Associations of the Triglyceride and Glucose Index With Hypertension Stages, Phenotypes, and Their Progressions Among Middle-Aged and Older Chinese

Shan, Shiyi; Li, Shuting; Lu, Keyao; Cao, Jin; Sun, Weidi; Zhou, Jiali; Ren, Ziyang; Zhu, Siyu; Hou, Leying; Chen, Dingwan; Song, Peige

doi:10.3389/ijph.2023.1605648

Cited by 6 publications

(3 citation statements)

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“…Previous studies have con rmed the TyG index was associated with hypertension [10-13, 15, 29, 30] [31]. Another large population-based study (n = 47,808) also reported TyG index signi cantly associated with hypertension in either total subjects or subjects separated into men and women [13].…”

Section: Discussionmentioning

confidence: 75%

“…Our study observed that females had signi cant higher risk of hypertension in the "moderate increasing" and "high stable" TyG index trajectories than males. Another study based on middle-aged and older Chinese, using China Health and Retirement Longitudinal Study (CHARLS) data, also found that higher TyG index was signi cantly associated with stage 2 hypertension in females, but not in males [31]. However, previous study from Spanish cohort has reported that the top quintile of TyG index in men had two times more likely to develop hypertension than those in the bottom quintile, and the effect was attenuated in women [36].…”

Section: Discussionmentioning

confidence: 94%

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The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study

Xin,

He,

Zhou

et al. 2023

Preprint

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Background Previous studies have found that the triglyceride glucose index (TyG index ) trajectories are associated with cardiovascular diseases. However, the association between the patterns of TyG index trajectories and risk for hypertension has not been investigated. In a longitudinal general population, we aimed to identify distinct TyG index trajectories over 12 years and describe their association with incidence of hypertension. Method Of the 15,056 adults retrospectively recruited from the Physical Examination Center of the Second Affiliated Hospital of Dalian Medical University in northeast of China from 2011 to 2022. TyG index was calculated as The TyG index was measured ln (fasting TG [mg/dL] ×FPG [mg/dL]/2) and the TyG index trajectories were developed using group-based trajectory modelling. Cox regression analysis was accomplished to assess the association between TyG index and incidence of hypertension. Results The median age of the population was 38 years, and 7,352 (48.83%) of the participants were men. Three distinct TyG index trajectories were identified: “low increasing” (N = 7,241), “moderate increasing” (N = 6,448), and “high stable” (N = 1,367). Using “low increasing” trajectory as a reference, “moderate increasing” and “high stable” trajectory were associated with increased risk of hypertension (HR = 2.45; 95%CI 2.25-2.67 and HR = 3.88; 95%CI 3.48-4.33). After adjusting for baseline sex, age, diabetes, smoking, systolic blood pressure, diastolic blood pressure, BMI, cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, blood glucose, triglyceride, urea, uric acid, and glomerular filtration rate, the HR were slightly attenuate in “moderate increasing” and “high stable” trajectories to 1.38 (95%CI 1.23-1.54) and 1.69 (95%CI 1.40-2.02) respectively. Meanwhile, similar results were observed in multiple sensitivity analyses. The HR of the “moderate increasing” and “high stable” trajectory groups were 2.63 (95% CI 2.30-3.00) and 4.66 (95% CI 3.66-5.93) in female, and 1.66 (95% CI 1.48-1.86) and 2.33 (95% CI 2.04-2.66) in male. Conclusions Elevated TyG index at baseline and long-term TyG index trajectories were associated with the risk of hypertension. Early identification of increasing TyG index could provide insights for preventing hypertension later in life.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 94%

The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study

Xin,

He,

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The TyG index, which is produced from fasting triglyceride and glucose levels, has been widely used as a key marker of IR, particularly peripheral and hepatic IR. Several epidemiological studies have reported a significant association of higher TyG scores with the risk of type 2 diabetes mellitus (T2DM) ( 31 , 32 ), prediabetes ( 33 ), hypertension ( 34 ), cardiovascular disease (CVD) ( 35 ), coronary artery calcification ( 36 ), and polycystic ovary syndrome (PCOS) ( 37 ), which can be explained by IR. Mechanically, IR may explain the link between the TyG index and lean NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Association between TyG index trajectory and new-onset lean NAFLD: a longitudinal study

Liu,

Chen,

Qin

et al. 2024

Front. Endocrinol.

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ObjectiveThe purpose of this manuscript is to identify longitudinal trajectories of changes in triglyceride glucose (TyG) index and investigate the association of TyG index trajectories with risk of lean nonalcoholic fatty liver disease (NAFLD).MethodsUsing data from 1,109 participants in the Health Management Cohort longitudinal study, we used Latent Class Growth Modeling (LCGM) to develop TyG index trajectories. Using a Cox proportional hazard model, the relationship between TyG index trajectories and incident lean NAFLD was analyzed. Restricted cubic splines (RCS) were used to visually display the dose-response association between TyG index and lean NAFLD. We also deployed machine learning (ML) via Light Gradient Boosting Machine (LightGBM) to predict lean NAFLD, validated by receiver operating characteristic curves (ROCs). The LightGBM model was used to create an online tool for medical use. In addition, NAFLD was assessed by abdominal ultrasound after excluding other liver fat causes.ResultsThe median age of the population was 46.6 years, and 440 (39.68%) of the participants were men. Three distinct TyG index trajectories were identified: “low stable” (TyG index ranged from 7.66 to 7.71, n=206, 18.5%), “moderate stable” (TyG index ranged from 8.11 to 8.15, n=542, 48.8%), and “high stable” (TyG index ranged from 8.61 to 8.67, n=363, 32.7%). Using a “low stable” trajectory as a reference, a “high stable” trajectory was associated with an increased risk of lean-NAFLD (HR: 2.668, 95% CI: 1.098-6.484). After adjusting for baseline age, WC, SBP, BMI, and ALT, HR increased slightly in “moderate stable” and “high stable” trajectories to 1.767 (95% CI:0.730-4.275) and 2.668 (95% CI:1.098-6.484), respectively. RCS analysis showed a significant nonlinear dose-response relationship between TyG index and lean NAFLD risk (χ2 = 11.5, P=0.003). The LightGBM model demonstrated high accuracy (Train AUC 0.870, Test AUC 0.766). An online tool based on our model was developed to assist clinicians in assessing lean NAFLD risk.ConclusionThe TyG index serves as a promising noninvasive marker for lean NAFLD, with significant implications for clinical practice and public health policy.

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Relationship between triglyceride-glucose index and carotid artery plaques in ischemic stroke patients: Based on blood pressure status, sex, and age

Zou,

Li,

Zhang

et al. 2024

Journal of Stroke and Cerebrovascular Diseases

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Associations of the Triglyceride and Glucose Index With Hypertension Stages, Phenotypes, and Their Progressions Among Middle-Aged and Older Chinese

Cited by 6 publications

References 58 publications

The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study

The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study

Association between TyG index trajectory and new-onset lean NAFLD: a longitudinal study

Relationship between triglyceride-glucose index and carotid artery plaques in ischemic stroke patients: Based on blood pressure status, sex, and age

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