Associations of β-Fibrinogen Polymorphisms with the Risk of Ischemic Stroke: A Meta-analysis

Luo, Hailong; Li, Xin; Jiang, Aiying; Zhang, Benzhuo; Bi, Pengxiang; Dong, Yan; Guo, Yanqin

doi:10.1016/j.jstrokecerebrovasdis.2018.09.007

Cited by 17 publications

(7 citation statements)

References 17 publications

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“…Levels of fibrinogen were correlated with CRP after adjustment for potential confounders, which has also been demonstrated in our previous studies ( 8 ). Furthermore, elevated circulating fibrinogen levels are associated with an increased risk of cardiovascular disease, such as coronary heart disease and stroke ( 18 , 19 ). Fibrinogen levels also predict the incidence of DVT ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture

Liu

et al. 2022

Front. Cardiovasc. Med.

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Diabetes mellitus is associated with prothrombotic states and thrombotic events. This study examined the association between preoperative glucose levels and deep vein thrombosis (DVT) in trauma patients undergoing surgery for lower limb fracture. Data from 1,591 patients who underwent fracture surgery between January 2017 and March 2022 at the Affiliated Hospital of Qingdao University were queried from institutional electronic medical records. A total study population of 1,086 patients was identified, comprising 138 patients who experienced DVT and 948 controls. The primary outcome was DVT. Multiple logistic regression analyses were performed and a receiver operating characteristic (ROC) curve was generated. Age, D-dimer level, preoperative RBC count, and preoperative glucose level were independent predictors of DVT. The two highest categories of D-dimer level (≥ 960, < 2,102; ≥ 2,102 ng/ml) increased the odds ratio for DVT by 4.215 times [95% confidence interval (CI) 1.820–9.761] and 7.896 times (95% CI 3.449–18.074), respectively, compared with the lowest reference category (< 490 ng/ml). The area under the curve (AUC) for the preoperative glucose level was 0.605. Hyperglycemia (glucose ≥ 6.1, < 7.0 mmol/l) increased the odds of DVT by 1.889-fold [95% CI (1.085–3.291); p < 0.0001] compared with euglycemia (glucose < 6.1 mmol/l). We therefore observed an association between preoperative hyperglycemia and DVT in patients with lower limb fractures. There are several modalities for controlling hyperglycemia, offering potential targets for future improvement.

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Section: Discussionmentioning

confidence: 99%

Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture

Liu

et al. 2022

Front. Cardiovasc. Med.

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“…The -148 C/T polymorphism was significantly correlated with the risk of ischemic stroke in both Asians and Caucasians, while the -455 G/A polymorphism was only significantly correlated with the risk of ischemic stroke in Asians. Moreover, it was found that both FGB -148 C/T and -455 G/A polymorphisms were significantly correlated with the risk of cerebral infarction [ 85 ]. In a study by Canseco-Avila et al, covering 118 subjects with unstable and stable CAD, it was shown that fibrinogen plasma concentrations (>465 mg/dL) were significant in patients with CAD.…”

Section: Fibrinogen Molecular Modifications and Cardiovascular Riskmentioning

confidence: 99%

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

Surma

Banach

2021

IJMS

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Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease, cerebrovascular disease, and peripheral arterial disease, represent a significant cause of premature death worldwide. Biomarkers, the evaluation of which would allow the detection of ASCVD at the earliest stage of development, are intensively sought. Moreover, from a clinical point of view, a valuable biomarker should also enable the assessment of the patient’s prognosis. It has been known for many years that the concentration of fibrinogen in plasma increases, inter alia, in patients with ASCVD. On the one hand, an increased plasma fibrinogen concentration may be the cause of the development of atherosclerotic lesions (increased risk of atherothrombosis); on the other hand, it may be a biomarker of ASCVD, as it is an acute phase protein. In addition, a number of genetic polymorphisms and post-translational modifications of fibrinogen were demonstrated that may contribute to the risk of ASCVD. This review summarizes the current data on the importance of fibrinogen as a biomarker of ASCVD, and also presents the relationship between molecular modifications of this protein in the context of ASCVD.

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“…The beta-fibrinogen -455G>A variant has been found with a higher frequency among patients with IS and acute myocardial infarction and it has been considered as a risk factor for IS among Asians [ 22 ]. In this way, our data are in agreement and could give the suggestion to routinely test plasma levels of fibrinogen in patients with IS [ 23 ] as far as the follow up for the secondary stroke prevention.…”

Section: Discussionmentioning

confidence: 99%

Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack

et al. 2021

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Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention.

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Associations of β-Fibrinogen Polymorphisms with the Risk of Ischemic Stroke: A Meta-analysis

Cited by 17 publications

References 17 publications

Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture

Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack

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