Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome

Wimalawansa, Sunil J.

doi:10.1016/j.jsbmb.2016.09.017

Cited by 222 publications

(185 citation statements)

References 190 publications

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“…It was evidenced that 1,25(OH)2D not only modulates cellular growth and differentiation, but also enhances the immune system (e.g., production of beta-defensin and cathelicidin, and modulation of production of anti-inflammatory cytokines: IL-4, IL-5) (7, 9, 45-52). In addition, it also increases the lymphocytic activity and stimulates insulin production (7,9,45,46). These findings help explaining many of the vitamin D actions and its association with the reduction of the risk of several diseases.…”

Section: Vitamin D: a Classic Perspective In Briefmentioning

confidence: 87%

Vitamin D supplementation guidelines

Płudowski

Holick

Grant

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

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525

438

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Section: Vitamin D: a Classic Perspective In Briefmentioning

confidence: 87%

Vitamin D supplementation guidelines

Płudowski

Holick

Grant

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

Self Cite

525

438

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“…Therefore, accumulating evidence suggests a highly complex role of vitamin D. It is noteworthy that vitamin D regulates several adipose tissue cytokines including leptin [123]. Recent evidence on the association between vitamin D deficiency and obesity clearly indicates that the functions of this vitamin are not limited to the maintenance of bone tissue and calcium metabolism [124], [125], [126], [127], [128].…”

Section: Characteristics Of Her2 Expressionmentioning

confidence: 99%

Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment

Ray

2017

Hormone Molecular Biology and Clinical Investigation

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Abstract:Obesity is associated with the risk of several health disorders including certain cancers. Among obesity-related cancers, postmenopausal breast carcinoma is a well-studied one. Apart from an increase in certain types of lipids in obesity, excess adipose tissue releases many hormone-like cytokines/adipokines, which are usually pro-inflammatory in nature. Leptin is one of such adipokines and significantly linked with the intracellular signaling pathways of other growth factors such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER2). In general, HER2 is overexpressed in roughly 30% of breast carcinomas; its presence indicates aggressive tumor behavior. Conversely, HER2 has certain effects in normal conditions such as differentiation of preadipocytes, cardiovascular health and vitamin D metabolism. HER2 has no known endogenous ligand, but it may form dimers with other three members of the epidermal growth factor receptor (EGFR) family and can activate downstream signaling pathways. Furthermore, HER2 is intimately connected with several enzymes, e.g. fatty acid synthase (FASN), phosphatidylinositol 3-kinase (PI3K), AKT and mechanistic target of rapamycin (mTOR), all of which play significant regulatory roles in lipogenic pathways or lipid metabolism. In obesity-related carcinogenesis, characteristics like insulin resistance and elevated IGF-1 are commonly observed. Both IGF-1 and leptin can modulate EGFR and HER2 signaling pathways. Although clinical studies have shown mixed results, the behavior of HER2+ tumor cells including HER2 levels can be altered by several factors such as obesity, leptin and fatty acids. A precise knowledge is useful in new therapeutic approaches against HER+ tumors.

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“…Many studies in recent years have further postulated an important role of vitamin D in several other physiological systems [1]. For example, vitamin D has been suggested to stimulate insulin secretion and decrease insulin resistance [2] and to also exert anti-cancer activity, including anti-proliferative and anti-inflammatory effects [3]. …”

Section: Introductionmentioning

confidence: 99%

25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies

Ekmekçioğlu

Haluza

Kundi

2017

IJERPH

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Epidemiological evidence suggests an association between low vitamin D status and risk for various outcomes including cardiovascular diseases, cancer, and type 2 diabetes mellitus (T2DM). Analyzing serum 25-hydroxyvitamin D [25(OH)D] is the most established means to evaluate an individual’s vitamin D status. However, cutoff values for 25(OH)D insufficiency as well as for optimal 25(OH)D levels are controversial. This systematic review critically summarizes the epidemiological evidence regarding 25(OH)D levels and the risk for colorectal cancer and T2DM. The meta-analytical calculation revealed a pooled relative risk (RR) of 0.62 (CI 0.56–0.70; I2 = 14.7%) for colorectal cancer and an RR of 0.66 (CI 0.61–0.73; I2 = 38.6%) for T2DM when comparing individuals with the highest category of 25(OH)D with those in the lowest. A dose–response analysis showed an inverse association between 25(OH)D levels and RR for both outcomes up to concentrations of about 55 ng/mL for colorectal cancer and about 65 ng/mL for T2DM. At still higher 25(OH)D levels the RR increases slightly, consistent with a U-shaped association. In conclusion, a higher 25(OH)D status is associated with a lower risk for colorectal cancer and T2DM; however, this advantage is gradually lost as levels increase beyond 50–60 ng/mL.

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Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome

Cited by 222 publications

References 190 publications

Vitamin D supplementation guidelines

Vitamin D supplementation guidelines

Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment

25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies

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