Associations of serum vitamin C concentrations with risk of all-cause and cause-specific mortality among individuals with and without type 2 diabetes

Ou, Yunjing; Qiu, Zixin; Geng, Tingting; Lu, Qi; Li, Rui; Lei, Lin; Zhu, Kaiheng; Chen, Xue; Lin, Xiaoyu; Liu, Sen; Pan, An; Liu, Gang

doi:10.1007/s00394-023-03173-1

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Thus, the enhanced requirements for vitamin C in the group with diabetes likely comprises a combination of higher body weight and enhanced renal dysfunction, with a likely contribution by elevated oxidative stress. Since higher dietary intakes and circulating concentrations of vitamin C have been associated with a lower risk of diabetes morbidity and mortality [6,7], increasing vitamin C intake in people with diabetes to account for their higher requirements may help attenuate the progression of the disease to more severe complications. In support of this premise, meta-analyses of intervention studies have indicated that supplementation with vitamin C can improve dysregulated glycaemic and lipid markers and cardiovascular risk factors in people with diabetes [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

“…Although best known for its antioxidant activities, being able to scavenge a wide range of reactive oxygen species, the vitamin has pleiotropic functions in human physiology through Antioxidants 2023, 12, 1863 2 of 14 acting as a cofactor for a family of metalloenzymes that have numerous biosynthetic and regulatory functions [2][3][4]. As such, there has been significant interest in the role of vitamin C in both the prevention and treatment of various conditions, particularly those potentially modifiable by lifestyle and dietary changes, such as type 2 diabetes mellitus (T2DM) [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017–2018 and EPIC-Norfolk Cohorts

Carr,

Lunt,

Wareham

et al. 2023

Antioxidants

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Vitamin C is an essential enzyme cofactor and antioxidant with pleiotropic roles in human physiology. Circulating vitamin C concentrations are lower in people with diabetes mellitus, suggesting a higher dietary requirement for the vitamin. We interrogated the NHANES 2017–2018 and EPIC-Norfolk datasets to compare vitamin C requirements between those with and without diabetes mellitus using dose–concentration relationships fitted with sigmoidal (four-parameter logistic) curves. The NHANES cohort (n = 2828 non-supplementing adults) comprised 488 (17%) participants with diabetes (self-reported or HbA1c ≥ 6.5%). The participants with diabetes had a lower vitamin C status (median [IQR]) than those without (38 [17, 52] µmol/L vs. 44 [25, 61] µmol/L, p < 0.0001), despite comparable dietary intakes between the two groups (51 [26, 93] mg/d vs. 53 [24, 104] mg/d, p = 0.5). Dose–concentration relationships indicated that the group without diabetes reached adequate vitamin C concentrations (50 µmol/L) with an intake of 81 (72, 93) mg/d, whilst those with diabetes required an intake of 166 (126, NA) mg/d. In the EPIC-Norfolk cohort, comprising 20692 non-supplementing adults, 475 (2.3%) had self-reported diabetes at baseline. The EPIC cohort had a lower BMI than the NHANES cohort (26 [24, 28] kg/m2 vs. 29 [25, 34] kg/m2, p < 0.0001). Correspondingly, the EPIC participants without diabetes required a lower vitamin C intake of 64 (63, 65) mg/d while those with diabetes required 129 (104, NA) mg/d to reach adequate circulating vitamin C status. C-reactive protein concentrations were strongly correlated with body weight and BMI and provided a surrogate biomarker for vitamin C requirements. In conclusion, people with diabetes had 1.4 to 1.6 fold higher requirements for vitamin C than those without diabetes. This corresponds to additional daily vitamin C intake requirements of ~30–40 mg for people with diabetes, equating to a total daily intake of at least 125 mg/d.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017–2018 and EPIC-Norfolk Cohorts

Carr,

Lunt,

Wareham

et al. 2023

Antioxidants

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Association between cardiometabolic index and depression: National Health and Nutrition Examination Survey (NHANES) 2011–2014

Zhou,

Tao,

Zhang

et al. 2024

Journal of Affective Disorders

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Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020

Tang,

Xu,

Wang

et al. 2023

BMC Public Health

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Background Obesity has been confirmed to be associated with infertility. However, the association between metabolically healthy obesity (MHO), a subset of obesity with no metabolic abnormalities, and female infertility has not yet been investigated. This study aimed to examine the association between MHO and the risk of female infertility among United States. Methods This study utilized a cross-sectional design and included 3542 women aged 20–45 years who were selected from the National Health and Nutrition Examination Survey (NHANES) 2013–2020 database. The association between MHO and the risk of infertility was evaluated using risk factor–adjusted logistic regression models. Results Higher BMI and WC were associated with increased infertility risk after adjusting for potential confounding factors (OR (95% CI): 1.04(1.02, 1.06), P = 0.001; OR (95% CI): 1.02 (1.01, 1.03), P < 0.001; respectively). After cross-classifying by metabolic health and obesity according to BMI and WC categories, individuals with MHO had a higher risk of infertility than those with MHN (OR (95% CI): 1.75(0.88, 3.50) for BMI criteria; OR (95% CI): 2.01(1.03, 3.95) for WC criteria). A positive linear relationship was observed between BMI/WC and infertility risk among metabolically healthy women (Pnon−linearity=0.306, 0.170; respectively). Conclusions MHO was associated with an increased risk of infertility among reproductive-aged women in the US. Obesity itself, regardless of metabolic health status, was associated with a higher infertility risk. Our results support implementing lifestyle changes aimed at achieving and maintaining a healthy body weight in all individuals, even those who are metabolically healthy.

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Associations of serum vitamin C concentrations with risk of all-cause and cause-specific mortality among individuals with and without type 2 diabetes

Cited by 3 publications

References 38 publications

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017–2018 and EPIC-Norfolk Cohorts

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017–2018 and EPIC-Norfolk Cohorts

Association between cardiometabolic index and depression: National Health and Nutrition Examination Survey (NHANES) 2011–2014

Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020

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