AST/ALT ratio predicts the functional severity of chronic heart failure with reduced left ventricular ejection fraction

Abstract

Objective: Despite previous research that focused on liver transaminases as predictors of cardiovascular disease, there has been limited research evaluating the predictive value of AST/ALT ratio in patients with heart failure. We aimed to investigate AST/ALT ratio as an indicator of the functional severity in chronic heart failure with reduced left ventricular ejection fraction. Results:Overall, 105 patients previously diagnosed with HFrEF from Buraidah-Al Qassim province, Saudi Arabia were included in this retrospective cross-sectional study. Data on study variables, including demographic data, left ventricular ejection fraction, NYHA class, and AST/ALT ratio, were collected from patients' records. The patients were divided into two groups, namely group-1 (AST/ALT ratio < 1) and group-2 (AST/ALT ratio ≥ 1), to identify any differences in their cardiac function profiles. NYHA class and NT-proBNP were higher and LVEF was lower in group-2 than in group-1. We found a mild significant correlation between AST/ALT ratio and APRI, FIB-4 score, NYHA-class, and LVEF (r = 0.2, 0.25, 0.26, and − 0.24, respectively; P < 0.05). Multivariate linear regression analysis model and ROC curve showed that AST/ALT ratio could independently predict HFrEF functional severity with a best cut-off value of 0.9, sensitivity of 43.6%, and specificity of 81.4%.

Association Between AST to ALT Ratio and Peripheral Artery Disease in Chinese Hypertensive Population: A Cross-Sectional Study

“…Presious studies have shown that AST/ALT was associated with cardiovascular disease. For instance, Mohammed Ewid et alconducted a study which evaluated the functional severity of chronic heart failure with reduced left ventricular ejection(HFrEF) , found that 0.9 was the best predictive cut-off value of the AST / ALT ratio [16] . At the same time,a study demonstrated that the best cut-off value in predicting the cardiometabolic risk in the AST / ALT ratio was 1 [17] .…”

Association between AST to ALT ratio and peripheral artery disease in Chinese adults with hypertension：a cross-sectional study

“…Previous studies have shown that AST/ALT ratio was associated with cardiovascular disease. For instance, Mohammed Ewid et alconducted a study which evaluated the association between AST/ALT ratio and functional severity of chronic heart failure with reduced left ventricular ejection (HFREF), suggested that AST/ALT ratio of 0.9 was the best cut-off value to forecast left ventricular function status [15] . At the same time, a study demonstrated that the best cut-off value of the AST / ALT ratio in predicting the cardiometabolism risk in was 1 [16] .…”

Association Between AST To ALT Ratio And Peripheral Artery Disease In Chinese Adults With Hypertension: A Cross-Sectional Study

“…For instance, Mohammed Ewid et alconducted a study which evaluated the association between AST/ALT ratio and functional severity of chronic heart failure with reduced left ventricular ejection (HFREF) , suggested that AST/ALT ratio of 0.9 was the best cut-off value to forecast left ventricular function status [21] . At the same time, a study demonstrated that the best cut-off value of the AST / ALT ratio in predicting the cardiometabolism risk in was 1 [21,22] . In addition Gao F et al analyzed the relationship between AST / ALT ratio and poor outcomes prognosis in patients with acute ischemic stroke [23] .…”