Associations of Serum Leptin with Atopic Asthma and Allergic Rhinitis in Children

Quek, Yeak-Wun; Sun, Hai-Lun; Ng, Yan-Yan; Lee, Hong-Shen; Yang, Shun‐Fa; Ku, Min‐Sho; Lu, Ko-Hsiu; Sheu, Ji-Nan; Lue, Ko-Huang

doi:10.2500/ajra.2010.24.3483

Cited by 27 publications

(27 citation statements)

References 33 publications

(60 reference statements)

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“…Recent studies have suggested that the influence of leptin on increasing risk of asthma varied by sex. 33,35,38,39 In the present study, it was found that independent of having asthma, leptin levels of girls were higher than in boys in all groups except obese asthmatics. However, a similar sex difference concerning adiponectin levels was not evident.…”

Section: Discussionmentioning

confidence: 48%

“…This finding suggests that increased leptin levels in girls are related to sex, regardless of asthma. Some other studies have also revealed that higher serum leptin levels are strongly associated with female sex in asthmatic children 17,30,38,39 and adults. 36 In contrast, another study found higher serum leptin levels in asthmatic prepubertal boys, particularly in atopics.…”

Section: Discussionmentioning

confidence: 91%

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Evaluation of Serum Leptin and Adiponectin Levels in Obese and Lean Asthmatic Children

Köksal

OzbekOzlem

Bayraktar

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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Background: Adipokines have been claimed for the link between obesity and asthma. The aim of the present study was to evaluate the roles of leptin and adiponectin in children with asthma and/or obesity and their effect on pulmonary functions. Methods: Obese (n = 71) and lean asthmatics (n = 72), obese non-asthmatics (n = 46), and lean healthy children (n = 49) were included in the study. Serum leptin and adiponectin levels were compared according to groups and sex. Results: Mean leptin levels of obese asthmatics were higher than those of lean asthmatics (13.1 -9.1 vs. 3.7 -4.4; p < 0.001). Serum adiponectin levels of lean asthmatics (16 -7.1) were significantly higher than those of obese asthmatics (12.1 -6.9; p < 0.001) and of their lean healthy (13.2 -5.9; p < 0.05) counterparts. In obese asthmatics, adiponectin levels were positively correlated with the forced expiratory volume in one second (FEV 1 )/forced vital capacity (FVC) ratio, and serum leptin levels were inversely correlated with forced expiratory flow ). Leptin/adiponectin ratio was inversely correlated with FEV 1 /FVC ratio in lean and obese asthmatic patients. Conclusions: The present findings suggest that adiponectin may have protective disease modifying effect(s) in asthmatic children. Anti-inflammatory mechanisms regarding adiponectin may work better in girls than in boys.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 91%

Evaluation of Serum Leptin and Adiponectin Levels in Obese and Lean Asthmatic Children

Köksal

OzbekOzlem

Bayraktar

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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“…The influence of leptin on increasing asthma risks varied by gender has been reported [31]. Among asthmatic children, higher serum leptin levels were shown to have stronger associations with female gender [32]. On the other hand, in a case control study conducted in 102 prepubertal asthmatic children, significant difference was observed in serum leptin levels between asthmatic and healthy children.…”

Section: Discussionmentioning

confidence: 99%

Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control

et al. 2013

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There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese asthmatic (NOA) children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and analyzed. Serum leptin was significantly higher (25.8 ± 11.1 versus 8.7 ± 11.1; P < 0.0001) and adiponectin levels were lower (2.5 ± 1.2 versus 5.4 ± 2.9; P < 0.0001) in OA compared to NOA children. The uncontrolled group had higher leptin and lower adiponectin levels compared to well and partially controlled asthma. BMI was positively correlated with leptin (r = 0.79; P < 0.001) and negatively with adiponectin (r = −0.73; P < 0.001). Mean BMI and leptin levels were observed to be higher in girls compared to boys. Stepwise multiple linear regression analysis showed that higher BMI and female gender had significant effect on serum leptin levels. Among asthmatic children higher serum leptin and lower adiponectin levels were significantly associated with obesity and showed no significant association with degree of asthma controls.

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“…The Taiwanese study followed adolescents prospectively for 12 months, and reported that obese adolescent females but not males were at higher risk of developing asthma [24]. Interestingly, higher serum leptin levels were associated with obesity, female gender and asthma [25•]. Leptin, which plays a key role in body weight regulation, promotes Th1 immune responses and increases the production of pro-inflammatory mediators [25•].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, higher serum leptin levels were associated with obesity, female gender and asthma [25•]. Leptin, which plays a key role in body weight regulation, promotes Th1 immune responses and increases the production of pro-inflammatory mediators [25•]. The gender dimorphism of the obese-asthma phenotype is supported by the finding that asthma impairment related to obesity is highest among women 12 to 44 years of age [26, 27].…”

Section: Introductionmentioning

confidence: 99%

Asthma is Different in Women

Zein

Erzurum

2015

Curr Allergy Asthma Rep

247

179

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Gender differences in asthma incidence, prevalence and severity have been reported worldwide. After puberty, asthma becomes more prevalent and severe in women, and is highest in women with early menarche or with multiple gestations, suggesting a role for sex hormones in asthma genesis. However, the impact of sex hormones on the pathophysiology of asthma is confounded by and difficult to differentiate from age, obesity, atopy, and other gender associated environmental exposures. There are also gender discrepancies in the perception of asthma symptoms. Understanding gender differences in asthma is important to provide effective education and personalized management plans for asthmatics across the lifecourse.

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Associations of Serum Leptin with Atopic Asthma and Allergic Rhinitis in Children

Cited by 27 publications

References 33 publications

Evaluation of Serum Leptin and Adiponectin Levels in Obese and Lean Asthmatic Children

Evaluation of Serum Leptin and Adiponectin Levels in Obese and Lean Asthmatic Children

Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control

Asthma is Different in Women

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