the levels of activated macrophages (MCP‐1) and the pro‐inflammatory cytokines (IL‐6 and TNF‐α) 15,19 . The anti‐inflammatory role mediated via inhibiting NF‐κB activation in diabetes‐induced models has also been shown 20 .…”

Section: Discussionmentioning

confidence: 99%

“…15 It has previously been indicated that AST reduces the levels of activated macrophages (MCP-1) and the pro-inflammatory cytokines (IL-6 and TNF-α). 15,19 The anti-inflammatory role mediated via inhibiting NF-κB activation in diabetes-induced models has also been shown. 20 I addition, it seems that AST improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the antioxidant defence system's activity.…”

Section: Discussionmentioning

confidence: 99%

The antioxidant and anti‐inflammatory effects of astaxanthin supplementation on the expression of miR‐146a and miR‐126 in patients with type 2 diabetes mellitus: A randomised, double‐blind, placebo‐controlled clinical trial

Mashhadi

Tahmasebi

Mohammadi-Asl

et al. 2021

Int. J. Clin. Pract.

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM), is recognised by hyperglycaemia resulting from tissue insulin resistance and insufficient insulin secretion. 1 T2DM is a complicated condition that is mostly associated with increased inflammatory markers and adipokines, including neuregulin and omentin, and impaired erythrocyte distribution. [2][3][4] Hyperglycaemia stimulates chronic inflammation marker secretion and contributes to increased ROS levels, consequently decreasing insulin secretion and insulin sensitivity and ultimately contributing to T2DM-related complications. 5,6 The microRNAs (miRNAs), small non-coding ribonucleic acids (RNAs), modulate gene expression levels through their interaction with the 3′UTR of the genes which eventually lead to RNA

show abstract

“…Ingestion of daily ASX supplementation significantly reduced tumor necrosis factor-α (TNF-α) and plasma IL-6 levels and further decrease in HbA1c (%) and blood glucose levels. Specifically, a higher dosage supplementation significantly reduced the levels of LDL, total cholesterol, plasma TG, and clotting factors such as factor VII and plasminogen activator inhibitor [27]. Data from ten RCTs of the recent meta-analysis found that fasting blood glucose levels were significantly decreased by ASX supplementation [28].…”

Section: Diabetesmentioning

confidence: 99%

Astaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive review

Medhi¹,

Kalita²

2021

J App Biol Biotech

View full text Add to dashboard Cite

Astaxanthin (ASX) is a xanthophyll carotenoid, naturally synthesized by Algae, Yeast, and bacteria. They are not just a powerhouse of antioxidant properties but also possess anti-inflammatory and other bioactive properties. Haematococcus pluvialis is the potential ASX source and shows powerful regulation on many health diseases. Over the decades, numerous studies have emphasized its importance in many human health diseases such as neurodegenerative disorders, cardiovascular diseases, Alzheimer, Parkinson, skin allergies, COVID-19, and many more. The present review discusses available evidence on the functional activities of ASX in various diseases and summarizes the potential factors involved in ASX response and highlights the potential implications.

show abstract

Astaxanthin attenuated thrombotic risk factors in type 2 diabetic patients

Cited by 41 publications

References 40 publications

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

The antioxidant and anti‐inflammatory effects of astaxanthin supplementation on the expression of miR‐146a and miR‐126 in patients with type 2 diabetes mellitus: A randomised, double‐blind, placebo‐controlled clinical trial

Astaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive review

Contact Info

Product

Resources

About