Associations of the &lt;em&gt;MTHFR&lt;/em&gt; rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

Han, Zhiqiang; Huaming, Sheng; Gao, Qingkun; Fan, Yu; Xie, Xiang

doi:10.3892/br.2020.1390

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…However, the risk of developing GC in individuals carrying the TT genotype of the C677T polymorphism compared with those with CC was not higher; regarding the genotypes, no difference was found in the life spans of the patients [ 135 ]. Recently, in a case ( n = 307) control ( n = 560) study in a Chinese Han population, patients carrying the TT genotype of C677T polymorphism were associated with a decreased risk of GC in older individuals and patients who never drank alcohol [ 136 ] Moreover, the relationship of the MTHFR C677T polymorphism and the combined use of alcohol and smoking have a coordinate effect influencing GC risk [ 137 ]. However, a meta-analysis of 5757 cases and 8501 controls of Asian and Caucasian patients found different results: a significant association was found between the GC and MTHFR C677T polymorphisms (homozygous model [TT vs. CC]: OR, 1.39; 95% CI, 1.20–1.62; heterozygous model [CT vs. CC]: OR, 1.18; 95% CI, 1.05–1.32; dominant model [TT + CT vs. CC]: OR, 1.23; 95% CI, 1.10–1.38; recessive model [TT vs. CC + CT]: OR, 1.26; 95% CI, 1.12–1.42) [ 138 ].…”

Section: Mthfr C677t and A1298c Polymorphisms And Gastric Cancermentioning

confidence: 99%

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

Petrone

Bernardo

Santos

et al. 2021

Genes

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Folate (vitamin B9) is found in some water-soluble foods or as a synthetic form of folic acid and is involved in many essential biochemical processes. Dietary folate is converted into tetrahydrofolate, a vital methyl donor for most methylation reactions, including DNA methylation. 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine. MTHFR polymorphisms result in reduced enzyme activity and altered levels of DNA methylation and synthesis. MTHFR polymorphisms have been linked to increased risks of several pathologies, including cancer. Breast cancer, gliomas and gastric cancer are highly heterogeneous and aggressive diseases associated with high mortality rates. The impact of MTHFR polymorphisms on these tumors remains controversial in the literature. This review discusses the relationship between the MTHFR C677T and A1298C polymorphisms and the increased risk of breast cancer, gliomas, and gastric cancer. Additionally, we highlight the relevance of ethnic and dietary aspects of population-based studies and histological stratification of highly heterogeneous tumors. Finally, this review discusses these aspects as potential factors responsible for the controversial literature concerning MTHFR polymorphisms.

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Section: Mthfr C677t and A1298c Polymorphisms And Gastric Cancermentioning

confidence: 99%

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

Petrone

Bernardo

Santos

et al. 2021

Genes

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“…Notably, the maximum sample sizes in studies exploring the association between MTHFR C677T and A1298C polymorphisms and susceptibility to GC were 27 and 12, respectively, compared with published meta-analyses. Furthermore, the latest years of previous meta-analyses on MTHFR C677T and A1298C polymorphisms and GC susceptibility were 2017 [ 17 ] and 2014 [ 19 ], respectively, and most of the studies included in the published meta-analyses focused on studies before 2014, whereas the latest study [ 71 ] we included was 2021. Reviewing past studies, Shen et al [ 30 ] first investigated the association between MTHFR gene polymorphisms and GC in 2001 and showed its possible association with GC risk in a Chinese Han population.…”

Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility: an updated meta-analysis

et al. 2023

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Widely regarded as one of the most prevalent malignancies worldwide, gastric cancer (GC) is a common clinical condition of the digestive system. Reviewing 14 meta-analyses that evaluated the association between Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and GC risk, we observed inconsistent results, and the credibility of the significant correlation between the statistical results was ignored. With the aim of further exploring the association between MTHFRC677T and CA1298C and the risk of GC, we searched electronic databases, pooling 43 relevant studies and calculating odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for each of the five genetic models. Subgroup and regression analyses were performed to look for sources of heterogeneity and publication bias was assessed by funnel plots. To assess the plausibility of statistically significant associations, we used the FPRP test and the Venice criteria. Overall data analysis showed that MTHFRC677T polymorphism was significantly associated with GC risk, especially in Asians, while MTHFR CA1298C polymorphism was not associated with GC risk. However, in subgroup analysis by hospital-based controls, we found that MTHFR CA1298C might be a protective factor for GC. After credibility assessment, the statistical association between MTHFRC677T and GC susceptibility study was classified as "less credible positive result", while the result of MTHFR CA1298C was considered unreliable. In summary, this study strongly suggests that MTHFR, C677T and CA1298C polymorphisms are not significantly associated with the GC risk.

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“…In a case-control study [33] of a Chinese Han population, single nucleotide polymorphisms in MTHFRRS1801133 were found to increase GC risk in both recessive (OR = 1.31, 95% CI, 1.01 -1.70; p = 0.042) and log-additive models (OR = 1.19, 95% CI, 1.02 -1.38; p = 0.025) in terms of GC risk. However, another hospital-based case-control study [34] showed that the RS1801133-TT genotype was associated with a significantly lower risk of gastric cancer in a Han Chinese population and that this association was evident in older patients and in patients who never drank alcohol. a prospective study by Öksüz E [30] showed that the MTHFR RS1801131 polymorphism may be a gastric cancer in eastern Turkey risk factor, with individuals with AC and CC genotypes having a 4.13fold (P = 0.001) and 2.19-fold (P = 0.027) higher risk of GC than those carrying the AA genotype, respectively, however, individuals with the TT genotype with the C677T polymorphism did not have a higher risk of gastric and oesophageal cancer compared to those with the 677CC genotype, and MTHFR RS1801133…”

Section: Correlation Of Mthfr Gene Polymorphisms With Gastric Cancermentioning

confidence: 97%

Research Progress on <i>MTHFR</i> C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors

Wang¹,

Huo²,

Huang³

et al. 2023

JBM

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Tumours of the digestive system include a number of malignant tumours such as oesophageal, gastric and colorectal cancers, which have the highest incidence and mortality rates in the world. Their occurrence is related to a variety of factors, such as diet, environment and genetics. As a key enzyme in the process of folate metabolism, MTHFR gene polymorphism plays an important role in the pathogenesis and development of gastrointestinal tumours.This paper provides a brief review of the relationship between MTHFR polymorphisms and digestive tumours, with a view to identifying the genetic effects of MTHFR, exploring the pathogenesis of digestive tract tumours and developing more effective prevention and treatment strategies.

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Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

Cited by 6 publications

References 47 publications

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility: an updated meta-analysis

Research Progress on <i>MTHFR</i> C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors

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Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

Cited by 6 publications

References 47 publications

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility: an updated meta-analysis

Research Progress on &lt;i&gt;MTHFR&lt;/i&gt; C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors

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Research Progress on <i>MTHFR</i> C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors