Associations of urinary polycyclic aromatic hydrocarbons with bone mass density and osteoporosis in U.S. adults, NHANES 2005–2010

Guo, Jìng; Huang, Yun; Bian, Suchen; Zhao, Chuning; Jin, Yumin; Yu, Dongdong; Wu, Xinkai; Zhang, Dan; Cao, Weiming; Jing, Fangyuan; Chen, Guangdi

doi:10.1016/j.envpol.2018.04.108

Cited by 50 publications

(21 citation statements)

References 45 publications

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“…BaP was shown to inhibit osteogenesis in rat bone marrow cells [67]. Furthermore, in humans, associations between the contents of urinary PAHs and bone mass density were stronger for postmenopausal women when compared with the premenopausal group [68]. Therefore, atmospheric PAHs influence mammalian bone metabolism.…”

Section: Toxicity Of Pahs On the Bone Metabolism Of Fishmentioning

confidence: 99%

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Honda

Suzuki

2020

IJERPH

380

126

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Polycyclic aromatic hydrocarbons (PAHs) are organic compounds that are widely distributed in the air, water, and soil. Recently, the amount of PAHs derived from fuels and from incomplete combustion processes is increasing. In the aquatic environment, oil spills directly cause PAH pollution and affect marine organisms. Oil spills correlate very well with the major shipping routes. Furthermore, accidental oil spills can seriously impact the marine environment toxicologically. Here, we describe PAH toxicities and related bioaccumulation properties in aquatic animals, including invertebrates. Recent studies have revealed the toxicity of PAHs, including endocrine disruption and tissue-specific toxicity, although researchers have mainly focused on the carcinogenic toxicity of PAHs. We summarize the toxicity of PAHs regarding these aspects. Additionally, the bioaccumulation properties of PAHs for organisms, including invertebrates, are important factors when considering PAH toxicity. In this review, we describe the bioaccumulation properties of PAHs in aquatic animals. Recently, microplastics have been the most concerning environmental problem in the aquatic ecosystem, and the vector effect of microplastics for lipophilic compounds is an emerging environmental issue. Here, we describe the correlation between PAHs and microplastics. Thus, we concluded that PAHs have a toxicity for aquatic animals, indicating that we should emphasize the prevention of aquatic PAH pollution.

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Section: Toxicity Of Pahs On the Bone Metabolism Of Fishmentioning

confidence: 99%

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Honda

Suzuki

2020

IJERPH

380

126

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“…Due to the episodic nature of exposure and variable pharmacokinetics, measurements of OH-PAHs made in a single spot urine may reflect a recent exposure, and may not represent an integrated exposure over time. Several biomonitoring studies have measured OH-PAH concentrations in spot urine or first morning void samples ( Guo et al 2018 ; Urbancova et al 2017 ; Wang et al 2019b ). For those chemicals that have temporal variations in exposure, analysis of a single spot urine sample to generalize long-term exposure will lead to exposure misclassification and, consequently, biased dose-response functions.…”

Section: Introductionmentioning

confidence: 99%

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Zhu

Martinez-Moral

Kannan

2021

Environment International

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants. Urinary concentrations of mono-hydroxylated metabolites of PAHs (OH-PAHs) have been used as biomarkers of these chemicals’ exposure in humans. Little is known, however, with regard to intra- and inter-individual variability in OH-PAH concentrations and their association with oxidative stress. We conducted a longitudinal study of measurement of urinary concentrations of 15 OH-PAHs and 7 oxidative stress biomarkers (OSBs) of DNA damage [8-hydroxy-2′-deoxyguanosine (8-OHdG)], lipid [malondialdehyde (MDA) and F 2 -isoprostanes (PGF 2α )] and protein [ o,o ′ -dityrosine (diY)] peroxidation in 19 individuals for 44 consecutive days. Metabolites of naphthalene (OHNap), fluorene (OHFlu), phenanthrene (OHPhe), and pyrene (OHPyr) were found in >70% of 515 urine samples analyzed, at sum concentrations (∑OH-PAH) measured in the range of 0.46–60 ng/mL. After adjusting for creatinine, OHNap and ∑OH-PAH concentrations exhibited moderate predictability, with intra-class correlation coefficients (ICCs) ranging from 0.359 to 0.760. However, ICC values were low (0.001–0.494) for OHFlu, OHPhe, and OHPyr, which suggested poor predictability for these PAH metabolites. Linear mixed-effects analysis revealed that an unit increase in ∑OH-PAH concentration corresponded to 4.5%, 5.3%, 20%, and 21% increase in respective urinary 8-OHdG, MDA, PGF 2α , and diY concentrations, suggesting an association with oxidative damage to DNA, lipids, and proteins. The daily intakes of PAHs, calculated from urinary concentrations of OH-PAHs, were 10- to 100-fold below the current reference doses. This study provides valuable information to design sampling strategies in biomonitoring studies and in assigning exposure classifications of PAHs in epidemiologic studies.

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“…The BMI was calculated by using weight (kg) divided by the square of height (m). The leisure-time physical activity was categorized into four groups based on metabolic equivalent (MET)-minutes per week: sedentary (MET = 0), insufficient (0 < MET ≤ 500), moderate (500 < MET ≤ 1,000), and high (MET > 1,000) ( 17 ). The information on total dietary energy, protein, carbohydrate, lipids, and fiber intake was obtained from a 24-h dietary recall.…”

Section: Methodsmentioning

confidence: 99%

Association Between Water Intake and Mortality Risk—Evidence From a National Prospective Study

et al. 2022

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BackgroundFew studies have explored the association between water intake and mortality risk, and the findings were inconsistent.ObjectiveThis study aimed to explore the water intake–mortality association, utilizing the data from the National Health and Nutrition Examination Survey (NHANES) and the 2015 public-linked mortality files released by the National Center for Health Statistics.MethodsWe used the diet- and mortality-linked data of a total of 35,463 adults (17,234 men) aged ≥20 years in the NHANESs 1999–2014 to perform a prospective study. The multivariate-adjusted Cox proportional hazards model was used to explore the associations of the amount of water intake (expressed by total water, plain water, beverage, and food water) and water intake proportion (expressed by the percentage of each kind of water) with mortality risks due to all causes, malignant neoplasms/cancer, and heart disease. The restricted cubic spline plots were adopted to clarify the dose–response relationships among them.ResultsWith a median of 88 months (interquartile range: 49–136 months) follow-up, a total of 4,915 all-cause deaths occurred, including 1,073 and 861 deaths from malignant neoplasms/cancer and heart disease, respectively. The amount of water intake in either type was negatively associated with all-cause mortality risk. Additionally, the negative linear dose–response relationships of water intake and all-cause mortality risk were found for all types of water except for food water, which followed a non-linear pattern. Similarly, compared to the lowest quartile (beverage water intake: <676 g/day; food water intake: <532 g/day), beverage and food water intakes in the range of 1,033–1,524 and 1,612–3,802 g/day were associated with decreased malignant neoplasms/cancer mortality risk. A U-shaped dose–response relationship was found for beverage water intake and malignant neoplasms/cancer mortality risk and a negative linear dose–response relationship was found for food water intake and malignant neoplasms/cancer mortality risk. Coffee and/or tea consumption was/were negatively associated with mortality risks due to all causes and malignant neoplasms/cancer. No significant associations of water intake proportion and mortality risks were found.ConclusionOur findings demonstrated that higher water intake is associated with lower mortality risks among the United States population.

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Associations of urinary polycyclic aromatic hydrocarbons with bone mass density and osteoporosis in U.S. adults, NHANES 2005–2010

Cited by 50 publications

References 45 publications

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Association Between Water Intake and Mortality Risk—Evidence From a National Prospective Study

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