Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression

Shell, Aubrey L.; Williams, Michelle; Patel, Jay S.; Vrany, Elizabeth A.; Considine, Robert V.; Acton, Anthony J.; Stewart, Jesse C.

doi:10.1007/s10865-022-00356-9

Cited by 5 publications

(4 citation statements)

References 73 publications

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“…As far as we know, no study has ever examined this before among BD population. However, in patients with depression from western countries, hypersomnia and hyperphagia were found to be positively associated with HOMA-IR or level of insulin [ 43 , 44 ]. BMI, C-reactive protein, and race were reported to mediated the association between hyperphagia or hypersomnia and insulin resistance [ 43 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, in patients with depression from western countries, hypersomnia and hyperphagia were found to be positively associated with HOMA-IR or level of insulin [ 43 , 44 ]. BMI, C-reactive protein, and race were reported to mediated the association between hyperphagia or hypersomnia and insulin resistance [ 43 , 45 ]. Therefore, it is speculated that difference in ethnicity and BMI might contribute to the different association between atypical features of depressive episode and IR.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of insulin resistance and its associated factors in drug-naïve patients with bipolar disorder among Han Chinese population

Li,

Yang

et al. 2024

BMC Psychiatry

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Background Metabolic syndrome (Mets) is commonly seen in bipolar disorder (BD). As the key component and early biological index of Mets, insulin resistance (IR) among BD has received more and more attention. However, little is known about the prevalence of IR and its associated factors in drug-naïve patients with (BD), especially among Han Chinese population. Methods A cross-sectional study was conducted on 125 drug-naïve patients with bipolar disorder (BD) and 85 healthy controls (HC). The Homeostatic Model Assessment of insulin resistance (HOMA-IR) was calculated, and IR was defined as HOMA-IR greater than the 75th percentile value for health controls (2.35). Clinical characteristics of BD were collected through semi-structural interview performed by a trained interviewer with background of psychiatric education. Results Among the measured anthropocentric variables including BMI, waist circumference, abdomen circumference, hipline, and hip-waist ratio, waist circumference was found to be the most closely related to IR (0R = 1.070, 95%CI = 1.031–1.110, P < 0.001). Male was another factor that was associated with IR (OR = 2.281, 95%CI = 1.107–4.702, P = 0.025). After adjusted for gender and waist circumference, the risk of IR was significantly higher in bipolar disorder than in healthy controls (OR = 2.66, 95%CI = 1.364–5.214, P = 0.004). No significant association was found between IR and any of the observed physical and mental comorbidities, any characteristic of illness course including age onset, number of mixed episodes, types of current state, duration of current episode, duration of illness course, rapid cycling, number of mood episodes, and subgroup of BD. Hypersomnia was the only symptomatic feature that was significantly associated with IR (OR = 0.316, 95%CI = 0.124–0.803, P = 0.016). Conclusions Bipolar disorder increases two-to-three-fold risk of IR, both circumference and male are the risk factors of IR but hypersomnia act as a protective factor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of insulin resistance and its associated factors in drug-naïve patients with bipolar disorder among Han Chinese population

Li,

Yang

et al. 2024

BMC Psychiatry

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“…In line with the findings of the Netherlands Study of Depression and Anxiety [12 ▪▪ ], their work reinforced the links between metabolic markers and atypical presentation of MDD and the observation, that those relationships are mainly noted for insomnia rather than hypersomnia. Similarly, in a cross-sectional analysis of primary care population Shell et al [13 ▪ ] detected significant links between IR and increased food intake, hypersomnia (positive) and reduced food intake (negative). The relationship between IR and overeating was only significant for White participants but not for Black participants.…”

Section: Metabolic Subtype Of Depressionmentioning

confidence: 99%

Consolidating evidence on the role of insulin resistance in major depressive disorder

Krupa,

Dudek,

Siwek

2023

Current Opinion in Psychiatry

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Purpose of review The circular interactions between type 2 diabetes (TMD2) and major depressive disorder (MDD) are well documented but the understanding of their mechanisms has only recently gained more clarity. Latest research indicates, that the association between TMD2 and MDD is largely mediated by insulin resistance (IR). Recent findings A metabolic subtype of MDD can be distinguished from other MDD subpopulations, that is characterized by predominantly atypical clinical presentation, IR and different responsiveness to antidepressant interventions. IR is a predictor of nonresponse to some antidepressants. The IR seems to be a state-marker of clinical or subclinical depression and the relationship between IR and MDD varies between sexes and ethnicities. Insulin has a direct impact on the monoaminergic systems known to underlie MDD symptoms: serotoninergic and dopaminergic, which are dysregulated in IR subjects. Several trials assessed the efficacy of insulin-sensitizing drugs in MDD with mixed results for metformin and more consistent evidence for pioglitazone and lifestyle intervention/physical activity. Summary Recently published data suggest a significant role of IR in the clinical presentation, pathophysiology and treatment response in MDD. Further research of IR in MDD and integration of existing data into clinical practice are needed.

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“…All of these factors contribute to atherosclerosis and worsening PAD. [76][77][78] These 2 considerations further highlight the importance of addressing mental health from a personcentered, humanistic, and ethical perspective, as well as from a biological and pathophysiological perspective.…”

Section: Mental Health and Pad Treatment Considerationsmentioning

confidence: 99%

Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association

Smolderen,

Samaan,

Decker

et al. 2023

Circulation

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Along with the rising burden of peripheral artery disease (PAD), mental health concerns are increasingly being recognized as a comorbidity to address in the chronic disease management of symptomatic PAD. Apart from a high prevalence of comorbid mental health conditions, the role of pain and changing health behaviors and the broader impacts of illness and adaptation to living with PAD require specialized behavioral health expertise. This scientific statement builds a case that this expertise should be integrated within the multidisciplinary PAD team. Furthermore, areas such as cognitive dysfunction and palliative care are highlighted as needing psychological interventions. Although much of the evidence of the efficacy of psychological and psychotropic interventions has been extrapolated from other cardiovascular populations, evidence for the role of psychological interventions for behavior change, for example, uptake of exercise regimens, is increasingly being accrued within PAD. Areas for behavioral health needs and interactions with PAD treatment are discussed, including the use of opioids, depression management, anxiety and stress reduction interventions, the use of benzodiazepines and antidepressants, smoking cessation, rehabilitation trajectories after amputation, and the role of cognitive decline for PAD treatment and outcomes. A case summary highlights the stigma around mental health and vascular disease and the fragmentation of care. This scientific statement provides remarks for building a road map for integrated behavioral PAD care and potential solutions to overcome these barriers. Instrumental to reaching these changes are interprofessional advocacy efforts and initiatives that help break down the stigma around mental health and promote evidence-based collaborative, nonhierarchical, and multidisciplinary PAD care.

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Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression

Cited by 5 publications

References 73 publications

Prevalence of insulin resistance and its associated factors in drug-naïve patients with bipolar disorder among Han Chinese population

Prevalence of insulin resistance and its associated factors in drug-naïve patients with bipolar disorder among Han Chinese population

Consolidating evidence on the role of insulin resistance in major depressive disorder

Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association

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