Associations of urinary organophosphate esters metabolites and diet quality with nonalcoholic/metabolic dysfunction-associated fatty liver diseases in adults

Aimuzi, Ruxianguli; Xie, Zhilan; Qu, Yimin; Jiang, Yangfu; Luo, Kai

doi:10.1016/j.ecoenv.2023.114720

Cited by 10 publications

(3 citation statements)

References 63 publications

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“…Previous research suggested that human exposure to OPEs were closely related to the lifestyle, such as dietary habits (Su et al, 2024a). A study conducted by Aimuzi et al (2023) found that participants with low BDCIPP levels and high diet quality had lowest odds of hepatic metabolic disorders compared to those with high BDCIPP levels and low diet quality.…”

Section: Discussionmentioning

confidence: 99%

Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among Chinese adults

Xu,

Xie,

Yang

et al. 2024

Preprint

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Toxicologic studies reported that organophosphate esters (OPEs) may disrupt lipid metabolism, thus affecting serum lipid levels. However, epidemiological evidences regarding the association between OPEs and the risk of hyperlipidemia (HPL) as well as serum lipid levels are scarce. In the present study, our aim was to investigate the impact of individual and mixed OPEs exposure on HPL. A total of 1981 Chinese adults were involved based on a cross-sectional design. Overall, we found a positive association between bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and the risk of HPL. Bis(1-chloro-2-propyl) phosphate (BCIPHIPP) showed a positive association with total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). BDCIPP, diphenyl phosphate (DPHP), di-ocresyl phosphate and di-p-cresyl phosphate (Docp&Dpcp) as well as 4-hydroxyphenyl-diphenyl phosphate (4-OH-DPHP) exhibited a negative association with high-density lipoprotein cholesterol (HDL-C). In stratified analyses, BDCIPP and BCIPHIPP were significantly correlated with the increase risk of HPL in age ≤45 group. Bis (2-butoxyethyl) phosphate (BBOEP) was in relationship with an elevated risk of HPL in the subgroup of BMI < 24 kg/m2. BDCIPP was also positively associated with HPL in men. Quantile-based g computation (qgcomp) and generalized Weighted Quantile Sum Regression (gWQS) models demonstrated a negative association between OPEs mixed exposure and HDL-c in total population, as well as a positive effect of them on HPL in the subgroup of age ≤45 year, which is consistent with the individual analyses. Furthermore, joint effect analyses of revealed that participants with detected BDCIPP urinary levels and unhealthy lifestyle had the highest risk of HPL. Our findings offer evidence supporting the correlation between exposure to OPE and the risk of HPL, necessitating further prospective studies for validation.

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Section: Discussionmentioning

confidence: 99%

Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among Chinese adults

Xu,

Xie,

Yang

et al. 2024

Preprint

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“…Metabolites of the investigated EDCs were used as biomarkers of exposure (Table ). The biomarkers were selected based on (1) the response relationship between each parent compound and the biomarker and (2) the detection frequencies among reported populations, which exceeded 50%. − For the detection of OFR metabolites (mOFRs), 100 μL of 200 ng/mL mixed internal standards (IS) (i.e., d 8-BBOEP, d 8-BCEP, d 12-BCIPP, d 10-BDCIPP, d 18-DBP, d 14-DoCP, d 14-DpCP, and d 10-DPHP) and 12 μL of formic acid were added to 2 mL of urine. After cartridge activation with 2 mL of 5% NH 4 OH in methanol and 3 mL of 0.6% formic acid in water, solid-phase extraction was conducted using CNW polysery PWAX cartridges.…”

Section: Methodsmentioning

confidence: 99%

Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Zhang,

Liu,

et al. 2024

Environ. Health

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There is a lack of human evidence concerning the cardiovascular effects of combined exposure to endocrine disruptors. This case-control study sought to investigate coronary heart disease (CHD) associations with exposure to organophosphate flame retardants (OFRs), phthalates (PAEs), and polycyclic aromatic hydrocarbons (PAHs) among 148 adults with coronary-angiography-diagnosed CHD and 320 healthy adults from southern China. The mediating role of glucose-lipid metabolism was also explored. Bayesian kernel machine regression suggested that when exposure status was fixed to the 75th percentile with the median value as the reference, exposure to OFRs, PAEs, and PAHs was associated with an 84% (95% CI: 36%−134%), 132% (12%−252%), and 214% (89%−331%) increased risk of developing CHD, respectively. Weighted quantile sum regression indicated urinary bis(2-butoxyethyl) phosphate (BBOEP), dibutyl phosphate (DBP), monoisononyl phthalate (miNP), and metabolites of phenanthrene may be major contributors to the overall effect of mixtures. In further analyses on identified chemical risk factors, mediation analyses suggested exposure to phenanthrene may increase the risk of CHD via elevating total cholesterol and blood glucose, while exposure to DiNP mainly associates with serum lipids. Besides, we observed a slight mediation effect of oxidative DNA damage between urinary BBOEP and risk of CHD. These results provide potential direction for further experimental studies. Longitudinal evidence is needed to clarify the causation of the results.

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“…Despite adoption of the same operational definitions for NAFLD and MAFLD among studies, the differences in prevalence estimates from NHANES III demonstrate the inter-reporter variability in epidemiologic studies in fatty liver disease has not been remedied by the nomenclature change. Contemporary iterations of NHANES validate that MAFLD marginally increases fatty liver disease prevalence in the USA, whether case ascertainment is through the United States Fatty Liver Index (US-FLI) or accepted elastographic parameters on vibration-controlled transient elastography (VCTE) [ 23 – 25 ]. A study by Wong et al from NHANES 2011–2018 reported that MAFLD prevalence increased from 34.4% to 38.1% ( p < 0.01) between 2011 to 2018, with 7.6% of MAFLD patients having concomitant liver disease (5.5% alcohol-related, 1.6% hepatitis C, 0.5% chronic hepatitis B [CHB]) [ 26 ].…”

Section: Prevalencementioning

confidence: 99%

Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes

et al. 2023

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Introduction For the first time in nearly half a century, fatty liver disease has undergone a change in name and definition, from the exclusive term, non-alcoholic fatty liver disease (NAFLD), to the inclusion-based, metabolic-associated fatty liver disease (MAFLD). This has led investigators across the globe to evaluate the impact the nomenclature change has had on the epidemiology and natural history of the disease. Methods This systematic review provides a comprehensive overview on how the shift in name and diagnostic criteria has influenced point prevalence in different geographic regions, as well as morbidity and mortality risk, whilst highlighting gaps in the literature that need to be addressed. Conclusions MAFLD prevalence is higher than NAFLD prevalence, carries a higher risk of overall mortality, with greater granularity in risk-stratification amongst MAFLD subtypes. Graphical abstract

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Associations of urinary organophosphate esters metabolites and diet quality with nonalcoholic/metabolic dysfunction-associated fatty liver diseases in adults

Cited by 10 publications

References 63 publications

Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among Chinese adults

Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among Chinese adults

Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes

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