Associations of waking cortisol with DHEA and testosterone across the pubertal transition: Effects of threat-related early life stress

King, Lucy S.; Graber, M.; Colich, Natalie L.; Gotlib, Ian H.

doi:10.1016/j.psyneuen.2020.104651

Cited by 37 publications

(21 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In another study from our sample of previously institutionalized youth, as the HPA axis recalibrated, the correlation with DHEA increased for youth with a history of early adversity (Howland et al, 2020). Results were similar for another research group examining the correlation of DHEA with cortisol in youth with and without a history of early adversity using saliva samples obtained immediately after waking in the morning (King et al, 2020). However, DHEA levels did not differ between previously institutionalized and comparison youth.…”

Section: Ev I De Nc E Of R Eca L I Br At Ion I N H U M a Nssupporting

confidence: 72%

The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

DePasquale

Herzberg

Gunnar

2021

Child Dev Perspectives

View full text Add to dashboard Cite

Events that threaten the physical or social self, or anticipation of such events, activate physiological systems that serve defensive functions, increasing chances of survival. The body's response to threat aims to achieve allostasis, or the maintenance of stability (i.e., functioning), through activation of stress-mediating systems (McEwen, 2000). Mammals have two core stress systems: the hypothalamic-pituitary-adrenocortical (HPA) system, with its primary glucocorticoid end product (cortisol in humans and corticosterone in rodents), and the sympathetic-adrenomedullary system and accompanying norepinephrine system in the locus coeruleus. Successfully activating these systems allows adaptation to immediate and future environments, while failing to maintain stability in response to environmental threats can lead to maladaptive outcomes. How environmental conditions shape these systems is critical to understanding the development of psychopathology, particularly following early adversity.Studies with rodents have provided valuable insight into the malleability of stress-responsive systems, including strong evidence of a sensitive period, roughly equivalent to the third trimester of pregnancy and the first months of life in humans, for establishing set points for the reactivity and regulation of the HPA system (Lupien et al., 2009). Along with emerging longitudinal evidence in humans, rodent models suggest the possibility of a second time of heightened plasticity during the peripubertal period, when the HPA system can recalibrate, provided the level of physical and social threats in the environment has changed from the earlier sensitive period (Francis et al., 2002;. Similar patterns have not been found for the

show abstract

Section: Ev I De Nc E Of R Eca L I Br At Ion I N H U M a Nssupporting

confidence: 72%

The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

DePasquale

Herzberg

Gunnar

2021

Child Dev Perspectives

View full text Add to dashboard Cite

show abstract

“…Although the ratio of cortisol and DHEA was widely examined and linked to depression [6,49,63,68], the theory has been criticized [4] and warrants further investigation before sound conclusions about the interplay between cortisol, DHEA and depression can be drawn [35], especially in adolescents. In addition, increase in DHEA and testosterone during adolescence was linked with increased cortisol concentrations and may affect cortisol regulation during the developmental stage of adolescence [53].…”

Section: Introductionmentioning

confidence: 99%

Hair androgen concentrations and depressive disorders in adolescents from the general population

Kische

Voß

Haring

et al. 2022

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Although the link between androgens and depression is well established in adults, the effects of cofactors on this association are less clearly understood, particularly in youth. Epidemiological cohort study of adolescents in Dresden, Germany. Analyses comprised data of 985 individuals assessed at baseline and of 512 individuals at 1-year follow-up. We investigated multivariable regression models for cross-sectional and longitudinal associations of hair testosterone, dehydroepiandrosterone (DHEA), and their cortisol ratios with 12-month diagnoses of major depressive disorder (MDD) and MDD without any anxiety disorder assessed with standardized diagnostic interview (DIA-X-5), and with dimensional depression scores (PHQ-9, PROMIS), separately for males and females. The potential moderating effect of social support was determined. Cross-sectional analyses yielded inverse associations of testosterone and DHEA with MDD and MDD without any anxiety disorders in males. In cross-sectional and longitudinal analyses, baseline ratio cortisol/DHEA was significantly, inversely associated to PROMIS-depression in males. Only cross-sectional associations for ratio cortisol/DHEA and PROMIS-depression remained significant after Bonferroni-Holm correction. No robust associations were observed in female participants. Social support exerted no consistent moderating effect on the investigated association. The present observational cohort study showed no consistent association of hair androgen concentrations with depressive disorders in adolescents. However, findings provide some support for the association between the cortisol/DHEA ratio and depression in males. Longitudinal research designs in large samples are needed to understand the interplay between androgens, depression, and developmental and social factors in youth.

show abstract

“…In addition, adolescents were recruited such that the majority were in early puberty at T1 based on self-reported Tanner stage (96% self-reported Tanner stage ≤ 3; Marshall and Tanner, 1968 ; Morris and Udry, 1980 ); further, boys and girls were matched on the basis of self-reported Tanner staging rather than age. Self-reported Tanner stage is significantly positively associated with pubertal hormones in this sample ( King et al, 2020 ). Given sex differences in pubertal timing ( Negriff and Susman, 2011 ), samples of adolescent boys and girls that are matched on age are confounded by sex differences in pubertal stage.…”

Section: Methodsmentioning

confidence: 74%

Cross-sectional and longitudinal associations of family income-to-needs ratio with cortical and subcortical brain volume in adolescent boys and girls

King

Dennis

Humphreys

et al. 2020

Developmental Cognitive Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

Associations of waking cortisol with DHEA and testosterone across the pubertal transition: Effects of threat-related early life stress

Cited by 37 publications

References 40 publications

The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

Hair androgen concentrations and depressive disorders in adolescents from the general population

Cross-sectional and longitudinal associations of family income-to-needs ratio with cortical and subcortical brain volume in adolescent boys and girls

Contact Info

Product

Resources

About