Associations of the IL‐1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population

Abstract

Our aim was to investigate whether genetic polymorphism of IL-1Beta-511, IL-1RN, TNF-A-308 are involved in the susceptibility to duodenal ulcer (DU). 437 unrelated Chinese Han patients with DU and 148 healthy controls were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method for the IL-1B-511, TNF-A-308 gene polymorphisms and the VNTR polymorphism in intron 2 of the IL-1RN gene polymorphisms. There was no difference in the genetic polymorphism of IL-1Beta-511, IL-1RN and TNF-A-308 in the patients with DU compared with control. After stratified by Helicobacter pylori infection, they also could not reach significant differences in this study. No statistically significant differences were observed in DU group compared with control according to combination of the IL-1Beta-511 and IL-1RN genotypes regardless of H. pylori positivity. These findings show that no evidence for the involvement of a proinflammatory polymorphism in the IL-1Beta-511, IL-1RN and TNF-A-308 in the susceptibility to DU in China.

Investigation of -308G>A and -1031T>C Polymorphisms in the TNFA Promoter Region in Polish Peptic Ulcer Patients

“…This finding is in agreement with some of previously published results for peptic ulcer patients. No association was stated between PUD incidence and -308G>A TNFA polymorphism in Koreans,13 duodenal ulcers and -308G>A or -1031T>C in eastern Indians,9 or duodenal ulcer disease and -308G>A variation in Chinese Han population 23. On the other hand, Lu et al 7.…”

“…showed that -1031T>C and -863C>A are host factors determining the risk of peptic ulceration upon H. pylori infection among Taiwanese, which implies the presence of some, not fully known ethnicity-related factors influencing the risk of PUD. In addition, it should be noticed that there are differences among studies in choosing control group (healthy volunteers9,13,23 or dyspeptic patients7) which may produce discrepancies in the results. As the sample size used in the research is relatively small, the results should be considered as preliminary and verified in larger groups.…”

No association between IL-1β −511 C/T polymorphism and the risk of duodenal ulcer: A meta-analysis of 4667 subjects

“…One study demonstrated that the −511 T/T genotype conferred a high risk for H. pylori-infected individuals to develop DU (Chakravorty et al, 2006). Other studies found no association (Chang et al, 2008;Erzin Garcia-Gonzalez et al, 2005;Hsu et al, 2004;Kim et al, 2006;Li et al, 2007;Mei et al, 2010;Melo Barbosa et al, 2009;Queiroz et al, 2005;Shin et al, 2008;Sugimoto et al, 2007). We performed a meta-analysis to assess whether combined evidence shows the association between IL-1β −511 C/T polymorphism and DU with and without H. pylori infection.…”

“…Our initial search identified a total of 251 potentially eligible articles. Based on our inclusion criteria, a total of 14 studies were involved in this meta-analysis (Chakravorty et al, 2006;Chang et al, 2008;Erzin et al, 2008;Furuta et al, 2002;García-González et al, 2003;Garcia-Gonzalez et al, 2005;Hsu et al, 2004;Kim et al, 2006;Li et al, 2007;Mei et al, 2010;Melo Barbosa et al, 2009;Queiroz et al, 2005;Shin et al, 2008;Sugimoto et al, 2007). There was perfect inter-rater reliability for the selection of studies to be included in the meta-analysis, with Kappa values of 0.89 based on titles and abstracts and 0.92 based on full texts.…”

Genetic Susceptibility of Gastroduodenal Disease in Ethnic and Regional Diversity

“…Numerous single nucleotide polymorphism (SNP) studies have been undertaken to identify candidate genes that most likely play a role in the development of peptic ulcers and gastric cancer 4–8. Recently, a genome wide association study (GWAS) and next generation sequencing study identified several genetic loci that confer susceptibility for H. pylori infection and gastroduodenal disease 9,10…”