Associations with meibomian gland loss in soft and rigid contact lens wearers

Harbiyeli, İbrahim İnan; Bozkurt, Banu; Erdem, Elif; Ozcan, Hamide Gizem; Çam, Burcu; Sertdemır, Yaşar; Yaǵmur, Meltem

doi:10.1016/j.clae.2020.12.005

Cited by 13 publications

(36 citation statements)

References 21 publications

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“…It is generally accepted that the duration of contact lens plays a more critical role on the meibomian gland, rather than lens material (47). If anything, however, OOK lens materials have higher oxygen permeability and induce less hypoxia and inflammation (48)(49)(50). In addition, the MGD was also considered to be posterior blepharitis involving various inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Yuan

et al. 2022

Front. Med.

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PurposePrevious studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.MethodsThirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.ResultsThe OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids (p < 0.05) but not in the upper eyelids. Within the OOK group, LLT was significantly impacted by the partial blink rate (p < 0.05) and the total score of the upper meibomian gland (p = 0.10).ConclusionsWearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.

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Section: Discussionmentioning

confidence: 99%

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Yuan

et al. 2022

Front. Med.

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“…Participants with ocular surface complications in the last 6 months were excluded from the study [ 9 ]. CL wearers were instructed to remove their CLs the night before the study and to attend the visit without wearing them [ 6 , 9 ]. Only the right eye of each participant was assessed to avoid data bias [ 6 , 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…Thus, dryness, discomfort, tearing, itching, hyperaemia and/or blurred vision are common signs and symptoms in CL wearers [ 4 , 5 ]. Consequently, dryness and lens discomfort could cause CL discontinuation and a reduction in the quality of life of CL wearers [ 3 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility

García‐Marqués

Talens‐Estarelles

García‐Lázaro

et al. 2022

Life

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As contact lens (CL) wear affects the ocular surface, this cross-sectional study aims to assess the effects of soft CL wear and its duration on the tear film and meibomian gland (MG) drop-out and visibility. Thirty non-CL wearers (22.5 ± 2.3 years) and twenty-four soft CL wearers (23.8 ± 2.2 years) participated in this study. The Keratograph 5M was used to assess the ocular surface. CL users were surveyed on years of CL wear and hours per week. MG visibility was assessed using a previously developed method based on analysing pixel intensity of meibographies. The CL group showed higher gland drop-out (p < 0.001) and lower gland visibility (p < 0.022). Gland drop-out was independently associated with CL wear (p = 0.006). When gland drop-out was excluded, the relative energy of pixel intensity values showed an independent association with CL wear (p = 0.005). Prolonged hours of CL wear were associated with higher dry eye symptoms and entropy of MGs (p < 0.029). A reduction in non-invasive keratograph break-up time was associated with using CLs for ≥8 years (p = 0.030). Overall, gland drop-out was higher and gland visibility lower in soft CL wearers. New gland visibility metrics might help to assess MGs in soft CL wearers quickly and objectively.

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“…Wearing a contact lens was the independent risk factor of the development of MGD, especially in rigid contact lens using 25 . And it could also be argued to have potential adverse effects towards the development of depression.…”

Section: Discussionmentioning

confidence: 98%

A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms

Wei

Liang

Cao

et al. 2022

Sci Rep

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Increased prevalence of depression has been found in patients with meibomian gland dysfunction (MGD); however, specific conditions of patients suffered from MGD and depression remains unclear. Our aim was to investigate the prevalence of depression in patients with MGD and analyze the risk factors of depression in MGD patients. In this multi-center cross-sectional study, we enrolled 830 MGD patients and 114 normal controls. Demographic information was collected by designed questionnaires about lifestyle habits, systemic and ocular medical history. Ophthalmic examinations were performed in a formal order. Depression symptoms were evaluated with a questionnaire survey using a modified self-rating depression scale (M-SDS). The correlations between the M-SDS score and demographic and clinical information were analyzed. The prevalence of hyperlipidemia and obstructive sleep apnea–hypopnea syndrome (OSAHS) was higher in the MGD group. There were 78 cases (9.4%) with depressive symptoms in the MGD group whereas there were 4 cases (3.5%) in controls. Similarly, M-SDS was higher in the MGD group. The characteristics of depression in the MGD group included: crying spells, sleep disturbance and depressed appetite. Some systemic diseases (OSAHS, allergy, skin disease) and the use of contact lenses was correlated with an increased risk of depressive symptoms in MGD patients.

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Associations with meibomian gland loss in soft and rigid contact lens wearers

Cited by 13 publications

References 21 publications

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility

A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms

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