Associations of trace element levels in paired serum, whole blood, and tissue: an example of esophageal squamous cell carcinoma

Cao, Kexin; Zhang, Jingbing; Wang, Geng; Lin, Xiaosheng; Zhan, Fulan; Wu, Kusheng; Wang, Tan; Geng, Hui; Liu, Caixia

doi:10.1007/s11356-022-24960-z

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…They suggested that the higher Cu concentration detected in other studies may indirectly result from smoking-related diseases rather than smoking itself [ 41 ]. Interestingly, compared with healthy individuals, the serum Cu concentration is also higher in lung cancer patients [ 42 ] and esophageal cancer patients [ 43 ], although this may be a result rather than the cause of carcinogenesis. Even if a higher concentration of Cu does not cause carcinogenesis, it promotes uncontrolled proliferation of cancer cells because they have a higher demand for Cu than non-dividing cells [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

et al. 2023

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Tobacco smoking is deleterious to the lungs because it exposes them to many toxic substances. These include transition metal ions, such as cadmium. However, there is a lack of information about the influence of endogenous metal-binding peptides, such as His-Leu (HL), on the lung distribution of transition metals in smokers. To address this, we administered HL subcutaneously to rats exposed to tobacco smoke for six weeks, then we measured the concentrations of transition metal ions in the lungs. We found that exposure to tobacco smoke elevates the concentrations of Cd(II) and Cu(II). Administration of the HL peptide, whose elevation is a consequence of angiotensin receptor blocker anti-hypertension therapy, increases the concentration of Fe in the lungs of rats exposed to smoke. These findings suggest that smoking is a risk factor for patients receiving angiotensin receptor blockers to treat hypertension.

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Section: Resultsmentioning

confidence: 99%

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

et al. 2023

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“…Environmental exposure to many metals and metalloids is widespread, raising global concerns about the adverse health effects of mixed metal exposures, especially for young children living around industrial areas [19]. Salts of heavy metals play the role of trace elements [4]. These elements, like vitamins, are needed by the human body for its normal functioning.…”

Section: Introductionmentioning

confidence: 99%

Density of lymphocytes in cortex and medulla substance of thymus particles of white rats in normal conditions and under influence of heavy metal salts during three months

Dobryanska,

Vatsyk,

Litvak

2024

Rep. of Morph.

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The consumption of clean water is the most relevant today, but natural water is delivered to our homes through plastic, iron and galvanized pipes. Metal ions, which are part of the pipe material, can get into drinking water and affect the human body, in particular the thymus. That is why the aim of the work was to determine the density of large, medium and small lymphocytes in the cortex and medulla of the thymus lobules of outbred white male rats of reproductive age when consuming small doses of heavy metal salts with water for three months. The study was conducted on 40 outbred white male rats of reproductive age, which were divided into 4 groups: 1 group – control animals that consumed distilled water; 2 group of animals that consumed aqueous solutions – CuSO4·5H2O at a dose of 0.247 mg/dm3; 3 group – aqueous solution of ZnSO4·7H2O at a dose of 1.505 mg/dm3; group 4 – aqueous solution of FeSO4·7H2O at a dose of 0.5 mg/dm3. Histological, electron microscopic and morphometric research methods were used to study the density of large, medium and small lymphocytes in different zones of the thymus lobules. It was found that in the control group of rats, the density of large lymphocytes is the highest in the subcapsular zone, and the lowest in the medulla. The density of medium lymphocytes is the lowest in the subcapsular zone. The density of small lymphocytes is the lowest in the medulla, and the highest in the cortico-medullary zone. When using CuSO4·5H2O salts with drinking water for three months, there were no significant changes in the density of lymphocytes compared to the control group, except for a slight decrease in the density of large lymphocytes in the cortex of the thymus lobules. The density of lymphocytes in the third group of animals that consumed zinc salts (ZnSO4·7H2O) with drinking water changes significantly: the density of large lymphocytes in the subcapsular zone decreases by 2.3 times, in the cortico-medullary zone it increases by 4.7 times, and in the medulla it increases by 2.7 times; the density of medium lymphocytes decreases in the subcapsular zone by 2 times; the density of small lymphocytes decreases by 1.5 times in the subcapsular zone, in the cortex and cortico-medullary zone – decreases by 1.2 times, and in the medulla by 1.1 times. When using FeSO4·7H2O salts with drinking water for three months, no special changes in the density of lymphocytes were noted: a decrease in the density of large lymphocytes in the subcapsular zone by 1.5 times and by 1.3 times in the cortex was observed; the density of medium lymphocytes decreases by 1.2 times in the cortex, and the density of small lymphocytes decreases by 1.2 times in the subcapsular zone and cortex, and increases by 1.2 times in the medulla, compared to the control group of animals. Ultrastructural changes in the structure of lymphocytes and reticuloepithelial cells were not detected when heavy metal salts were consumed with water. Thus, the study showed that the most toxic for the body are zinc salts (ZnSO4·7H2O), the consumption of which with drinking water in small doses for three months led to significant changes in the density of lymphocytes, compared to the control group experimental animals.

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Associations of trace element levels in paired serum, whole blood, and tissue: an example of esophageal squamous cell carcinoma

Cited by 2 publications

References 46 publications

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

Density of lymphocytes in cortex and medulla substance of thymus particles of white rats in normal conditions and under influence of heavy metal salts during three months

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