Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.

Abstract

Abstract:Five new shionane-type triterpenes, astataricusones A-D (compounds 1-4) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC 50 value of 23.5 μM, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC 50 values of 18.6 and 40.5 μM, and cytotoxicity on HepG 2.2.15 cells with CC 50 values of 172.4 and 137.7 μM, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC 50 values of 2.7 and 30.7 μM, respectively.

New Triterpenoids from the Stems of <i>Cornus walteri</i>

“…2). The hydroxyl group of C-20 was confirmed to be α-oriented based on the NOESY correlations of H-17/H 3 -21 and H 3 -18/H 3 -21 19) (Fig. 3).…”

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

“…The roots and rhizomes of Aster tataricus L. f. (Compositae), recorded as ingredients of traditional Chinese medicine (TCM) in all editions of the Chinese pharmacopeia, have been used to relieve cough and eliminate phlegm for more than 2,000 years in China. We successfully isolated about 80 compounds via phytochemical investigation of A. tataricus, which mainly include peptides, triterpenoids, flavonoids, and sterols (Xu et al, 2013a(Xu et al, , 2013bZhou et al, 2010Zhou et al, , 2013Zhou et al, , 2014. Notably, we isolated 14 chlorinated cyclopentapeptides (astins A-H and K-P, belonging to Compositae-type cyclopeptides), which are unique components of A. tataricus (Xu et al, 2013b).…”

Cyanodermella asteris sp. nov. (Ostropales) from the inflorescence axis of Aster tataricus

“…Its roots are well known in traditional Chinese and Japanese medicine due to their diuretic, antibacterial, antiviral, and anti-ulcer activities (Shao et al 1997a, b;Shirota et al 1997). Diverse secondary metabolites have been identified in A. tataricus roots: shiononetype triterpenes [e.g., astataricusones and astataricusol (Zhou et al 2013); astershionones (Zhou et al 2014)], cyclopeptides[e.g., astins (Morita et al 1996)], and flavonoids [e.g., quercetin and kaempferol (Wang et al 2003)].…”