Associative learning contributes to the increased water intake observed after daily injections of angiotensin II

Postolache, Maggie; Santollo, Jessica; Daniels, Derek

doi:10.1016/j.physbeh.2017.07.005

Cited by 3 publications

(1 citation statement)

References 32 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings parallel studies on AgRP neurons of the arcuate nucleus and their responses to food and food restriction [as described above, ( 66 )]. Interestingly, effects of the thirst-promoting hormone, angiotensin II, may, in part, require learned associations between angiotensin II receptor signaling and subsequent water intake ( 122 ). These data suggest that the central control of thirst is not limited to basic homeostatic responses and involves complex interactions between physiological state and forebrain processes that allow for the approach, consumption and reinforcement of water in order to restore body fluid homeostasis.…”

Section: Physiological and Neural Control Of Homeostasismentioning

confidence: 99%

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

2018

View full text Add to dashboard Cite

Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumption, in turn, reinforces motivated behavior and is therefore considered rewarding. Over the years, the constructs of homeostatic (within the purview of the hypothalamus) and reward (within the purview of mesolimbic circuitry) have been used to describe need-based vs. need-free consumption. However, many experiments have demonstrated that mesolimbic circuits and “higher-order” brain regions are also profoundly influenced by changes to physiological state, which in turn generate behaviors that are poised to maintain homeostasis. Mesolimbic pathways, particularly dopamine neurons of the ventral tegmental area (VTA) and their projections to nucleus accumbens (NAc), can be robustly modulated by a variety of energy balance signals, including post-ingestive feedback relaying nutrient content and hormonal signals reflecting hunger and satiety. Moreover, physiological states can also impact VTA-NAc responses to non-nutritive rewards, such as drugs of abuse. Coupled with recent evidence showing hypothalamic structures are modulated in anticipation of replenished need, classic boundaries between circuits that convey perturbations in homeostasis and those that drive motivated behavior are being questioned. In the current review, we examine data that have revealed the importance of mesolimbic dopamine neurons and their downstream pathways as a dynamic neurobiological mechanism that provides an interface between physiological state, perturbations to homeostasis, and reward-seeking behaviors.

show abstract

Section: Physiological and Neural Control Of Homeostasismentioning

confidence: 99%