Associations of serologic markers of infection and inflammation with vascular disease events and mortality in American dialysis patients

Lentine, Krista L.; Parsonnet, Julie; Taylor, Isabella; Wrone, Elizabeth M.; Lafayette, Richard A.

doi:10.1007/s10157-005-0392-5

Cited by 13 publications

(13 citation statements)

References 30 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the carotid artery intima-media thickness has been reported to be greater in patients with IgA antibodies compared with patients without antibodies (27), and the number of atherosclerotic plaques is related to the titer of IgG antibodies in smokers but there is no such relationship in nonsmokers (28). In contrast, other authors found no differences in atherosclerosis scores between patients with and without antibodies (29), and the association with atherosclerotic disease was found to be very weak (30). Therefore, the relationship between infection with C. pneumoniae and atherosclerosis has not been established clearly.…”

Section: Infectionsmentioning

confidence: 87%

“…Therefore, the relationship between infection with C. pneumoniae and atherosclerosis has not been established clearly. There is no clear connection between inflammation and H. pylori infection in HD patients either, as recently demonstrated (30). Consequently, further studies to establish the possible relationship between these infections and atherosclerosis are needed.…”

Section: Infectionsmentioning

confidence: 97%

See 1 more Smart Citation

Inflammatory Syndrome in Patients on Hemodialysis

Jofre

Rodríguez-Benítez²,

López‐Gómez³

et al. 2006

Journal of the American Society of Nephrology

202

169

View full text Add to dashboard Cite

Mortality is markedly elevated in hemodialysis (HD) patients. Between 30 and 50% of prevalent patients have elevated serum levels of inflammatory markers such as C-reactive protein and IL-6. The presence of inflammation, chronic or episodic, has been found to be associated with increased mortality risk. The causes of inflammation are multifactorial and include patient-related factors, such as underlying disease, comorbidity, oxidative stress, infections, obesity, and genetic or immunologic factors, or on the other side, HD-related factors, mainly depending on the membrane biocompatibility and dialysate quality. The adequate knowledge of these causes and their prevention or treatment if possible may contribute to improving the inflammatory state of patients who are on HD and possibly their mortality.

show abstract

Section: Infectionsmentioning

confidence: 87%

Section: Infectionsmentioning

confidence: 97%

Inflammatory Syndrome in Patients on Hemodialysis

Jofre

Rodríguez-Benítez²,

López‐Gómez³

et al. 2006

Journal of the American Society of Nephrology

202

169

View full text Add to dashboard Cite

show abstract

“…The gastric mucosa of approximately 50% of the world's population is infected with H. pylori, and the infection levels exceed 70% in some developing areas (14,15). Helicobacter pylori infection plays a crucial role in the development of gastrointestinal diseases, such as peptic ulcer, gastric hyperplastic polyps, gastric adenoma, gastric cancer, and gastric mucosa associated-lymphoid tissue lymphoma, both in individuals with normal renal function and in chronic renal failure patients receiving hemodialysis and CAPD (Tables 1 and 2) (4-9, 16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]34,[36][37][38][39][40][41][42][43][44][45][47][48][49][50][51][52][53][54][55][56][57][58][59][60].…”

mentioning

confidence: 99%

Review of Helicobacter pylori Infection and Chronic Renal Failure

Sugimoto

Yamaoka

2010

Ther Apher Dial

View full text Add to dashboard Cite

Chronic renal failure patients receiving hemodialysis and continuous ambulatory peritoneal dialysis often encounter gastrointestinal troubles over their long treatment period. Helicobacter pylori infection has close association with development of peptic ulcer, gastric cancer and gastric lymphoma, and is thought to be one of the major risk factors for gastrointestinal troubles in dialysis patients. However, it is unclear whether H. pylori infection is directly associated with progression of renal dysfunction and prognosis of chronic renal failure patients. Recent consensus shows that the prevalence of H. pylori infection in chronic renal failure patients is significantly lower than in subjects with normal renal function. In the natural history of H. pylori infection in hemodialysis patients, the prevalence of infection decreases as dialysis periods progressed, in particular within the first four years after the start of treatment. However, the chance of natural eradication becomes rare for patients receiving dialysis treatment for a long time. Moreover, chronic renal failure patients with H. pylori infection have a higher incidence of gastroduodenal diseases, and therefore, are recommended to receive eradication therapies, especially for those receiving treatment for a long time and with higher risks of complication. Intensive endoscopic check-ups for the prevention of gastrointestinal events and the discovery of peptic ulcer and neoplastic diseases at an early phase may be required.

show abstract

“…In particular, both anti-CP IgG and IgA antibodies titers have been associated to progression of carotid atherosclerosis and ischemic heart disease (Kato et al 2004;Wszola et al 2006). However, in the clinical setting, together with a great deal of studies reporting the close association between CP infection and CVD, both in general and HD population (Lentine et al 2006), conflicting evidence by observational and interventional studies also exists (Ieven and Hoymans 2005;O'Connor et al 2003). Some authors have proposed CP infection only having a subsidiary role in atherosclerosis development in HD patients (Kato et al 2006).…”

Section: Discussionmentioning

confidence: 95%

Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients

Esposito

Tinelli

Libetta

et al. 2011

Cell Stress and Chaperones

View full text Add to dashboard Cite

Autoimmunity to heat shock protein 60 (HSP60) has been related to atherosclerosis. Chlamydia pneumoniae (CP), the most studied infectious agent implicated in promoting atherosclerosis, produces a form of HSP60, which can induce an autoimmune response, due to high antigenic homology with human HSP60 (hHSP60). In this study, we evaluated the correlations among anti-hHSP60 antibodies, CP infection, and cardiovascular disease (CVD) in a high-risk population, such as patients undergoing hemodialysis (HD). Thirty-two patients (67.9±13.9 years; male/female, 23:9) on regular HD were enrolled. Global absolute cardiovascular risk (GCR) was assessed using the Italian CUORE Project's risk charts, which evaluate age, gender, smoking habits, diabetes, systolic blood pressure, and serum cholesterol. The occurrence of cardiovascular events during a 24-month follow-up was recorded. Seropositivity to CP and the presence of anti-hHSP60 antibodies were tested by specific enzyme-linked immunosorbent assays. Inflammation was assessed by measurement of Creactive protein (CRP) serum levels. Fifteen healthy sex and age-matched (61.9± 9.5 years; male/female, 11:4) subjects were the control group. Fifteen of 32 patients resulted seropositive for CP. CP+patients were older than CP−, while they did not differ for GCR, CRP, and dialytic parameters. CVD incidence was significantly higher in CP+ (9 CP+ vs 2 CP−, p<0.05). Cox analysis recognized that the incidence of CVD was independently correlated with seropositivity to CP (HR, 7.59; p=0.01;). On the other hand, there were no significant differences in anti-hHSP60 levels among CP+, CP− and healthy subjects: 18.11 μg/mL (14.8-47.8), 31.4 μg/mL (23.2-75.3), and 24.72 μg/mL (17.7-41.1), respectively. Anti-hHSP60 did not correlate to GCR, CRP, and incidence of CVD. In conclusion, our data suggest that anti-hHSP60 autoimmune response is not related to CP infection and CPrelated CVD risk in HD patients.

show abstract

Associations of serologic markers of infection and inflammation with vascular disease events and mortality in American dialysis patients

Cited by 13 publications

References 30 publications

Inflammatory Syndrome in Patients on Hemodialysis

Inflammatory Syndrome in Patients on Hemodialysis

Review of Helicobacter pylori Infection and Chronic Renal Failure

Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients

Contact Info

Product

Resources

About