Associations of Sleep-disordered Breathing and Insomnia with Incident Hypertension and Diabetes. The Hispanic Community Health Study/Study of Latinos

Li, Xiaoyü; Sotres-Álvarez, Daniela; Gallo, Linda C.; Ramos, Alberto R.; Avilés-Santa, Larissa; Perreira, Krista M.; Isasi, Carmen R.; Zee, Phyllis C.; Savin, Kimberly L.; Schneiderman, Neil; Wassertheil‐Smoller, Sylvia; Sofer, Tamar; Daviglus, Martha L.; Redline, Susan

doi:10.1164/rccm.201912-2330oc

Cited by 52 publications

(32 citation statements)

References 73 publications

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“…In this context, we eagerly read the recent paper by Li and colleagues (10), which prospectively confirmed the associations between SDB and insomnia with incident hypertension (HT) and diabetes (DM) in US Hispanic/Latino subjects. Since this particular sector of the US population has been recognized as carrying a higher risk of sleep disorders and of cardiometabolic disorders, the assumption that sleep perturbations are a modifiable target for disease prevention or risk reduction is particularly attractive and clinically relevant.…”

Section: To the Editormentioning

confidence: 91%

A Reappraisal on the Associations between Sleep-disordered Breathing, Insomnia, and Cardiometabolic Risk

Cruz

Salles

Gozal

2021

Am J Respir Crit Care Med

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Section: To the Editormentioning

confidence: 91%

A Reappraisal on the Associations between Sleep-disordered Breathing, Insomnia, and Cardiometabolic Risk

Cruz

Salles

Gozal

2021

Am J Respir Crit Care Med

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“…Snoring is associated with obstructive sleep apnea and the rates of sleep disordered breathing among individuals of Mexican descent is substantial. In a recent study by Li and colleagues [83], sleep disordered breathing was associated with 54% increased likelihood of hypertension and 33% increased likelihood of diabetes among the U.S. Hispanic/Latino population [24,83]. This has important implications as sleep disorders are underrepresented, underreported, and undertreated among Hispanic/Latino populations.…”

Section: Resultsmentioning

confidence: 99%

Culturally-consistent diet among individuals of Mexican descent at the US-Mexico border is associated with sleep duration and snoring

et al. 2021

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Background Existing studies show that consuming food consistent with one’s culture reduces cardiometabolic risk. However, few studies have assessed whether these dietary choices influence sleep health. Accordingly, this study assessed how Mexican food consumption by individuals of Mexican descent residing at the US-Mexico border, was associated with various measures of sleep, after accounting for acculturation. Methods Data were provided by 100 adults between the ages of 18–60, in the city of Nogales, AZ. Questionnaires were provided in either Spanish or English. Acculturation was assessed with the Acculturation Scale for Mexican-Americans (ARSMA-II), with an additional question, asking how often “my family cooks Mexican foods.” Frequency of cooking Mexican food was coded as either “yes” or “no.” Sleep was assessed, using validated measures that include the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI), and sleep duration with the item “how many hours of actual sleep did you get at night?” Regression models estimated the associations between sleep health variables as outcomes and consumption of Mexican food as the independent variable. Covariates included age, sex, and acculturation scores. Parental education level was also included, as an indicator of childhood socioeconomic status and since food culture likely involves parents. Result We found that among individuals who identified as Mexican-Americans who consumed culturally-consistent foods, was associated with, on average, 1.41 more hours of sleep (95% CI 0.19, 2.62; p = 0.024) and were less likely to report snoring (OR: 0.25; 95% CI 0.07, 0.93; p = 0.039). Consuming Mexican food was not associated with sleep quality, insomnia severity or sleepiness. Conclusion Individuals of Mexican descent residing at the US-Mexico border who regularly consumed Mexican food, reported more sleep and less snoring. Mexican acculturation has been shown previously to improve sleep health. This is likely due to consumption of a culturally- consistent diet. Future studies should examine the role of acculturation in sleep health, dietary choices, and subsequent cardiometabolic risk.

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“…Six such studies with follow-up periods between 2.7 and 12.8 years showed the presence of a significant association between OSA and incident T2DM after adjustment for the usual confounders ( Botros et al, 2009 ; Marshall et al, 2009 ; Boyko et al, 2013 ; Kendzerska et al, 2014 ; Appleton et al, 2016 ; Nagayoshi et al, 2016 ). The prospective association of sleep-disordered breathing with incident diabetes among United States Hispanic/Latino people over 6 years of follow-up has recently been published ( Li et al, 2021 ). In this study, mild or moderate-to-severe OSA was associated with 1.33 odds of incident diabetes (95% CI 1.05–1.67) compared with no OSA.…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up

et al. 2021

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The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort study (n = 1,011). After 7 years follow-up, 494 subjects underwent assessment of fasting insulin and glucose levels. OSA was defined by an apnea-hypopnea index (AHI) of ≥15/h using polygraphy. Diabetes mellitus was defined by a fasting glucose ≥ 1.26 g/L and/or when requiring pharmacological treatment, while insulin resistance corresponded to HOMA-IR ≥ 2. Asymptomatic OSA subjects (men or women) did not display increased risk of incident diabetes (2.8 vs. 3.9%, p = 0.51). However, there was a greater frequency of insulin resistance in subjects with severe OSA (AHI > 30) [OR 2.21; 95% CI (1.22–4.02); p = 0.009]. Furthermore, multiple logistic regression showed that triglycerides levels [OR 1.61; 95% CI (1.10–2.36); p = 0.01] and fasting glycaemia [OR 4.69; 95% CI (1.12–192.78); p = 0.04], but not AHI or oxyhemoglobin desaturation index were independently associated with higher rate of insulin resistance. The deleterious metabolic effect of asymptomatic OSA in the population may be indirectly mediated via perturbations in lipids, and is particularly likely to become manifest in severe apneic subjects with higher glycemic levels.

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Associations of Sleep-disordered Breathing and Insomnia with Incident Hypertension and Diabetes. The Hispanic Community Health Study/Study of Latinos

Cited by 52 publications

References 73 publications

A Reappraisal on the Associations between Sleep-disordered Breathing, Insomnia, and Cardiometabolic Risk

A Reappraisal on the Associations between Sleep-disordered Breathing, Insomnia, and Cardiometabolic Risk

Culturally-consistent diet among individuals of Mexican descent at the US-Mexico border is associated with sleep duration and snoring

Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up

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