Assumed oxygen consumption based on calculation from dye dilution cardiac output: an improved formula

Bergstra, A; Dijk, Rene B. van; Hillege, H. L.; Lie, K. I.; Mook, G. A.

doi:10.1093/oxfordjournals.eurheartj.a060976

Cited by 53 publications

(69 citation statements)

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“…12 More recently published estimating formulae presently in broader clinical use, such as that by LaFarge and colleagues, 6 were derived primarily from pediatric patients. Similarly, many of the patients used to derive the Bergstra formula 8 were infants and children with congenital heart disease, possibly confounding the application of these methods in adult patients. Previous studies have demonstrated errors in VȮ 2 estimation using these and other formulae in pediatric [19][20][21][22] and adult [23][24][25] populations.…”

Section: Discussionmentioning

confidence: 99%

“…For sensitivity analysis, estimation of VȮ 2 was also calculated using the formula of LaFarge 6 : VȮ 2 (ml/min) = 138.1 -(X × log e age) + (0.378 × Heart Rate) × BSA (Men: X = 11.49; Women: X = 17.04); and the formula of Bergstra 8 : VȮ 2 (ml/min) = 157.3 × BSA + X -(10.5 × log e age) + 4.8 (Men: X = 10; Women = 0).…”

Section: Calculating Estimated Vȯmentioning

confidence: 99%

“…As a result, resting VȮ 2 is commonly estimated rather than measured using derived formulae available in the peer-reviewed literature. [6][7][8][9] However, the accuracy of the formulae and nomograms most commonly used to estimate resting VȮ 2 is questionable, with most estimating methods derived from limited samples of highly selected, ethnically homogenous populations consisting of similarly aged, lean adults, [10][11][12] populations that differ substantially from contemporary adult cardiology practice. Other formulae were derived from clinical populations composed exclusively or primarily of infants and children.…”

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confidence: 99%

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Inaccuracy of Estimated Resting Oxygen Uptake in the Clinical Setting

Narang

Thibodeau²,

Levine

et al. 2014

Circulation

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Hence, we assessed the accuracy of estimated resting VȮ 2 compared with measured VȮ 2 obtained by the gold-standard analysis of timed collections of exhaled air by the method of Douglas in a large population of consecutive adult patients who underwent right-heart cardiac catheterization for clinical indications at our hospital. Clinical Perspective on p 210Background-The Fick principle (cardiac output = oxygen uptake (VȮ 2 )/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured VȮ 2 is commonly used because of complexities of the measurement, though the accuracy of estimation remains uncertain in contemporary clinical practice. Methods and Results-From 1996 to 2005, resting VȮ 2 was measured via the Douglas bag technique in adult patients undergoing right heart catheterization. Resting VȮ 2 was estimated by each of 3 published formulae. Agreement between measured and estimated VȮ 2 was assessed overall, and across strata of body mass index, sex, and age. The study included 535 patients, with mean age 55 yrs, mean body mass index 28.4 kg/m 2 ; 53% women; 64% non-white. Mean (±standard deviation) measured VȮ 2 was 241 ± 57 ml/min. Measured VȮ 2 differed significantly from values derived from all 3 formulae, with median (interquartile range) absolute differences of 28.4 (13.1, 50.2) ml/min, 37.7 (19.4, 63.3) ml/min, and 31.7 (14.4, 54.5) ml/min, for the formulae of Dehmer, LaFarge, and Bergstra, respectively (P<0.0001 for each). The measured and estimated values differed by >25% in 17% to 25% of patients depending on the formula used. Median absolute differences were greater in severely obese patients (body mass index > 40 kg/m 2 ), but were not affected by sex or age. Conclusions-Estimates

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Section: Discussionmentioning

confidence: 99%

Section: Calculating Estimated Vȯmentioning

confidence: 99%

mentioning

confidence: 99%

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Inaccuracy of Estimated Resting Oxygen Uptake in the Clinical Setting

Narang

Thibodeau²,

Levine

et al. 2014

Circulation

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“…Mean right atrial pressure and mean, systolic and diastolic aortic pressures were obtained from an external transducer (Gould P23 XL). Cardiac output was calculated continuously according to Fick, using an assumed oxygen consumption [29], the mixed venous oxygen saturation measured in the pulmonary artery, the arterial oxygen saturation measured by a pulse oximeter (Datex), and the hemoglobin concentration measured from an arterial blood sample. Systemic vascular resistance was calculated from cardiac output and mean aortic and right atrial pressures.…”

Section: Measurementsmentioning

confidence: 99%

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Bergstra

Dijk

Brekke³

et al. 2000

Cathet. Cardiovasc. Intervent.

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A crossover study was performed to compare the hemodynamic effects of the iso-osmolar contrast agent iodixanol (Visipaque) 320 mg I/ml to those of the low-osmolar iohexol (Omnipaque) 350 mg I/ml. The main hypothesis was that iodixanol and iohexol would affect left ventricular end-diastolic pressure (LVEDP) to different degrees. In 48 patients with reduced cardiac function (mean ejection fraction 33. 4%), one ventricular injection was performed with each contrast medium. Ventricular, aortic and right atrial pressures and heart rate were measured continuously. Cardiac output (using Fick's principle) and systemic vascular resistance were calculated. LVEDP increased with both agents, but significantly less after iodixanol than after iohexol (P < 0.01), also in subgroups of patients in whom baseline LVEDP was severely increased and in whom 3-vessel disease was present. Immediate changes in variables reflecting vasodilatation were similar with both agents. In conclusion, both contrast agents influenced hemodynamics during ventriculography, but iodixanol had significantly less influence on LVEDP than did iohexol.

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“…Indirect Fick principle as well as thermodilution method were used to calculate CO, CI and pulmonary vascular resistance (PVR). Oxygen consumption was assumed from equation suggested by Bergstra [6].…”

Section: Methodsmentioning

confidence: 99%

The pilot study of role of electrical cardiometry in non-invasive assessment of hemodynamic parameters in patients with pulmonary arterial hypertension (RCD code: II-1A.1)

Kazimierczyk

Jasiewicz

Marcinkiewicz-Siemion

et al. 2017

Journal of Rare Cardiovascular Diseases

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Background: Electrical cardiometry (EC) technique could estimate cardiac output (CO), cardiac index (CI) and other parameters related to cardiac contractility and fluid status by measuring the thoracic electrical bioimpedance. We hypothesized that EC could assess right ventricle (RV) hemodynamic function in patients diagnosed with pulmonary arterial hypertension (PAH). Results: In our pilot study, enrolling 23 PAH patients, we observed a significant correlation (r = 0.71; p <0.001) between thermodilution CO measurement results (4.59 ±1.05 l/min) and CO results obtained by EC (4.86 ±1.20 l/min) and between systemic vascular resistance calculated by EC monitor and obtained during right heart catheterization (RHC) (r = 0.68; p = 0.002). Furthermore, EC parameter index of contractility (ICON) significantly correlated with tricuspid annular plane systolic excursion assessed by echocardiography (r = 0.57; p = 0.01). Conclusions: RHC cannot be replaced in obtaining accurate results of CO, however EC technique provides feasible insight into RV function at the bedside or outpatient care. JRCD 2017; 3 (2): 44-49

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Assumed oxygen consumption based on calculation from dye dilution cardiac output: an improved formula

Cited by 53 publications

References 0 publications

Inaccuracy of Estimated Resting Oxygen Uptake in the Clinical Setting

Inaccuracy of Estimated Resting Oxygen Uptake in the Clinical Setting

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

The pilot study of role of electrical cardiometry in non-invasive assessment of hemodynamic parameters in patients with pulmonary arterial hypertension (RCD code: II-1A.1)

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