Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis

Román, Cristina A F; Wylie, Glenn R.; DeLuca, John; Yao, Bing

doi:10.3389/fneur.2022.911012

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…To investigate the stability of the rate of increase in CF across the four runs of the two tasks, a regression line was t to the ve VAS-F scores for each task and participant 51 . The slope of this regression line was operationalized as the CF rate (CFR) and the correlation of the CFR across tasks was calculated with a Pearson's correlation.…”

Section: Rate Of Cf Increase and Stability Of Cf Across Taskmentioning

confidence: 99%

Determinants of cognitive fatigue: Evaluating the effects of brain injury, disease and tasks

Wylie

Genova

Yao

et al. 2023

Preprint

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Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, and cerebral activation within and across populations by combining the data from two cross-sectional studies. Individuals with multiple sclerosis (MS) were included to model CF resulting from neurological disease; individuals who had sustained a traumatic brain injury (TBI) were included to model CF resulting from neurological insult; both groups were compared with a control group (Controls). CF was induced while neuroimaging data was acquired using two different tasks. CF significantly differed between the groups, with the clinical groups reporting more CF than Controls. The accrual of CF did not differ across the three groups; and CF ratings were consistent across tasks. Increasing CF was associated with longer response time for all groups. The brain activation in the caudate nucleus and the thalamus was consistently correlated with CF in all three groups, while more dorsally in the caudate, activation differed across the groups. These results suggest the caudate and thalamus to be central to CF while more dorsal aspects of the caudate may be sensitive to damage associated with particular types of insult.

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Section: Rate Of Cf Increase and Stability Of Cf Across Taskmentioning

confidence: 99%

Determinants of cognitive fatigue: Evaluating the effects of brain injury, disease and tasks

Wylie

Genova

Yao

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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Structural neural correlates of mental fatigue and reward-induced improvement in performance

Matuz,

Darnai,

Zsidó

et al. 2023

BIOLOGIA FUTURA

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Neuroimaging studies investigating the association between mental fatigue (henceforth fatigue) and brain physiology have identified many brain regions that may underly the cognitive changes induced by fatigue. These studies focused on the functional changes and functional connectivity of the brain relating to fatigue. The structural correlates of fatigue, however, have received little attention. To fill this gap, this study explored the associations of fatigue with cortical thickness of frontal and parietal regions. In addition, we aimed to explore the associations between reward-induced improvement in performance and neuroanatomical markers in fatigued individuals. Thirty-nine healthy volunteers performed the psychomotor vigilance task for 15 min (i.e., 3 time-on-task blocks of 5 min) out of scanner; followed by an additional rewarded block of the task lasting 5 min. Baseline high-resolution T1-weigthed MR images were obtained. Reaction time increased with time-on-task but got faster again in the rewarded block. Participants’ subjective fatigue increased during task performance. In addition, we found that higher increase in subjective mental fatigue was associated with the cortical thickness of the following areas: bilateral precuneus, right precentral gyrus; right pars triangularis and left superior frontal gyrus. Our results suggest that individual differences in subjective mental fatigue may be explained by differences in the degree of cortical thickness of areas that are associated with motor processes, executive functions, intrinsic alertness and are parts of the default mode network.

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Evaluating the effects of brain injury, disease and tasks on cognitive fatigue

Wylie,

Genova,

Yao

et al. 2023

Sci Rep

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Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, and cerebral activation within and across populations by combining the data from two cross-sectional studies. Individuals with multiple sclerosis (MS) were included to model CF resulting from neurological disease; individuals who had sustained a traumatic brain injury (TBI) were included to model CF resulting from neurological insult; both groups were compared with a control group (Controls). CF was induced while neuroimaging data was acquired using two different tasks. CF significantly differed between the groups, with the clinical groups reporting more CF than Controls—a difference that was statistically significant for the TBI group and trended towards significance for the MS group. The accrual of CF did not differ across the three groups; and CF ratings were consistent across tasks. Increasing CF was associated with longer response time for all groups. The brain activation in the caudate nucleus and the thalamus was consistently correlated with CF in all three groups, while more dorsally in the caudate, activation differed across the groups. These results suggest the caudate and thalamus to be central to CF while more dorsal aspects of the caudate may be sensitive to damage associated with particular types of insult.

show abstract

Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis

Cited by 3 publications

References 76 publications

Determinants of cognitive fatigue: Evaluating the effects of brain injury, disease and tasks

Determinants of cognitive fatigue: Evaluating the effects of brain injury, disease and tasks

Structural neural correlates of mental fatigue and reward-induced improvement in performance

Evaluating the effects of brain injury, disease and tasks on cognitive fatigue

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