Associative processes in adaptation to repeated cold exposure in rats.

There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance. On the basis of a conditioning analysis of tolerance, we would expect that it should be possible to establish drug-paired cues as occasion setters, as well as conditional stimuli. Using feature-positive discrimination training, we evaluated the contribution of occasion-setting stimuli (as well as CSs) to tolerance to the hypothermic effect of ethanol in rats. The results indicated that a complete associative analysis of drug tolerance should incorporate not only the CS properties of predrug cues, but also the occasion-setting properties of such cues. The findings have implications for interpreting conflicting findings concerning extinction of tolerance and for cue-exposure treatments of addiction.

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Occasion setting and drug tolerance

Ramos

Siegel

Bueno

2002

Integrative Physiological & Behavioral Science

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Siegel

Linders

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Blustein

Hornig

Bostwick-Poli

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Associative processes in adaptation to repeated cold exposure in rats.

Cited by 15 publications

References 18 publications

Occasion setting and drug tolerance

Occasion setting and drug tolerance

Cue-contingent adaptation to color

Role of contextual stimuli in tolerance to stress-induced analgesia

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