Associations of snoring frequency and intensity in pregnancy with time‐to‐delivery

Abstract

Background Sleep disordered-breathing (SDB) is linked to adverse pregnancy outcomes. However, little is known about the association of SDB with timing of delivery. We examined the association of snoring frequency, a key SDB marker, and snoring intensity, a correlate of SDB severity, with time-to-delivery among a cohort of pregnant women. Methods In this prospective cohort study, 1,483 third trimester pregnant women were recruited from the University of Michigan prenatal clinics. Women completed a questionnaire about their sleep, and demographic and pregnancy information was abstracted from medical charts. After exclusion of those with hypertension or diabetes, 954 women were classified into two groups by their snoring-onset timing, chronic or pregnancy-onset. Within each of these groups, women were divided into four groups based on their snoring frequency and intensity: non-snorers, infrequent-quiet, frequent-quiet, or frequent-loud snorers. Cox proportional hazard regression models were used to investigate the association between snoring frequency and intensity and time-to-delivery, adjusting for maternal characteristics. Results Chronic snoring was reported by half of the pregnant women, and of those, 7% were frequent-loud snorers. Deliveries before 38 weeks’ gestation are completed occurred among 25% of women with chronic, frequent-loud snoring. Compared with pre-pregnancy non-snorers, women with chronic frequent-loud snoring had an increased hazard-ratio for delivery; [adjusted HR=1.60, (95% CI 1.04, 2.45)]. Conclusions Snoring frequency and intensity is associated with time-to-delivery in women absent of hypertension or diabetes. Frequent-loud snoring may have a clinical utility to identify otherwise low-risk women who are likely to deliver earlier.

Eyes-Open and Eyes-Closed Resting States With Opposite Brain Activity in Sensorimotor and Occipital Regions: Multidimensional Evidences From Machine Learning Perspective

“…The linear trend, Friston 24-parameter and signals from WM and CSF were removed as nuisance variables to reduce head motion, respiratory and cardiac effects. Global signal regression was not performed because of concerns about increasing negative correlations (Murphy et al, 2009 ; Weissenbacher et al, 2009 ) and possible distortions (Gotts et al, 2013 ; Chi et al, 2016 ; Liu et al, 2017 ). After nuisance regression, the functional volumes were then normalized to MNI152 space in 3 × 3 × 3 mm 3 voxel resolution by using the transformation information acquired from the previous DARTEL step (Figure 2 ).…”

Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy

“…It is likely their SDB preceded pregnancy and they were not aware of it, or not sufficiently concerned to seek medical investigation. It remains unclear whether pre-existing SDB or the development of SDB in pregnancy is more problematic for pregnancy outcomes, [55][56][57] however this exclusion criteria was unlikely to impact our results.…”

Associations between symptoms of sleep-disordered breathing and maternal sleep patterns with late stillbirth: Findings from an individual participant data meta-analysis

“…The cardinal symptom, habitual snoring �3 nights per week, affects up to 35% of women in the third trimester [4,5], and up to 85% of women with pre-eclampsia [6], while objective measures of OSA are estimated to affect between 8% and 26% of pregnant women [7,8]. SDB is a risk factor for adverse pregnancy outcomes, including gestational hypertension and pre-eclampsia [4,9,10], hyperglycaemia [11][12][13], impaired fetal growth [14][15][16][17][18][19], and early-term and/or preterm birth [9,14,[20][21][22]. SDB is exacerbated by obesity, advanced gestation, and the supine sleep position [23], all of which are themselves associated with an increased risk of late stillbirth [24].…”