Associations of testosterone and cortisol concentrations with sleep quality in Japanese male workers

Hirokawa, Kumi; Fujii, Yasuhito; Taniguchi, Takao; Tsujishita, Morihiro

doi:10.1016/j.cpnec.2022.100158

Cited by 2 publications

(2 citation statements)

References 46 publications

(63 reference statements)

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“…A cohort study showed that women with less frequent awakenings had higher T concentrations 24 . Low T concentrations have also been reported in middle‐aged men who reported nocturnal awakenings 25 . We hypothesize that independent of sleep duration, among middle‐aged women, a greater number of awakenings would lead to a disruption of the deeper sleep stage (SWS), which would cause a reduction in T concentrations.…”

Section: Discussionmentioning

confidence: 87%

“…24 Low T concentrations have also been reported in middle-aged men who reported nocturnal awakenings. 25 We hypothesize that independent of sleep duration, among middle-aged women, a greater number of awakenings would lead to a disruption of the deeper sleep stage (SWS), which would cause a reduction in T concentrations. In contrast, although the middle-aged men had a shorter sleep duration, they could have a smaller number of awakenings.…”

Section: Ta B L Ementioning

confidence: 99%

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Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

et al. 2023

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BackgroundThe association between testosterone concentrations and sleep duration is poorly understood.ObjectiveTo evaluate the association between sleep duration and quality with serum testosterone concentrations and its variation by sex and age.MethodsData were analyzed for 8748 men and women (≥20 years old) who participated in the cycles of the National Health and Nutrition Examination Survey 2011–2016, a cross‐sectional study. Total testosterone (ng/dL) was measured and categorized (low, moderate, and high) based on established cut‐offs for men and its tertile distribution among women. Sleep duration was classified as ≤6, 7–8, and ≥9 h. Sleep quality was classified as poor or good based on the frequency of trouble falling or staying asleep or sleeping too much. Weighted multivariable adjusted and multinomial logistic regression models were conducted to assess these associations.ResultsThe association between sleep duration and testosterone concentrations, varied according to sex and age. Sleep deprivation (≤6 h) was associated with high testosterone (odds ratio = 3.62; 95% confidence interval: 1.37, 9.53) among young men (20–40 years old); meanwhile, middle‐aged men (41–64 years old) who reported more sleep duration had low testosterone (odds ratio = 2.03; 95% confidence interval: 1.10, 3.73). A J‐shaped association between sleep duration and low testosterone (odds ratio≤6 h = 1.57; 95% confidence interval: 1.10, 2.27; odds ratio≥9 h = 2.06; 95% confidence interval: 1.18, 3.59) was observed in women aged 41–64 years. We did not find any association with sleep quality.ConclusionThe association of sleep duration with serum testosterone concentrations varies with sex and age group. Prospective studies are warranted to confirm these sex and age group differences.

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Section: Discussionmentioning

confidence: 87%

Section: Ta B L Ementioning

confidence: 99%

Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

et al. 2023

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Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study

Sharma,

Cook,

Antonio

et al. 2023

BMC Geriatr

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Background Previous studies have suggested an association between sleep disturbance and frailty. The mechanism is unknown, although it has been suggested that hormonal factors may play a role. Methods The aim was to determine the association between sleep duration, sleep quality and frailty, and to determine whether testosterone influenced this association. Males aged 40–79 years were recruited from eight European centres to the European Male Aging Study (EMAS). Subjects completed an interviewer-assisted questionnaire including questions regarding sleep quality and duration. Sleep quality was scored 0–20 and categorised as 0–4, 5–9, 10–14, and 15–20, with higher scores indicating poorer quality. A 39-component frailty index (FI) was constructed. Total testosterone levels were measured. The association between sleep duration, sleep quality and the FI was assessed using negative binomial regression, with adjustment for putative confounders including testosterone level. Results Two thousand three hundred ninety-three participants contributed data to the analysis. The mean age was 63.3 years and mean sleep duration was 7.01 h. The mean frailty index was 0.15. Mean testosterone levels declined with decreasing sleep quality. After adjustment, compared to those with a sleep score of 0–4, the FI was 57% (95% CI 38%, 78%) higher among those with a sleep score of 15–20. After adjustment compared to those with normal sleep duration (6–9 h), those with a short (< 6 h) and long (≥ 9 h) sleep duration had a 16% (95% CI 6%, 28%) and 11% (95% CI 0%, 23%) higher FI, respectively. Adjustment for testosterone did not influence the strength of either association. Conclusion Frailty is associated with impaired sleep quality and sleep duration. The association cannot, however, be explained by variation in testosterone levels.

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Associations of testosterone and cortisol concentrations with sleep quality in Japanese male workers

Cited by 2 publications

References 46 publications

Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study

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